ABSTRACT
BACKGROUND/AIMS: This investigation aimed to elucidate the expression patterns of S100A4 and adhesion molecules in gastric carcinoma and to estimate their correlation with clinicopathologic parameters. METHODOLOGY: The expression of S100A4, E-cadherin, alpha- and beta-catenin was studied in 251 gastric carcinoma specimens through immunohistochemical staining. RESULTS: The positive expression of S100A4 was significantly associated with advanced gastric cancer, higher pTNM stage, and poorer survival rates, especially when present in nuclear staining. The reduced expression of adhesion molecules was significantly associated with diffuse type of gastric cancer. The reduced expression of beta-catenin was significantly associated with lymph node metastasis, especially in early gastric cancer. The coexpression status of S100A4-positive and reduced beta-catenin was significantly associated with larger tumor size, advanced tumor depth, and higher pTNM stage. CONCLUSIONS: S100A4 and adhesion molecule expression may be a useful prognostic marker for individual gastric cancer patients.
Subject(s)
Adenocarcinoma/chemistry , Cadherins/analysis , S100 Proteins/analysis , Stomach Neoplasms/chemistry , alpha Catenin/analysis , beta Catenin/analysis , Adenocarcinoma/pathology , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , S100 Calcium-Binding Protein A4 , Stomach Neoplasms/pathologyABSTRACT
We report here on the multiple genital tract neoplasms in a 41-yr-old Korean woman with Peutz-Jeghers Syndrome (PJS). The patient presented with lower abdominal pain. Her previous medical history was PJS and breast cancer. Pelvic ultrasound showed a multilocular cyst at the right adnexal region, diagnosed as bilateral ovarian mucinous borderline tumors. An ovarian sex cord tumor with annular tubules was incidentally diagnosed together with a minimal deviation adenocarcinoma of the uterine cervix and mucinous metaplasia of both the Fallopian tubal mucosa and the endometrium. Although the cases of multiple genital tract tumors with PJS has rarely been reported, the present case appears to be the first in Korea in which the PJS syndrome was complicated by multiple genital tract tumors and infiltrating carcinoma of the breast. The clinical significance of the multiple genital tract tumors and breast cancer associated with PJS is reviewed.
Subject(s)
Breast Neoplasms/pathology , Ovarian Neoplasms/pathology , Peutz-Jeghers Syndrome/pathology , Uterine Cervical Neoplasms/pathology , Adenocarcinoma/complications , Adenocarcinoma/pathology , Adult , Breast Neoplasms/complications , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/pathology , Endometrium/pathology , Fallopian Tubes/pathology , Female , Humans , Korea , Metaplasia , Ovarian Neoplasms/complications , Peutz-Jeghers Syndrome/complications , Sex Cord-Gonadal Stromal Tumors/complications , Sex Cord-Gonadal Stromal Tumors/pathology , Uterine Cervical Neoplasms/complicationsABSTRACT
Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was noted. The EBV was detected by EBV-encoded RNA 1 messenger RNA in situ hybridization and polymerase chain reaction for EBV-encoded nuclear antigen 1. On immunohistochemical staining, the infiltrated lymphoid cells of the tonsils demonstrated positvity for CD3, CD56, UCHL1, and granzyme, a finding compatible with NK/T-cell lymphoma. The patient received radiation therapy and chemotherapy, but died as a result of opportunistic infection of invasive aspergillosis after tumor recurrence. An autopsy was done with the consent of the patient's family. To our knowledge, this is the first case in an HIV patient of NK/T-cell lymphoma of the tonsils associated with EBV, confirmed by autopsy. NK/T-cell lymphoma should be considered in the HIV-positive patients with an ulcerating tonsillar mass.
