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World J Gastroenterol ; 14(23): 3633-41, 2008 Jun 21.
Article in English | MEDLINE | ID: mdl-18595130

ABSTRACT

AIM: To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia. METHODS: Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF-I), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones, body mass index (BMI) loss ratio, age, gender, and Glasgow Prognostic Score (GPS) were investigated. RESULTS: Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients (P < 0.05). Ghrelin, resistin, leptin, adiponectin and IGF-I, showed a significant correlation with BMI loss ratio and GPS (P < 0.05). A strong correlation was seen between GPS and BMI loss (R = -0.570, P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin, resistin, leptin and IGF-I (P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION: These results showed that serum ghrelin, leptin, adiponectin, and IGF-I play important roles in cachexia-related gastric cancers. No relationship was found between resistin and cancer cachexia. Also, because of the correlation between these parameters and GPS, these parameters might be used as a predictor factor.


Subject(s)
Adipokines/blood , Cachexia/metabolism , Ghrelin/blood , Stomach Neoplasms/complications , Adiponectin/blood , Adult , Aged , Blood Glucose/metabolism , Body Mass Index , C-Reactive Protein/metabolism , Cachexia/etiology , Cachexia/pathology , Case-Control Studies , Female , Humans , Insulin/blood , Insulin-Like Growth Factor I/metabolism , Leptin/blood , Male , Middle Aged , Multivariate Analysis , Neoplasm Staging , Prealbumin/metabolism , Prospective Studies , Resistin/blood , Serum Albumin/metabolism , Severity of Illness Index , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathology , Time Factors
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