Functional Nanomaterials for the Treatment of Osteoarthritis.

Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 595 million people worldwide. Nanomaterials possess superior physicochemical properties and can influence pathological processes due to their unique structural features, such as size, surface interface, and photoelectromagnetic thermal effects. Unlike traditional OA treatments, which suffer from short half-life, low stability, poor bioavailability, and high systemic toxicity, nanotherapeutic strategies for OA offer longer half-life, enhanced targeting, improved bioavailability, and reduced systemic toxicity. These advantages effectively address the limitations of traditional therapies. This review aims to inspire researchers to develop more multifunctional nanomaterials and promote their practical application in OA treatment.

Design of breastfeeding chairs for maternity rooms based on Kano-AHP-QFD: User requirement-driven design approach.

In maternity rooms, breastfeeding chairs are crucial pieces of equipment that greatly influence the breastfeeding experience. However, an abundance of data indicates that there are still issues with breastfeeding chairs, including inadequate support for breastfeeding, poor body type adaptability, and failure to adequately analyse the requirements of mothers and baby users. This study used an innovative research approach to breastfeeding chair design from the standpoint of user requirements to improve breastfeeding willingness and user experience. We propose a user requirement assessment design approach that integrates the Kano model, analytic hierarchy process (AHP), and quality function development (QFD) based on the requirements of mother and baby groups. This approach was intended to build a user experience evaluation model for mother- and baby-friendly products. Following this approach to breastfeeding chair design, a fuzzy comprehensive evaluation (FCE) was used to assess the chair. Compared to the original breastfeeding chairs, the designs of breastfeeding chairs that met important requirements for mothers and infants, such as safety, hygiene, and breastfeeding support, resulted in an approximately 23 % increase in user satisfaction. This effectively improved the user experience of both mothers and infants. This approach is centred on the basic requirements of mothers and babies. It evaluates the essential requirements that impact the breastfeeding experiences of mothers and babies and provides multifaceted data regarding the attributes of the different requirements of mothers and babies. This results in theoretical research references for ensuing user-driven design products that cater to the requirements of mothers and their infants and play a pivotal role in formulating design guidelines for mother- and baby-friendly products.

Immersive experiences in museums for elderly with cognitive disorders: a user-centered design approach.

In the context of global aging, to explore the design needs of elderly with dementia in museum environments, to establish a user cognitive psychological model based on immersion theory, and to enhance the satisfaction of cognitively impaired dementia with the museum service experience. Using literature research, surveys, questionnaires, interviews, and focus groups, we analyze the experience design from the psychological demands of elderly with dementia, build a method of mining user needs by combining the KANO model with the analytic hierarchy process (AHP) method, and establish a model for evaluating the excellence of the experience of the museum environment. The conclusion shows that displaying museum virtual scenes or old objects can effectively increase the subjective well-being of people suffering from various health conditions. The method can accurately tap the attributes of the needs of elderly with dementia, break through the drawbacks of the traditional museum experience design which is dominated by the designer's subjective consciousness, and allow the audience to better experience the museum immersive experience, which provides a new idea and method for the effectiveness of cognitive interventions for elderly with cognitive disorders.

Uptake, accumulation and translocation mechanisms of organophosphate esters in cucumber (Cucumis sativus) following foliar exposure.

Organophosphate esters (OPEs) have been frequently detected in crops. However, few studies have focused on the uptake and translocation of OPEs in plants following foliar exposure. Herein, to investigate the foliar uptake, accumulation and translocation mechanisms of OPEs in plant, the cucumber (Cucumis sativus) was selected as a model plant for OPEs exposure via foliar application under control conditions. The results showed that the content of OPEs in the leaf cuticle was higher than that in the mesophyll on exposed leaf. Significant positive correlations were observed between the content of OPEs in the leaf cuticle and their log Kow and log Kcw values (P < 0.01), suggesting that OPEs with high hydrophobicity could not easily move from the cuticle to the mesophyll. The moderately hydrophobic OPEs, such as tris (2-chloroisopropyl) phosphate (TCPP, log Kow = 2.59), were more likely to move not only from the cuticle to the mesophyll but also from the mesophyll to the phloem. The majority of the transported OPEs accumulated in younger leaves (32-45 %), indicating that younger tissue was the primary target organ for OPEs accumulation after foliar exposure. Compared to chlorinated OPEs (except TCPP) and aryl OPEs, alkyl OPEs exhibited the strongest transport capacity in cucumber seedling due to their high hydrophilicity. Interestingly, tri-p-cresyl phosphate was found to be more prone to translocation compared to tri-m-cresyl phosphate and tri-o-cresyl phosphate, despite having same molecular weight and similar log Kow value. These results can contribute to our understanding of foliar uptake and translocation mechanism of OPEs by plant.

Root Uptake Pathways and Cell Wall Accumulation Mechanisms of Organophosphate Esters in Wheat (Triticum aestivum L.).

The behavior of organophosphate esters (OPEs) in plants has drawn considerable attention because of their adverse effects to biota. However, the root uptake pathways and cell wall accumulation mechanisms of OPEs in plants are still unclear. In this study, the uptake pathways, subcellular distribution, and accumulation mechanisms of OPEs in wheat roots were elucidated. The results demonstrated that the symplast is the major pathway for uptake of both tris(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPHP) in wheat roots. Inhibitor experiments showed that the transmembrane transport of OPEs is a passive uptake process, and aquaporins and carrier proteins contribute to the uptake of OPEs. More than 69% of TCEP was accumulated in cell sap due to its high hydrophilicity, while the hydrophobic TPHP was mainly stored in the root cell wall. The sorption affinity of TPHP decreased gradually following the sequential fractionation of wheat roots, which confirmed the significant contribution to TPHP sorption on wheat roots. A significant positive correlation between the sorption affinity values and the percentage of aromatic carbon was observed (r2 = 0.856, p < 0.01), indicating that the accumulation of hydrophobic OPEs in roots does not just depend on lipids alone, but the aromatic moieties of lignin in the cell wall also contribute to OPE accumulation.