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2.
Endocr Res ; 41(2): 110-5, 2016 May.
Article in English | MEDLINE | ID: mdl-26726836

ABSTRACT

OBJECTIVE: Hashimoto's thyroiditis (HT) is the most common etiology of hypothyroidism in regions where iodine deficiency is not a concern. To date, many clinical investigations have been conducted to elucidate its pathogenesis. Several growth factors have been shown to have a role in its development. Hepatocyte growth factor (HGF) is one of the aforementioned molecules. We aimed to demonstrate whether HGF is responsible for HT and goiter development. Also, we aimed to test the hypothesis that levo-thyroxine sodium therapy will suppress HGF levels. MATERIALS AND METHODS: Sixty-one premenopausal women who were admitted to our outpatient clinic between November 2010 and September 2011 were enrolled. Three groups were determined according to their thyroid function tests (TFTs) as euthyroid Hashimoto's, control and subclinical hypothyroid Hashimoto's groups. Basal TFTs, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-tg), thyroid ultrasonography (USG) and HGF were studied and recorded. Subclinical hypothyroid HT patients received levo-thyroxine sodium replacement therapy, and were re-assessed for the same laboratory and radiologic features after a median 3.5 month follow-up. RESULTS: Basal HGF levels were not different between groups. In the subclinical hypothyroidism group, HGF levels (752.75 ± 144.91 pg/ml vs. 719.37 ± 128.05 pg/ml; p = 0.496) and thyroid volumes (12.51 ± 3.67 cc vs. 12.18 ± 4.26 cc; p = 0.7) before and after treatment did not change significantly. No correlations were found between HGF and other parameters. HGF levels were similar between subjects with nodular goiter and normal thyroid structure. CONCLUSIONS: HGF was not shown to be associated with HT and goiter development. In addition, levo-thyroxine sodium replacement therapy did not alter serum HGF levels significantly.


Subject(s)
Goiter/blood , Goiter/drug therapy , Hashimoto Disease/blood , Hashimoto Disease/drug therapy , Hepatocyte Growth Factor/blood , Hypothyroidism/blood , Hypothyroidism/drug therapy , Thyroid Gland/diagnostic imaging , Thyroxine/pharmacology , Adult , Female , Follow-Up Studies , Humans , Thyroxine/administration & dosage , Treatment Outcome , Young Adult
3.
Turk J Gastroenterol ; 24(4): 363-6, 2013.
Article in English | MEDLINE | ID: mdl-24254271

ABSTRACT

Bleeding from anorectal varices can be massive and life-threatening. Punctual separation between hemorrhoids and anorectal varices is important. Numerous treatment options are available for management of bleeding anorectal varices, but none of them has demonstrated definitive efficacy. We report a case of successful transjugular intrahepatic portosystemic shunt in controlling massive recurrent rectal variceal bleeding in an elderly male patient.


Subject(s)
Gastrointestinal Hemorrhage/etiology , Gastrointestinal Hemorrhage/surgery , Hypertension, Portal/complications , Hypertension, Portal/surgery , Portasystemic Shunt, Transjugular Intrahepatic , Aged , Gastrointestinal Hemorrhage/diagnostic imaging , Humans , Hypertension, Portal/diagnostic imaging , Liver Cirrhosis/diagnostic imaging , Liver Cirrhosis/etiology , Liver Cirrhosis/surgery , Male , Rectum , Recurrence , Severity of Illness Index , Tomography, X-Ray Computed , Treatment Outcome
4.
Int J Crit Illn Inj Sci ; 3(2): 152-4, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23961460

ABSTRACT

Echinococcosis is a helminthic zoonosis mainly caused by Echinococcus granulosus and commonly encountered in endemic areas. The liver and lung are the most frequently involved organs. A primary isolated hydatid cyst of spleen is an extremely rare disease even in endemic areas. Anaphylactic reaction is a known complication of cystic hydatid disease, a parasitic infestation caused by the larval/cyst stage of E. granulosus that usually occurs after trauma or during interventions. To the best of our knowledge, anaphylaxis with spontaneous rupture of primary isolated splenic hydatidoses had not been reported previously. The main purpose of this report is to highlight life-threatening complications such as anaphylactic shock that should be considered due to primary isolated splenic cyst hydatid rupture in especially endemic regions.

5.
Pol J Radiol ; 78(2): 54-6, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23807886

ABSTRACT

BACKGROUND: High-flow priapism is a rare condition characterized by a prolonged and painless erection. Since it may permanently impair erectile function, it must be managed and treated as soon as possible, in order to restore potency. The case we are presenting here was successfully treated by embolizing the penile artery using an autologous clot. CASE REPORT: A case of delayed painless high-flow priapism that occured after blunt straddle-type perineal trauma, that was persistent for more than 30 days is being presented. Doppler ultrasonographic examination of the cavernosal artery revealed a 1.5 cm-diameter pseudoaneurysm at the right cavernosal artery, together with a high-velocity shunt between the two cavernous arteries. Extravasation from the proximal sites of both of the cavernous arteries and a right cavernosal artery pseudoaneurysm was detected on angiography. The patient was successfully treated by embolization of the penile artery with an autologous clot in two sessions with a 3-day interval. CONCLUSIONS: This experience along with a survey of the literature made us conclude that embolization of cavernous artery by means of an autologous clot is a very effective procedure and a method of choice for treatment of high-flow priapism and for restoration of penile erectile function. What makes our case even more interesting and important, is the fact that priapism of one month's duration could well be treated by means of this method.

