ABSTRACT
The population-based cancer registry in Cuba is a national cancer registry established in 1964; cancer registration is entirely done by passive methods. Data on survival from 13 cancer sites or types registered during 1994-1995 are reported. Follow-up has been carried out predominantly by passive methods, with median follow-up ranging from 13-54 months. The proportion with histologically verified diagnosis for various cancers ranged between 34-100%; death certificates only (DCOs) comprised 8-50%; 50-89% of total registered cases were included for the survival analysis. The 5-year age-standardized relative survival for selected cancers were breast (69%), colon (41%), cervix (56%), urinary bladder (64%), rectum (48%) and non-Hodgkin lymphoma (49%). The 5-year relative survival by age group showed no distinct pattern or trend, and was fluctuating. A decreasing survival with increasing clinical extent of disease was noted for all cancers studied. The data on survival trend revealed that the 5-year relative survival of most cancers diagnosed in 1994-1995 was greater than that in 1988-1989.
Subject(s)
Neoplasms/mortality , Adolescent , Adult , Aged , Child , Child, Preschool , Cuba , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Middle Aged , Registries , Time FactorsABSTRACT
The total and covalently bound radioactivity in various subcellular components in the main tissues of rats was measured 7 and 18 days after a single intraperitoneal and intratesticular injection of 3H-(+) and 3H-(-) gossypol. An increasing tendency of covalently bound radioactivity with time in the myocardial mitochondria and testicular cell membrane and microsomes of rats treated with (+) or (-) gossypol was found, especially in (-) gossypol treated rats. It remains to be clarified whether these are linked to the myocardial toxicity and to the antispermatogenic activity of gossypol.
Subject(s)
Gossypol/pharmacokinetics , Testis/metabolism , Animals , Injections, Intraperitoneal , Male , Mitochondria, Heart/drug effects , Rats , Rats, Inbred Strains , Stereoisomerism , Subcellular Fractions/metabolism , Tissue Distribution , TritiumSubject(s)
Naphthoquinones/pharmacokinetics , Absorption , Animals , Male , Mice , Tissue DistributionSubject(s)
Cardenolides/pharmacokinetics , Animals , Biological Availability , Female , Guinea Pigs , Male , RadioimmunoassaySubject(s)
Hematoporphyrins/metabolism , Lung Neoplasms/metabolism , Animals , Female , Male , Mice , Tissue DistributionSubject(s)
Ginsenosides , Saponins/metabolism , Animals , Female , Kinetics , Male , Mice , Protein Binding/drug effects , Tissue DistributionSubject(s)
Cardenolides/metabolism , Cardiotonic Agents/metabolism , Animals , Kinetics , Male , Mice , Rats , TritiumSubject(s)
Anticholesteremic Agents/metabolism , Propiophenones/metabolism , Absorption , Animals , Kinetics , Mice , Plant Extracts/metabolism , Rats , Tissue DistributionSubject(s)
Antimalarials/analysis , Artemisinins , Sesquiterpenes/analysis , Animals , Artesunate , Dogs , RadioimmunoassayABSTRACT
New evidence for the inhibition by harringtonine in the formation of the first peptide bond in protein synthesis was obtained by means of experiments in the cell-free system. The antitumour drug strongly blocked dipeptide synthesis in the system without elongation factor G and GTP. Furthermore, it inhibited N-Acetyl-phenylalanyl-puromycin formation from N-Acetyl-phenylalanyl-tRNA, puromycin, and ribosomes.
