ABSTRACT
Perforating globe injury is the leading cause of monocular blindness and vision loss. A 58-year-old male was injured by acupuncture needle during acupuncture treatment for his cerebral infarction. To the best of our knowledge, this is the first case report of perforating injury of the eyeball and traumatic cataract caused by acupuncture. The patient was hospitalized due to diagnosis of perforating ocular injury, traumatic cataract, and corneal and iris perforating injury. Moreover, he had to accept treatments of phacoemulsification, anterior vitrectomy along with intraocular lens implantation in the sulcus to improve his visual acuity. As acupuncture therapy has been widely performed for various diseases and achieved highly approval, the aim of this report is to remind acupuncturists operating accurately to avoid unnecessary injury during the treatment process, or the cure can also become the weapon.
Subject(s)
Acupuncture Therapy/adverse effects , Cataract/etiology , Corneal Injuries/etiology , Eye Injuries, Penetrating/etiology , Multiple Trauma , Needlestick Injuries/etiology , Anterior Eye Segment/diagnostic imaging , Anterior Eye Segment/injuries , Cataract/diagnosis , Corneal Injuries/diagnosis , Eye Injuries, Penetrating/diagnosis , Humans , Iatrogenic Disease , Male , Middle Aged , Needlestick Injuries/diagnosis , Ultrasonography, Doppler, ColorABSTRACT
RNA interference (RNAi) is a process triggered by the introduction of small double strand RNA (dsRNA),which leads to a specific degradation of messenger RNA and therefore regulate the expression of target gene.Being one of post transcriptional gene silencing (PTGS),RNAi is found to extensively exist in the body.Some researches of ophthalmology showed that RNAi can be used to prevent and treat multiple eye diseases,including ocular neovascularization,anti-fibrosis,intraocular tumors,autoimmune uveoretinitis,etc.RNAi plays role in switching on and off the target gene.Because RNAi can inhibit gene expression specifically and efficiently,it has gained increasing attention in recent years.The basic concept,acting mechanics and character of RNAi and its application in ophthalmology were summarized.
