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1.
Heliyon ; 6(1): e03026, 2020 Jan.
Article in English | MEDLINE | ID: mdl-32021918

ABSTRACT

Plastic films for food wrapping, packing are widely used due to their special properties. These fossil fuel derived films are associated with long degradation time, toxicity and environmental pollution. Pineapple waste, sea weed can be very good renewable, alternative carbon sources to produce edible films. These edible films can be consumed by lower animals thereby overcoming the disposal problems of accumulating waste plastic and hence reducing pollution. In the present study, crosslinked polymers are prepared from pectin (P)/sodium alginate (SA) through crosslinking with bio-based acids such as citric acid (CA) and tartaric acid (TA). Pectin was extracted from waste pineapple shell and sodium alginate extracted from seaweed. The crosslinked films were characterized by using various analytical techniques such as FT-IR, thermogravimetry, and scanning electron microscopy (SEM). Mice feed study (testing of edibility), plant growth substrate and vermicomposting of these films was studied. Finally a suitable application of these newly prepared polymeric films has been evaluated as wrapping material on food products such as chocolate and Indian vegetable puff to enhance the shelf life of food.

2.
Bioorg Med Chem ; 21(1): 365-72, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-23177727

ABSTRACT

Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of organism. Abnormal production of this superoxide's (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis and carcinogenesis. Series of novel trisubstituted thiophenyl-1-thiazolyl-2-pyrazoline libraries are synthesized containing 2,5-dichloro thiophene, 5-chloro-2-(benzylthio) thiophene and 5-chlorothiophene-2-sulphonamide, from chalcones in PEG-400 as green solvent. Superoxide (XO) inhibitory and free radical scavenging activities were also figured out with molecular modeling analysis, bearing in mind their possible future for super oxide inhibitor (Gout) therapeutics, compound 3k shows interesting superoxide inhibitory and free radical scavenger activity with IC(50)=6.2 µM, in comparison with allopurinol.


Subject(s)
Free Radical Scavengers/chemistry , Free Radical Scavengers/pharmacology , Thiophenes/chemistry , Thiophenes/pharmacology , Xanthine Oxidase/antagonists & inhibitors , Animals , Biphenyl Compounds/antagonists & inhibitors , Biphenyl Compounds/metabolism , Free Radical Scavengers/chemical synthesis , Green Chemistry Technology , Molecular Docking Simulation , Picrates/antagonists & inhibitors , Picrates/metabolism , Polyethylene Glycols/chemistry , Rats , Rats, Wistar , Reactive Oxygen Species/antagonists & inhibitors , Reactive Oxygen Species/metabolism , Superoxides/antagonists & inhibitors , Superoxides/metabolism , Thiophenes/chemical synthesis , Xanthine Oxidase/metabolism
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