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1.
J Pak Med Assoc ; 69(8): 1209-1212, 2019 Aug.
Article in English | MEDLINE | ID: mdl-31431782

ABSTRACT

Male breast cancer is a rare disease and it differs from breast cancer in women by some characteristics. The incidence of the disease has increased in the last 25 years. The records of male patients who underwent surgery for breast cancer between 2007 and 2017 were retrospectively reviewed in a tertiary care hospital in Istanbul, Turkey. The patients' ages, background, family history, clinical features, histopathological features of the tumour, its stage, the treatment and the survival were investigated. SPSS 15.0 for Windows programme was used for statistical analysis.Survival analysis was performed with Kaplan-Meier method.Determinants were analysed by univariate Cox regression analysis. A total of 15 patients were evaluated in our study. Fourteen patients had invasive ductal carcinoma and one patient had intraductal papillary carcinoma. The median followup period of the patients was 36 months The axillary lymph node metastasis positivity rate (number of metastatic lymph nodes/number of lymph nodes dissected) was statistically significantly higher in patients who died than in patients who survived.In univariate Cox regression analysis, the effects of age, tumour size, estrogen, progesterone, the presence of HER2/neu receptor and axillary metastasis on survival were not determined. We believe that raising awareness on male breast cancer in the community, genetic testing and screening mammography in high-risk patients will be useful in early diagnosis of the disease and improvement of its prognosis.


Subject(s)
Breast Neoplasms, Male/pathology , Carcinoma, Ductal, Breast/pathology , Carcinoma, Intraductal, Noninfiltrating/pathology , Lymph Nodes/pathology , Aged , Antineoplastic Agents, Hormonal/therapeutic use , Axilla , Breast Neoplasms, Male/metabolism , Breast Neoplasms, Male/therapy , Carcinoma, Ductal, Breast/metabolism , Carcinoma, Ductal, Breast/therapy , Carcinoma, Intraductal, Noninfiltrating/metabolism , Carcinoma, Intraductal, Noninfiltrating/therapy , Chemotherapy, Adjuvant , Humans , Lymph Node Excision , Male , Mastectomy , Mastectomy, Modified Radical , Middle Aged , Neoplasm Staging , Prognosis , Proportional Hazards Models , Radiotherapy, Adjuvant , Receptor, ErbB-2/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Retrospective Studies , Sentinel Lymph Node Biopsy , Survival Rate , Tertiary Care Centers , Tumor Burden , Turkey
2.
Turk J Surg ; 35(4): 329-331, 2019 Dec.
Article in English | MEDLINE | ID: mdl-32551432

ABSTRACT

Thyroid hemiagenesis is a rare entity in the literature. Developmental hemi-thyroid anomalies can result from either an abnormal descent or an agenesis of one lobe of the thyroid gland. This study aimed at presenting a thyroid hemiagenesis case incidentally diagnosed by neck ultrasonography (USG), who had complaints of pain and swelling in the neck. USG examination revealed lack of left thyroid lobe and multiple nodules in the right lobe. Fine Needle Aspiration Biopsy (FNAB) showed follicular neoplasia, and right subtotal thyroidectomy was performed. We report the rarity of the condition and emphasize the role of imaging techniques in preoperative diagnosis and subsequent management.

3.
Turk J Surg ; 34(1): 77-79, 2018.
Article in English | MEDLINE | ID: mdl-29756116

ABSTRACT

Gossypiboma which cause medico-legal implications is a heritage of previous surgery. In this study, we present two cases of gossypiboma mimicking intraabdominal malignancy. Case 1: A 28-year-old woman presented with an epigastric mass measuring 10 cm in diameter and a history of open cholecystectomy performed three years ago. Radiological exams revealed a cystic mass at the lesser sac and suggested serous cystadenocarcinoma. Case 2: A 36-year-old female patient with a history of two caesarean sections had a mass in the left lower quadrant. Radiological imaging showed tumoral mass near the left ovary. The exact diagnosis of gossypiboma were achieved by laparotomy and pathological examination in both cases. Gossypibomas usually present with nonspecific symptoms and appear many years after surgery. Therefore, its preoperative diagnosis is very difficult. High degree of suspicion is essential and it should be considered in the differential diagnosis of intraabdominal masses in patients who have previously undergone surgery.

