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Zhonghua Zhong Liu Za Zhi ; 9(5): 328-32, 1987 Sep.
Article in Chinese | MEDLINE | ID: mdl-3330707

ABSTRACT

Possible antimutation of 108 preparations of 91 kinds of vegetables and fruits on Salmonella typhimurium TA98 and TA100 mutants was tested. 4-nitroquinoline-N-oxide (4 NQO), N-methyl-N-nitro-N-nitrosoguanidine (MNNG), aflatoxin B1 (AFB1) and benzo (a) pyrene (BaP) were used as mutagens. The results showed that 67 (62%) preparations had antimutagenic action in vitro to different degrees. 9.6% of all preparations showed inhibition action on 4 NQO in TA100 mutant and 12.3%, in TA98, 5% on MNNG in TA100, 38% on AFB1 in TA100 and 45.1% in TA98, 28.9% on BaP in TA100. This experiment provides a scientific basis to the study of food resources as prevention of carcinogenesis.


Subject(s)
Fruit , Mutation , Vegetables , Animals , Male , Mutagenicity Tests/methods , Rats , Salmonella typhimurium/genetics
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