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Cancer ; 62(11): 2297-300, 1988 Dec 01.
Article in English | MEDLINE | ID: mdl-3179945

ABSTRACT

Porphobilinogen deaminase (PBGD), one of the enzymes in the pathway of heme synthesis, was found to be elevated in peripheral mononuclear cells of 60% of patients with epithelial tumors and metastatic spread, but only in 14% of patients with tumor and no evidence of metastases. The combination of both high lactic dehydrogenase and high PBGD afforded a sensitivity of 40%, but a specificity of 96% in diagnosing metastatic spread.


Subject(s)
Ammonia-Lyases/blood , Hydroxymethylbilane Synthase/blood , Leukocytes, Mononuclear/enzymology , Neoplasm Metastasis/enzymology , Adult , Aged , Breast Neoplasms/enzymology , Female , Gastrointestinal Neoplasms/enzymology , Humans , Lung Neoplasms/enzymology , Male , Middle Aged , Ovarian Neoplasms/enzymology
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