4.
Sisli Etfal Hastan Tip Bul ; 52(1): 19-25, 2018.
Article in English | MEDLINE | ID: mdl-32595366

ABSTRACT

OBJECTIVES: Secondary thyroid surgery is rare, compared with primary thyroid surgery. However, secondary surgery has a greater risk of complications due to the formation of scar tissue as well as increased fragility of the tissues following the previous surgery. Several surgical techniques and strategies have been recommended to decrease the complication rate associated with secondary surgery. The aim of this study was to evaluate the complication rate in patients who underwent secondary thyroid surgery using a lateral approach and intraoperative nerve monitoring (IONM). METHODS: The data of 44 patients who underwent secondary surgical intervention after thyroid surgery performed for benign or malignant thyroid disease (Group 1), and of 44 patients who underwent primary surgery (Group 2) were compared. Lobectomy patients with a histopathological result of malignant disease, whom were applied completion thyroidectomy were excluded from the study. Secondary surgery was performed using a lateral approach. Access was achieved between the anterior edge of the sternocleidomastoid muscle and the strap muscles. In primary surgery, the thyroid lodge was entered through the midline. Standard IONM was applied in all cases. Hypocalcemia was defined as a serum calcium level of ≤8 mg/dL within the first postoperative 48 hours, regardless of clinical symptoms. Transient and permanent recurrent laryngeal nerve paralysis was evaluated based on the number of nerves at risk. The lobectomy was considered to be high-risk with the presence of recurrence, Graves' disease, substernal goiter, and application of central dissection. RESULTS: The mean age of Group 1 and 2 was 49.9±14.1 years and 45±12.6 years , respectively (range: 22-90 years; p=0.69). Female patients constituted 90.9% (n=40) of the population in Group 1 and 75% (n=33) of the patient population in Group 2 (p=0.87). In Group 1, 11 (25%) patients, and 7 (15.9%) patients in Group 2 underwent surgical intervention due to the presence of a malignant disease (p=0.29). Bilateral intervention was applied in 26 (59.1%) patients in Group 1 and 28 (63.6%) patients in Group 2. The rate of transient and permanent hypocalcemia in Groups 1 and 2 was 34.1% (n=15) vs 22.5%, and 2.5% (n=1) vs 0%, respectively, without any significant intergroup difference (p=0.237, p=1). In Group 1, 71 lobes were operated on, and there were 72 in Group 2. All of the interventions in Group 1 (100%), and 31.9% (n=23) of those in Group 2 were high-risk, and there was a significant intergroup difference (p<0.0001). The rate of transient and permanent vocal cord paralysis were 4.2% (n=3) vs 2.8% (n=2) and 6.9 % (n=5) vs 0% in Groups 1 and 2, respectively (p=0.719; p=0.245). CONCLUSION: When performed with a meticulous and attentive technique, secondary surgical intervention can be applied without increasing the incidence of permanent complications. Though there is substantial risk associated with all of these procedures, the rate of vocal cord paralysis was similar to that seen after primary intervention, and was thought to be related to surgical experience and technique, as well as the use of IONM.

5.
Case Rep Surg ; 2017: 7048149, 2017.
Article in English | MEDLINE | ID: mdl-29209551

ABSTRACT

A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast. Invasive ductal carcinoma was detected in core needle biopsy samples from lesions. In the multidisciplinary council consisting of oncologist, pathologist, radiologist, and general surgery specialist, it was decided to perform breast operation first and then colon operation, followed by adjuvant chemotherapy. In the first operation, left total mastectomy and sentinel lymph node biopsy were performed. One week after her initial operation, the patient underwent right hemicolectomy. After operations, the patient did not develop postoperative complications and was sent to medical oncology department for adjuvant chemotherapy.

