Oral Cancer in Young vs Old Individuals: A Systematic Review.

AIM: To compare various parameters associated with oral cancer in young and old patients and systematically compile the data on prognosis or outcome of oral cancer in young and old patients that include case series, matched-pair analyses, institutional series, and database reviews. BACKGROUND: Though oral cancer is considered a disease of old age, a recent clinical scenario witnesses its increasing incidence among young persons. When compared to old patients, young patients with oral cancer are exposed to the carcinogens for a very petite period of time suggesting underlying pathogenesis to be distinct from that in older individuals. Literature reports several studies about the occurrence of oral cancer in young patients; however, no unanimous opinion exists about its prognosis and treatment outcomes when compared to older patients. Keeping this in mind, we have extensively studied all the possible aspects (location, local and regional recurrence, nodal and distant metastasis, overall survival, etc.) from the English literature and systematically compiled the available data on prognosis or outcomes of oral cancer. REVIEW RESULTS: The overall outcome of the case series shows poorer prognosis in young patients, matched-pair analyses, and institutional series suggesting no significant differences whereas the databases favored a better prognosis in young patients. The mean overall survival rate was found to be better for young patients in the database and institutional review whereas worse in the matched-pair analyses. The mean 5-year survival rate was found to be more in young individuals in matched-pair analyses, database reviews, and institutional series as compared to older oral cancer patients. CONCLUSION: Though data extracted from various study designs are heterogeneous, the present review gives a scoping view of the papers published on oral cancer in young vs old patients. More prospective studies are suggested with a larger sample size in the future. CLINICAL SIGNIFICANCE: The present review will help to better understand the nature, course, and biologic behavior of oral cancer in young patients leading to the development of specific treatment strategies to manage the patients based on their age-groups.

Transverse Ridge of Premolars and Oblique Ridge of Maxillary Molars are in Divine Golden Ratio.

AIMS: In premolars and molars, transverse ridge (TR) and oblique ridge (OR) play major roles in providing strength and stability to the cusps in particular and tooth as a whole. Hence, they could be divided at the central groove or the transverse groove in a divine golden ratio. MATERIALS AND METHODS: Twenty pairs of maxillary and mandibular casts were retrieved from the Department of Orthodontics. The lengths of buccal triangular ridge (BTR), lingual triangular ridge (LTR) and TR of maxillary and mandibular first and second premolars were measured. Similarly, lengths of distal cuspal ridge of mesiopalatal cusp, triangular ridge of distobuccal cusp (DBTR) and OR of the maxillary first and second molars were measured using a brass wire and a Vernier caliper. The TR:BTR, BTR:LTR, OR:distal ridge of mesiopalatal cusp (MPDR), and MPDR:DBTR ratios were calculated to find out the possibility of golden ratio. RESULTS: Transverse ridges of the premolars and OR of the maxillary first and second molars were divided at the central groove in a divine golden ratio. The mean TR/BTR ratio for maxillary first premolar was 1.61 ± 0.007, whereas the mean BTR/LTR ratio was 1.63 ± 0.02. The mean TR/BTR ratio for maxillary second premolar was 1.61 ± 0.01, whereas the mean BTR/LTR ratio was 1.62 ± 0.04. The TR/BTR and BTR/LTR ratios for mandibular first premolar were 1.6 ± 0.008 and 1.64 ± 0.02, respectively. Similarly, the mean TR/BTR ratio for mandibular second premolar was 1.61 ± 0.01, whereas the mean BTR/LTR ratio was 1.63 ± 0.02. CONCLUSION: The ORs of maxillary first molar ridge and TR of maxillary and mandibular premolars are divided into two parts at transverse and central grooves, respectively, in a divine ratio. CLINICAL RELEVANCE: The ORs of maxillary first molar ridge and TR of maxillary and mandibular premolars are divided into two parts at transverse and central grooves, respectively, in a divine ratio. This signifies the strength and stability of the occlusal table in the posterior teeth, as the golden ratio is the mark of functional excellence. Golden ratio should be taken into consideration while restoration or fabrication of the posterior teeth.

Recent trends in predictive biomarkers for determining malignant potential of oral potentially malignant disorders.

Despite of the tremendous advancements in the field of cancer prevention, detection and treatment, the overall prognosis of oral squamous cell carcinoma (OSCC) still remains poor. This can be partly imparted to the lack of early detection of oral potentially malignant disorders (OPMDs), especially those at a higher risk of progression into OSCC. Over years, various specific and non-specific markers have been introduced that could predict the malignant transformation of OPMDs; however detail information on these OPMD markers in a concise manner is lacking. Moreover, their use on daily clinical basis still remains questionable. With continuous research in the field of cytology and genomics, several contemporary biomarkers have been discovered that are not yet foregrounded and proved to be more promising than those used conventionally. Here, in the present paper, we overview several recently concluded predictive biomarkers with special emphasis on their role in molecular pathogenesis of OSCC transformation. These markers can be used for risk assessment of malignant transformation in patients with OPMDs as well as for prophylactic conciliation and fair management of the high-risk OPMD patient group.