Subject(s)
Shock, Cardiogenic/diagnosis , Ventricular Dysfunction, Left/diagnosis , Aged , Chest Pain/etiology , Diagnosis, Differential , Electrocardiography , Heart-Assist Devices , Humans , Intra-Aortic Balloon Pumping , Male , Percutaneous Coronary Intervention/methods , Shock, Cardiogenic/complications , Shock, Cardiogenic/therapy , Ventricular Dysfunction, Left/complications , Ventricular Dysfunction, Left/therapy , Young AdultABSTRACT
We evaluated whether serum omentin levels are associated with coronary artery disease (CAD) and its severity among postmenopausal women. We enrolled 193 consecutive postmenopausal women who had undergone coronary angiography for suspected stable CAD. The study population was divided into 2 groups based on the results of coronary angiography (CAD group, n=110 and control group, n=83). Omentin 1 levels were measured and disease severity was assessed using the SYNTAX score (SS) in the CAD group. Those patients with angiographic CAD had significantly decreased omentin 1 levels, compared to those without CAD (247.5+127.4 vs 506+246 ng/mL, P<.001). After adjusting for cardiovascular risk factors, a decreased omentin 1 level was found to be an independent predictor of both angiographic CAD and a high SS. Our data indicate that a decreased omentin 1 level is associated with CAD and its severity among postmenopausal women.
Subject(s)
Coronary Artery Disease/blood , Cytokines/blood , Lectins/blood , Postmenopause/blood , Aged , Biomarkers/blood , Case-Control Studies , Coronary Artery Disease/diagnostic imaging , Female , GPI-Linked Proteins/blood , Humans , Predictive Value of Tests , Radiography , Risk Factors , Severity of Illness IndexABSTRACT
PURPOSE: Modified TEI index is pointed to be more effective in the evaluation of global cardiac functions compared to systolic and diastolic measurements alone. We planned to determine its applicability in hypertension and relation with left ventricular mass index (LVMI). METHODS: We studied 48 patients with mild/moderate hypertension and normal coronary angiograms. In total 22 patients (12 men, 10 women, mean age: 55 +/- 6) with normal LVMI were studied in group I, 26 patients (12 men, 14 women, mean age: 57 +/- 7) with increased LVMI in group II, and 20 patients (10 men, 10 women, mean age: 53 +/- 7) with normal blood pressure as a control group. Standard 2D, Doppler, and mitral annulus pulse wave tissue Doppler were used for all measurements. Modified TEI index was calculated as diastolic time interval measured from end of Am wave to origin of Em (a') minus systolic Sm duration (b') divided by b(a'-b'/b'). RESULTS: Modified TEI index was significantly higher in both groups than normal group and in group II than in group I. ( CONTROL GROUP: 0.33 +/- 0.05, group I: 0.51 +/- 0.17, group II: 0.68 +/- 0.16, P< 0.0001). CONCLUSION: Modified TEI index, a marker of left ventricular systolic and diastolic functions, is impaired in hypertensives before hypertrophy develops and impairment is more prominent in hypertrophy. Therefore, (1) modified TEI index in hypertensives is a safe, feasible, and sensitive index for evaluation of global ventricular functions. (2) Evaluation of hypertensives with this index periodically may guide interventions directed toward saving systolic and diastolic functions. (3) Modified TEI index is gaining importance as a complementary parameter to standard Doppler or in cases where standard Doppler has its limitations.