6.
Turk J Surg ; 33(3): 164-168, 2017.
Article in English | MEDLINE | ID: mdl-28944327

ABSTRACT

OBJECTIVE: Recognition of extralaryngeal branching of the recurrent laryngeal nerve is crucial because prevention of vocal cord paralysis requires preservation of all branches of the recurrent laryngeal nerve. We assessed the prevalence of extralaryngeal branching of the recurrent laryngeal nerve and the median branching distance from the point of bifurcation to the entry point of the nerve into the larynx. MATERIAL AND METHODS: Prospective operative data on recurrent laryngeal nerve branching were collected from 94 patients who underwent thyroid or parathyroid surgery between September 2011 and May 2012. RESULTS: A total of 161 recurrent laryngeal nerves were examined (82 right, 79 left). Overall, 77 (47.8%) of 161 recurrent laryngeal nerves were bifurcated before entering the larynx. There were 36 (43.9%) branching nerves on the right and 41 (51.9%) branching nerves on the left, and there was no significant difference between the sides in terms of branching (p=0.471). Among 67 patients who underwent bilateral exploration, 28.4% were found to have bilateral branching, 40.3% had unilateral branching, and the remaining 31.3% had no branching. The median branching distance was 15 mm (5-60mm). CONCLUSION: Extralaryngeal division of recurrent laryngeal nerve is a common and asymmetric anatomical variant. These variations can be easily recognized if the recurrent laryngeal nerve is identified at the level of the inferior thyroid artery and then dissected totally to the entry point of the larynx. Inadvertent division of a branch may lead to vocal cord palsy postoperatively, even when the surgeon believes the integrity of the nerve has been preserved.

7.
Langenbecks Arch Surg ; 402(6): 965-976, 2017 Sep.
Article in English | MEDLINE | ID: mdl-28035477

ABSTRACT

PURPOSE: The purpose of this study was to evaluate the effect of intraoperative neuromonitoring (IONM) on the injury rate of the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomy. METHODS: A total of 133 consenting patients (98 female, 35 male; mean age, 45.6 ± 11.7 years) undergoing thyroidectomy were randomly assigned to 2 groups. In group 1 (n = 65 patients, 105 nerves), superior thyroid pole dissection was performed with no attempt to identify the EBSLN; in group 2 (n = 68 patients, 106 nerves), IONM was used to identify the EBSLN during surgery. EBSLN function was evaluated by intraoperative electromyography of the cricothyroid muscle. The EBSLN Voice Impairment Index-5 (VII-5) was conducted preoperatively and at 1, 3, and 6 months postoperatively. The primary outcome was the prevalence of EBSLN injury. The secondary outcomes were the identification rate of the EBSLN using IONM and changes in postoperative voice performance. RESULTS: EBSLN injury was detected in eight (12.3%) patients and nine (8.6%) nerves in group 1 and in one (1.5%) patient and one (0.9%) nerve in group 2 (patients, p = 0.015; nerves, p = 0.010). IONM contributed significantly to visual (p < 0.001) and functional (p < 0.001) nerve identification in group 2. The VII-5 indicated more voice changes in group 1 than 2 at 1, 3, and 6 months postoperatively (p = 0.012, p = 0.015, and p = 0.02, respectively). CONCLUSION: IONM contributes to visual and functional identification of the EBSLN and decreases the rate of EBSLN injury during superior pole dissection. Routine use of IONM to identify the EBSLN will minimize the risk of injury during thyroidectomy.