6.
Turk Kardiyol Dern Ars ; 41(2): 154-6, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23666305

ABSTRACT

We report the case of a 51-year-old man with advanced renal cell carcinoma (RCC), without inferior vena cava (IVC) involvement, who was treated with chemotherapy. Computed tomography of the thorax and abdomen revealed metastatic invasion of the liver, mediastinal lymph nodes, right adrenal gland, and the head of pancreas. Heart involvement via the IVC is a well-known pattern of metastasis during RCC progression. There are very few cases worldwide that have reported RCC with cardiac metastasis without IVC involvement.


Subject(s)
Carcinoma, Renal Cell/pathology , Heart Neoplasms/secondary , Kidney Neoplasms/pathology , Adrenal Gland Neoplasms/secondary , Carcinoma, Renal Cell/drug therapy , Carcinoma, Renal Cell/secondary , Heart Neoplasms/drug therapy , Humans , Incidental Findings , Kidney Neoplasms/drug therapy , Liver Neoplasms/secondary , Lung Neoplasms/secondary , Lymphatic Metastasis/diagnostic imaging , Male , Middle Aged , Pancreatic Neoplasms/secondary , Tomography, X-Ray Computed , Vena Cava, Inferior
7.
Sultan Qaboos Univ Med J ; 13(1): 165-8, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23573401

ABSTRACT

Pulmonary embolism due to hydatid disease is an unusual condition resulting from the rupture of a hydatic heart cyst or the opening of liver hydatidosis into the venous circulation. A 78-year old male patient complaining of dyspnea, cough and severe chest pain was admitted to our emergency department. A multidetector computed tomography of the chest revealed the presence of multiple nodules in both lungs especially in left and multiple hypodense filling defect in left main pulmonary artery and its branches. In addition, coronal reformatted multidetector computed tomography images also showed two hypodense cystic parenchymal masses on the left lobe of the liver with a cystic embolus in the right atrium. Pulmonary embolism should be kept in mind in patients who have hepatic hydatidosis if suddenly chest pain and dyspnoea occurs, especially in regions where hydatidosis is endemic.

8.
Med Ultrason ; 14(4): 358-60, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23243652

ABSTRACT

Duplication of the gallbladder, a rare congenital anomaly, is important in clinical practice as it may cause some clinical, surgical, and diagnostic problems. This anomaly is also important for surgeons due to the increased risk of complications especially after laparoscopic cholecystectomy. We report ultrasonography, computed tomography, and magnetic resonance cholangiopancreatography findings in two cases of a symptomatic duplicated gallbladder.


Subject(s)
Diagnostic Imaging/methods , Gallbladder/abnormalities , Gallbladder/diagnostic imaging , Adult , Diagnosis, Differential , Female , Gallbladder/pathology , Humans , Middle Aged , Ultrasonography
9.
Pol J Radiol ; 77(4): 65-6, 2012 Oct.
Article in English | MEDLINE | ID: mdl-23269940

ABSTRACT

BACKGROUND: Persistent left superior vena cava is a rare but important congenital vascular anomaly. However, PLSVC with absent RSVC (isolated PLSVC) is a very rare venous malformation We report on a rare case of persistent left superior vena cava (PLSVC) with absent right superior vena cava (RSVC). CASE REPORT: This venous malformation was identified incidentally in a 69-year-old woman during chest multi-detector computed tomography (MDCT). On chest MDCT, the SVC was noted on the left side. A bridging vein drained the right jugular and right subclavian veins and joined the left brachiocephalic vein in order to form the PLSVC, which descended on the left side of the mediastinum and drained into the left atrium (LA). The patient had no additional cardiac anomaly. CONCLUSIONS: Isolated PLSVC is usually asymptomatic but it can pose difficulties for establishing central venous access, pacemaker implantation and cardiothoracic surgery. This condition is also associated with an increased incidence of congenital heart disease, arrhythmias and conduction disturbances. A wide spectrum of clinicians should be aware of this anomaly, its variations and possible complications.

12.
N Z Med J ; 126(1368): 79-81, 2012 Jan 25.
Article in English | MEDLINE | ID: mdl-23385838

ABSTRACT

Bronchogenic cysts are congenital lesions result from abnormal budding of the ventral foregut and depending on the timing of abnormal development cysts may locate within the mediastinum or lung parenchyma. In the case which the density of the cyst is higher it is possible to different the cyst from the tumoural pathology. In our case report we present a bronchogenic cyst mimicking tumoural pathology. It is always suggested to total removal of the cyst to treatment.


Subject(s)
Bronchogenic Cyst/diagnosis , Esophageal Neoplasms/diagnosis , Adult , Bronchogenic Cyst/pathology , Bronchogenic Cyst/surgery , Calcinosis/diagnosis , Calcinosis/pathology , Calcinosis/surgery , Contrast Media/administration & dosage , Diagnosis, Differential , Esophageal Neoplasms/pathology , Esophageal Neoplasms/surgery , Female , Hemoptysis/etiology , Humans , Image Enhancement , Tomography, X-Ray Computed
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