Epidemiological characteristics, clinical characteristics, and prognostic factors of children with atopy hospitalised with adenovirus pneumonia.

BACKGROUND: Atopy may be associated with disease severity and a poor prognosis of human adenovirus (HAdV) pneumonia in children. Our aim was to observe the clinical characteristics and pulmonary radiological changes in children with atopy and HAdV pneumonia in China. METHODS: Children hospitalised with HAdV pneumonia from June 2018 to December 2019 were analysed. All children were divided into atopic with HAdV, non-atopic with HAdV, and atopic without HAdV infection group. Each group was further divided into the mild and severe pneumonia groups according to disease severity. Standard treatment was initiated after admission, and regular follow-up evaluations were conducted at 1 month after discharge. Baseline and clinical characteristics and pulmonary radiological changes in children with and without atopy were evaluated. Risk factors associated with small airway lesions in patients with HAdV pneumonia were analysed. RESULTS: The eosinophil count in the atopic group was significantly higher than that in the non-atopic group (P < 0.05). Severe coughing, wheezing, and small airway lesions on chest high-resolution computed tomography (HRCT) upon admission, after discharge and 1 month after discharge were significantly higher in the atopic group (with or without HAdV infection) than in the non-atopic group (P < 0.05). There were significant differences in the number of patients with wheezing and small airway lesions during hospitalisation and after discharge among the three groups (P < 0.05). The risks of small airway lesions in children with a family or personal history of asthma, severe infection, atopy, and HAdV infection were 2.1-, 2.7-, 1.9-, 2.1-, and 1.4-times higher than those in children without these characteristics, respectively. CONCLUSIONS: Children with atopy and HAdV pneumonia may experience severe coughing in mild cases and wheezing in mild and severe cases. Children with atopy are more susceptible to the development of small airway lesions, recurrent wheezing after discharge and slower recovery of small airway lesions as observed on pulmonary imaging than non-atopic children after HAdV infection. A family or personal history of asthma, atopy, severe infection, and HAdV infection are independent risk factors associated with the development of small airway lesion as observed on chest HRCT.

Double-door laminoplasty combined with C dome decompression for the treatment of cervical spinal stenosis / 中国骨伤

OBJECTIVE@#To investigate the clinical effect of double-door laminoplasty combined with C dome decompression in treatment of cervical spinal stenosis.@*METHODS@#The clinical data of 28 patients with cervical spinal stenosis who underwent double-door laminoplasty combined with C dome decompression from June 2016 to June 2018 were retrospectively analyzed, including 17 males and 11 females, aged 39 to 74 years with an average of (61.0±6.7) years. The clinical effects were evaluated by JOA score, axial symptoms, cervical spine activity, cervical spinal cord compression degree and so on.@*RESULTS@#All patients were followed up for 6 to12 months with an average of 10.2 months. The JOA score in the final follow-up was significantly improved (0.05). After operation, sagittal diameter at the narrowest level of C-C spinal canal was (16.20±1.82) mm, which was significantly higher than (8.38±1.16) mm before operation (<0.05). There were 4 cases with axial symptoms in 24 patients with the incidence rate of 14.29% (4/24).@*CONCLUSION@#Double-door laminoplasty combined with C dome decompression can directly expand the volume of C-C spinal canal, relieve the compression of spinal cord and nerve root, reduce the damage to the posterior cervical ligament complex as much as possible, maintain the stability of cervical spine sequence, reduce the occurrence of axial symptoms, and the operation is relatively simple, without the need of metal internal fixation.

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections.

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ±â€¯0.003 µM) and intact cell (IC50 = 0.89 ±â€¯0.05 µM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.

[Effect of temperature and pH on the fluorescence characteristic of oily waste water].

The present study was about the effect of temperature (5-55 degrees C) and pH (3-12) value on the fluorescence characteristic of oily waste water from the export of China Petroleum & Chemical Oil Refinery. It was found that temperature only affects the fluorescence intensity but not the site of fluorescence peaks. The fluorescence peaks shift right that from 413 to 426.5 nm when the oily waste water is acid. And along with the enhancing of the acidity the fluorescence intensity ascended. The fluorescence intensity decreased with alkaline enhancing but the site of fluorescence peaks remained unchanged at 398 nm. Temperature and pH value were the two important impact factors on the fluorescence characteristic of oily waste water. If desired it needs correction and compensation on temperature and pH value. That's expected to improve the detection accuracy of oil class and content.