Subject(s)
Laryngeal Nerve Injuries/prevention & control , Monitoring, Intraoperative/methods , Thyroid Gland/surgery , Thyroidectomy/adverse effects , Thyroidectomy/methods , Vocal Cord Paralysis/prevention & control , Adult , Aged , Electromyography/methods , Female , Follow-Up Studies , Humans , Laryngeal Nerve Injuries/etiology , Male , Middle Aged , Prospective Studies , Reference Values , Risk Assessment , Thyroid Gland/physiopathology , Treatment Outcome , Vocal Cord Paralysis/etiology
8.
Ann Ital Chir ; 87: 417-421, 2016.
Article in English | MEDLINE | ID: mdl-27842008

ABSTRACT

AIM: Hypoparathyroidism is the most common complication of total thyroidectomy (TT). Postthyroidectomy hypocalcemia occurs 24 to 48 hours after the operation. It prolongs the length of hospital stay, even though transient in most cases. The aim of this study was to predetermine the patients who may develop postthyroidectomy hypocalcemia by using early postoperative serum intact parathormone (iPTH) and calcium (Ca2+) measurements, and to investigate the effects of early initiated oral calcium and vitamin D treatments on the development of transient hypocalcemia. MATERIAL AND METHODS: Patients who underwent TT after initiation of the early iPTH measurement protocol in January 2013 were included into the study group (Group 1, n=202). The control group (Group 2) was composed of 72 patients who underwent TT before the protocol. Prior to the initiation of the protocol, Ca2+ was measured instead of iPTH. In the study group, the serum Ca2+ and iPTH levels were measured before surgery, and 1 and 24-hours after. A calcium level below 8 mg/dL was accepted as biochemical hypocalcaemia, and a iPTH level under 15pg/mL was accepted as hypoparathyroidism. In the study group, patients with below normal iPTH levels were treated with prophylactic oral calcium and vitamin D. RESULTS: In Group 1, 15.8% (n=32) of the patients had hypoparathyroidism on the 1h and 24 h iPTH measurements. There was no statistically difference with regard to PTH levels measured in the postoperative 1st hour and at the 24th hour (p= 0.078). Biochemical hypocalcaemia developed in 16 (7.9%) and 13 (18%) patients in Groups 1 and 2, respectively, 24 hours after thyroidectomy (p<0.05). Mean length of hospital stay was 2.17 and 3.26 days in the study and control groups (p<0.001). CONCLUSIONS: We believe that the measurement of iPTH levels one hour after thyroidectomy, when compared to levels at 24 hours after procedure, is a safe, reliable, and adequate method for the effective management of plausible postthyroidectomic hypocalcemia. It yields significantly shorter hospital stay periods. KEY WORDS: Calcium, Hypoparathyroidism, Postoperative complication, Total thyroidectomy.


Subject(s)
Hypocalcemia/blood , Hypoparathyroidism/etiology , Parathyroid Hormone/blood , Postoperative Complications/blood , Thyroidectomy , Adolescent , Adult , Asymptomatic Diseases , Biomarkers/blood , Calcium/blood , Calcium/therapeutic use , Early Diagnosis , Female , Goiter, Nodular/surgery , Humans , Hypocalcemia/etiology , Hypocalcemia/prevention & control , Length of Stay , Male , Middle Aged , Parathyroid Glands/injuries , Postoperative Complications/etiology , Postoperative Period , Vitamin D/therapeutic use , Young Adult
9.
J Invest Surg ; 29(6): 383-388, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27159534

ABSTRACT

AIM: We aimed to investigate the anatomical characteristics of the recurrent laryngeal nerve (RLN) highlighting on its diameter and branching pattern. MATERIALS AND METHODS: We prospectively collected 215 patients (178 female, 37 male) who underwent thyroid/parathyroid surgery during over a 2-year period. Apart from demographic features and surgical data, diameter of RLNs, and their branches and as well as branching distance (distance between the point of bifurcation and the laryngeal entry of RLN) were recorded. RESULTS: In 215 patients, 378 RLNs were assessed and 42% (n = 159) bifurcated RLNs were observed. The bifurcation rate was similar on the right and left side(s) of the neck (40% and 44%, respectively; p = 0.47). In those, who underwent bilateral exploration, in the case of bifurcation on the first side of the neck, the possibility of contralateral bifurcation was approximately 50%, whereas this rate was found to be only 30% in those with nonbranching RLNs. Mean branching distance was 18 ± 9 mm, and it was similar on the right and left sides (17 and 19 mm, respectively). Approximately 80% of bifurcations were observed within 5-24 mm of the RLN. Mean diameter of the anterior branches was found to be significantly larger compared to posterior branches (1.09 ± 0.35 and 0.82 ± 0.36 mm, respectively; p < 0.01). CONCLUSIONS: There is great variability in RLN branching. We observed that approximately two out of three bifurcations were unilateral and anterior branches were thicker compared to posterior branches. These findings should be taken into consideration to avoid any damage to the RLN during thyroid and parathyroid surgery.


Subject(s)
Recurrent Laryngeal Nerve/anatomy & histology , Adult , Aged , Anatomic Variation , Female , Humans , Male , Middle Aged , Prospective Studies , Recurrent Laryngeal Nerve Injuries/etiology , Young Adult
10.
Ulus Cerrahi Derg ; 32(1): 6-10, 2016.
Article in English | MEDLINE | ID: mdl-26985153

ABSTRACT

OBJECTIVE: Thyroidectomy is the most common cause of hypocalcemia. Preservation of parathyroid glands in situ is essential in preventing this complication. The aims of our study were to review patients who underwent parathyroid gland autotransplantation during thyroidectomy, and to compare hypocalcemia rates in patients with and without autotransplantation. MATERIAL AND METHODS: Parathyroid gland autotransplantation was performed in 43 (7.9%) of 543 patients who underwent thyroidectomy between 2008 and 2012. RESULTS: Forty-four parathyroid glands were autotransplanted in 43 patients, including 36 women and 7 men. The median age was 55 (range: 30 to 68). The most common cause of autotransplantation was vascular comprise of the parathyroid gland. Early postoperative hypocalcemia developed in 37% of patients with autotransplantation, and none developed permanent hypocalcemia. Transient and permanent hypocalcemia rates were 9.6% and 0.4% in patients without autotransplantation, respectively. The risk of transient hypocalcemia was significantly high in patients with parathyroid autotransplantation (p<0.001). There was no difference between the two groups in terms of permanent hypocalcemia (p=0.156). CONCLUSION: Despite meticulous dissection, parathyroid glands can be devascularized or removed inadvertently during thyroidectomy. Parathyroid autotransplantation is the best method to maintain parathyroid gland function. Although the risk of transient hypocalcemia is increased following parathyroid autotransplantation, long-term results are satisfactory.

11.
Surg Today ; 45(11): 1436-41, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25326671

ABSTRACT

INTRODUCTION: Our aim was to evaluate the findings of intraoperative nerve monitoring (IONM) in two cases with preoperative vocal cord palsy. Case 1: a 61-year-old female with recurrent goiter underwent secondary thyroidectomy. The preoperative evaluation of the vocal cords revealed right vocal cord paralyses without atrophy. The right recurrent laryngeal nerve (RLN) was found to be anatomically intact and preserved. The electrical responses of the vocal cords were elicited via IONM. Case 2: a 26-year-old male, who presented with preoperative right vocal cord palsy with atrophy, underwent completion thyroidectomy secondary to papillary carcinoma. The right RLN was explored and found to be tied and interrupted. There was no signal from the RLN with IONM. CONCLUSION: Even in cases with vocal cord palsy detected preoperatively, the nerve should be explored intraoperatively, and should never be sacrificed before an evaluation by nerve monitoring. A palsied RLN which has electrical activity should be protected to maintain the vocal cord's neural tone and to prevent its atrophy.


Subject(s)
Goiter/surgery , Intraoperative Complications/diagnosis , Intraoperative Neurophysiological Monitoring/methods , Thyroidectomy/methods , Vocal Cord Paralysis/diagnosis , Adult , Female , Goiter/complications , Humans , Male , Middle Aged , Recurrence , Vocal Cord Paralysis/etiology
12.
Ann Ital Chir ; 85: 610-612, 2014.
Article in English | MEDLINE | ID: mdl-25369974

ABSTRACT

AIM: Spigelian Hernia (SH) is a rare ventral hernia with a high incarceration and obstruction risk. The purpose of this study is to present our experience in diagnosis and treatment of this rare hernia entity. MATERIAL AND METHODS: The retrospective demographic characteristics, diagnostic tools and the surgical techniques of 17 patients who were treated between 2000-2010 are included in the study. RESULTS: All patients had swelling and pain. All patients underwent preperitoneal mesh repair. No mortality or morbidity were recorded postoperatively. No recurrence was detected at the end of a 73 (13-115) month follow-up period. CONCLUSIONS: Spigelian Hernia is a rare entity with a wide clinical spectrum and difficulties in preoperative diagnosis. Surgical mesh repair seems to decrease the complication and recurrence rates. KEY WORD: Hernia repair, Spigelian hernia, Surgery.

13.
Ulus Travma Acil Cerrahi Derg ; 19(2): 164-6, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23599202

ABSTRACT

Intestinal brids are most common cause of postoperative ileus although there are various cause of ileus after abdominal operation. On the other hand internal herniation is a rare cause of ileus after abdominal operations. Diagnosis of this hernias are important because of strangulation and necrosis of its content due to circulatory disturbance. In this case report, we publish a patient with ileus due to a greft which has been used in a previous abdominal surgery for abdominal aort aneurysm.


Subject(s)
Aorta/surgery , Intestinal Diseases/etiology , Postoperative Complications/etiology , Vascular Surgical Procedures/adverse effects , Femoral Artery/surgery , Femoral Artery/transplantation , Humans , Jejunum/pathology , Jejunum/surgery , Male , Middle Aged , Peritoneum/surgery , Tissue Adhesions/etiology , Tissue Adhesions/surgery , Vascular Surgical Procedures/methods
14.
Surg Today ; 43(6): 625-31, 2013 Jun.
Article in English | MEDLINE | ID: mdl-22926550

ABSTRACT

PURPOSES: There is an increasing trend towards performing more radical resections instead of a subtotal resection for benign thyroid disease. The aim of this study was to examine the effect of this change in practice on the surgical treatment of bilateral thyroid diseases in this unit. METHODS: The data on 367 patients that underwent a bilateral thyroidectomy were categorized by dividing the operation types into 4 groups: (1) total thyroidectomy (TT), (2) near-total thyroidectomy, (3) Dunhill procedure, and (4) bilateral subtotal thyroidectomy. RESULTS: A statistically significant change in the choice of thyroidectomy occured during the study period (p < 0.001). TT has replaced subtotal thyroidectomy (STT; bilateral subtotal thyroidectomy and Dunhill procedure) as the preferred routine surgical procedure for bilateral benign thyroid diseases in this clinic. The permanent complication rates were similar for all surgical procedures. The rate of secondary thyroidectomy for both recurrence of multinodular goiter and incidental thyroid carcinoma were significantly higher in the STT groups, than the total in the TT and near-total thyroidectomy patients. CONCLUSIONS: Total or near total thyroidectomy procedures are now being increasingly employed to treat bilateral benign thyroid disease, and are as safe as the sub-total thyroidectomy procedures, which are more conservative and associated with significantly higher recurrence rates.


Subject(s)
Thyroid Diseases/surgery , Thyroidectomy/methods , Adult , Female , Humans , Male , Middle Aged , Postoperative Complications/epidemiology , Postoperative Complications/prevention & control , Secondary Prevention , Thyroidectomy/classification , Thyroidectomy/statistics & numerical data , Treatment Outcome
15.
Acta Cir Bras ; 27(10): 707-12, 2012 Oct.
Article in English | MEDLINE | ID: mdl-23033132

ABSTRACT

PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.


Subject(s)
Chitosan/therapeutic use , Colon/surgery , Hemostatics/therapeutic use , Wound Healing/drug effects , Anastomosis, Surgical , Animals , Chitosan/pharmacology , Collagen/physiology , Colon/pathology , Disease Models, Animal , Female , Hemostatics/pharmacology , Rats , Rats, Wistar , Tensile Strength , Time Factors , Tissue Adhesions , Treatment Outcome
16.
Acta cir. bras ; 27(10): 707-712, Oct. 2012. tab
Article in English | LILACS | ID: lil-650560

ABSTRACT

PURPOSE: To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. METHODS: Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. RESULTS: At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). CONCLUSION: Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.


OBJETIVO: Investigar se a aplicação de quitosana em anastomose colônica promove resistência à tração e consequentemente a melhora na cicatrização. MÉTODOS: Foram utilizados 48 ratos Wistar fêmeas distribuídos em quatro grupos, 12 ratos em cada. Grupos controle (1 e 3) não receberam tratamento. Grupos experimento (2 e 4) receberam aplicação de quitosana na anastomose colônica. Após eutanásia após 3º ou 7º dias foram examinadas a tensão, o nível de hidroxiprolina e aspectos histopatológicos da anastomose. RESULTADOS: Após três dias os grupos controle e quitosana não apresentaram alterações histopatológicas. No sétimo dia o grupo quitosana apresentou significante elevação do escore de colagenização (p=0,007) e da tensão de ruptura (p=0,038). CONCLUSÃO: A quitosana apresentou bons resultados nos processos de colagenização e cicatrização de anastomose colônica.


Subject(s)
Animals , Female , Rats , Chitosan/therapeutic use , Colon/surgery , Hemostatics/therapeutic use , Wound Healing/drug effects , Anastomosis, Surgical , Chitosan/pharmacology , Collagen/physiology , Colon/pathology , Disease Models, Animal , Hemostatics/pharmacology , Rats, Wistar , Tensile Strength , Time Factors , Tissue Adhesions , Treatment Outcome
17.
Turk J Gastroenterol ; 23(1): 63-5, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22505382

ABSTRACT

Intestinal invagination is a common pathology amongst children, while it is a rare entity in adults. Invagination is responsible for only 1-3% of adult-onset intestinal obstruction. Meckel's diverticulum, on the other hand, is the most common congenital anomaly of the gastrointestinal tract. Most of them are asymptomatic; they are recognized when they complicate, and can present with diverticulitis, gastrointestinal bleeding, intestinal obstruction, perforation, or invagination. A 16-year-old male patient presented to our emergency department with abdominal pain. There was a palpable mass at the right paraumbilical region. Gas-liquid level was seen on the direct abdominal radiography. On the abdominal ultrasonography, it was reported that the mass might be a result of invagination. As the patient had extensive peritonitis findings, with the pre-diagnosis of obstruction as a result of invagination, surgery was decided. During the operation, it was observed that the invaginated ileum loop was too ischemic for reduction; therefore, the invaginated part was resected and ileoileal anastomosis was performed. Examination of the resected segment revealed the Meckel's diverticulum as causing the invagination. In conclusion, with this case, we aimed to present the role of Meckel's diverticulum as an initiating factor of ileoileal invagination, with inversion into the ileum.


Subject(s)
Ileal Diseases/etiology , Intussusception/etiology , Meckel Diverticulum/diagnosis , Abdominal Pain/etiology , Adolescent , Humans , Ileal Diseases/diagnosis , Ileal Diseases/surgery , Intestinal Obstruction/etiology , Intestinal Obstruction/surgery , Intussusception/diagnosis , Intussusception/surgery , Male , Nausea/etiology , Vomiting/etiology
18.
JSLS ; 15(2): 239-43, 2011.
Article in English | MEDLINE | ID: mdl-21902984

ABSTRACT

BACKGROUND AND OBJECTIVES: Situs inversus totalis (SIT) is a rare congenital anomaly that can cause difficulties during standard laparoscopic cholecystectomy due to its mirror-image anatomy. These cases require more technically demanding procedures, and handedness of the surgeon may influence performance of these operations. Single-incision laparoscopic surgery (SILS) has been proposed as a less-invasive alternative to conventional laparoscopic surgery. We report the first case of successful SILS cholecystectomy in a patient with SIT and discuss technical aspects of the operation related to the handedness of the surgeon. CASE: A 49-year-old man who was known to have situs inversus totalis presented with symptomatic cholelithiasis. This patient was operated on by a right-handed surgeon. The surgeon and camera assistant were positioned on the right and left side respectively with the video monitor above the patient's left shoulder. The SILS port (Covidien), which has 3 operating channels, was placed in the abdomen via a 2-cm intraumbilical incision. SILS cholecystectomy was performed successfully. Dissection of Calot's triangle and the gallbladder bed was performed using a dissector and hook in the right hand without any technical problems. CONCLUSION: SIT may confer an advantage over the orthotopic position for right-handed surgeons. SILS cholecystectomy can be performed safely in SIT.


Subject(s)
Cholecystectomy, Laparoscopic/methods , Cholelithiasis/epidemiology , Cholelithiasis/surgery , Situs Inversus/epidemiology , Situs Inversus/surgery , Comorbidity , Humans , Male , Middle Aged , Situs Inversus/diagnostic imaging , Tomography, X-Ray Computed
19.
Surg Today ; 41(8): 1041-8, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21773891

ABSTRACT

PURPOSE: The use of electrocautery for tissue dissection is becoming increasingly popular, despite the associated risk of poor wound healing and excessive scarring. We conducted this study to compare the wound complications and early and late clinical results resulting from electrocautery versus the scalpel to create a cutaneous flap during thyroidectomy. METHODS: The subjects of this study were 100 patients, randomized prospectively to either a scalpel group (group S, n = 50) or an electrocautery group (group E, n = 50). RESULTS: Thickness of tissue damage, postoperative thickness of the flap, discomfort in the neck 7 days after surgery, and hypoesthesia and paresthesia in the neck 3 months after surgery were significantly higher in group E than in group S. There were no significant differences in overall postoperative wound complications, postoperative pain, satisfaction with the cosmetic result, or overall outcome of the operation between the groups. Although the incidence of seroma was higher in group E (20%) than in group S (8%), the difference was not significant. CONCLUSION: Although electrocautery was associated with increased histological tissue damage, postoperative flap edema, discomfort, and other complications in the early stage, the clinical and cosmetic results of flaps made using electrocautery or a scalpel were similar and satisfactory 6 months after surgery.


Subject(s)
Dissection/adverse effects , Dissection/methods , Electrocoagulation/adverse effects , Surgical Flaps/adverse effects , Thyroid Diseases/surgery , Thyroidectomy/adverse effects , Adult , Cohort Studies , Dissection/instrumentation , Electrocoagulation/instrumentation , Female , Humans , Male , Middle Aged , Patient Satisfaction , Thyroid Diseases/etiology , Thyroid Diseases/pathology , Treatment Outcome
20.
Surg Today ; 41(4): 576-8, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21431498

ABSTRACT

Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract. Any hernia containing Meckel's diverticulum is classified as a Littre hernia. Littre hernias typically occur in the inguinal region, and they may cause bowel obstruction secondary to strangulation or incarceration of the diverticulum within the hernial sac. This case appears to be the second reported of an incarcerated incisional hernia due to Littre's hernia.


Subject(s)
Hernia, Ventral/complications , Hernia, Ventral/surgery , Meckel Diverticulum/complications , Meckel Diverticulum/surgery , Diagnosis, Differential , Female , Hernia, Ventral/diagnostic imaging , Humans , Meckel Diverticulum/diagnostic imaging , Middle Aged , Nephrectomy , Ultrasonography
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