The longitudinal relationship between loneliness and both social anxiety and mobile phone addiction among rural left-behind children: A cross-lagged panel analysis.

INTRODUCTION: Left-behind children are a special group that needs urgent attention. Due to enduring separation from their parents, loneliness is considered the most common and prevalent developmental hurdle in the experiences of left-behind children. This longitudinal cross-lagged study examined the direction of the association between loneliness and both internalizing and externalizing symptoms, with considering gender and left-behind status differences. METHODS: A total of 1175 rural Chinese children (48.3% boys, 39.9% left-behind children, Mage = 14.54 ± 1.18 at baseline) completed self-reported loneliness, social anxiety, and mobile phone addiction at two-time points with 6 months intervals. Descriptive statistics, cross-lagged panel analysis, and multiple group analysis were estimated in the present study. RESULTS: Loneliness exacerbated social anxiety and mobile phone addiction, and vice versa. In addition, gender and left-behind status moderated these relationships, with boys more likely to be mobile phone addicted due to loneliness and girls more likely to be lonely due to mobile phone addiction. More importantly, left-behind children with loneliness are more prone to social anxiety and mobile phone addiction, and vice versa, compared with non-left-behind children. CONCLUSIONS: The targeted interventions should be carried out for different genders and left-behind statuses. Particularly for left-behind children, neglecting to address both the symptoms of loneliness and both social anxiety and mobile phone addiction could significantly undermine the efficacy of intervention programs that solely target either one of these afflictions.

Alcohol use disorder and time perception: The mediating role of attention and working memory.

Alcohol use disorder (AUD) has been associated with attentional deficits and impairments of working memory. Meanwhile, attention and working memory are critical for time perception. However, it remains unclear how time perception alters in AUD patients and how attention and working memory affect their time perception. The current study aims to clarify the time perception characteristics of AUD patients and the cognitive mechanisms underlying their time perception dysfunction. Thirty-one patients (three of them were excluded) with AUD and thirty-one matched controls completed the Time Bisection Task, Attention Network Test and Digital Span Backward Test to assess their abilities in time perception, attention network and working memory, respectively. The results showed that, after controlling for anxiety, depression, and impulsivity, AUD patients had a lower proportion of 'long' responses at intervals of 600, 750, 900, 1050 and 1200 ms. Furthermore, they displayed higher subjective equivalence points and higher Weber ratios compared to controls. Moreover, AUD patients showed impaired alerting and executive control networks as well as reduced working memory resources. Only working memory resources mediated the impact of AUD on time perception. In conclusion, our findings suggested that the duration underestimation in AUD patients is predominantly caused by working memory deficits.

The Relationship Between Parenting Stress and Parental Burnout Among Chinese Parents of Children with ASD: A Moderated Mediation Model.

This study investigated the role of resilience as a mediator and the place of residence as a moderator of parenting stress and parental burnout. The Parenting Stress Index-Short Form, Parental Burnout Assessment, and Connor-Davidson Resilience Scale were administered to 249 Chinese parents of children with ASD (M = 33.95 years, SD = 7.6). Results show that resilience partially mediates the relation between parenting stress and parental burnout. Besides, both the effect of parenting stress on parental burnout and the mediating effect of resilience are moderated by rural/urban residence. This study highlights parenting stress is a risk factor for parental burnout and resilience is the potential mechanism underlying this relation. These findings provide implications for family services for parents of children with ASD.

Neural basis underlying the relation between internet addiction tendency and sleep quality: The intrinsic default-mode network connectivity pathways.

Internet addiction (IA) tendency is considered an addictive behavior that results from excessive Internet use, and severely affecting an individual's physical health, emotion, and sleep. Although previous studies indicated that IA tendency was negatively correlated with sleep quality, the underlying neural basis of this relationship remained unclear. To address this issue, we utilized resting-state functional connectivity (RSFC) analysis to identify the neural pathways of the relationship between IA tendency and sleep quality. The behavioral results indicated a positive correlation between these two factors. And RSFC results revealed that IA tendency was positively related to the strength of functional connectivity within the default-mode network (DMN), including the right precuneus-left middle temporal gyrus (rPrcu-lMTG), the left anterior cingulate-left superior frontal gyrus (lAC-lSFG), and the left inferior parietal lobe-left medial superior frontal gyrus (lIPL-lMSFG). More importantly, mediation analysis demonstrated that IA tendency could mediate the relationship between these functional couplings and sleep quality. In conclusion, our findings suggest that intrinsic DMN connectivity may be an important neural pathways underlying the effects of IA tendency on sleep quality, and provide neural evidence for understanding the relationship between IA tendency and sleep quality.

Different emotion regulation strategies mediate the relations of corresponding connections within the default-mode network to sleep quality.

Despite a long history of interest in the relation of emotion regulation to sleep quality, how different strategies link with sleep quality at the neural level is still poorly understood. Thus, we utilized the process model of emotion regulation as an organizing framework for examining the neurological underpinning of the links between the two emotion regulation strategies and sleep quality. 183 young adults (51.7% females, Mage = 22.16) were guided to undergo the MRI scans and then complete the Pittsburgh Sleep Quality Index (PSQI) and the emotion regulation Questionnaire (ERQ) formed by two dimensions: cognitive reappraisal and expressive suppression. Results found that emotion regulation mediated the association between functional connectivity within the intrinsic default-mode network (DMN) and sleep quality. Specifically, rsFC analysis showed that cognitive reappraisal was positively correlated with rsFC within DMN, including left superior temporal gyrus (lSTG)-left lateral occipital cortex (lLOC), lSTG-left anterior cingulate gyrus (lACG), right lateral occipital cortex (rLOC)-left middle frontal gyrus (lMFG), and rLOC-lSTG. Further mediation analysis indicated a mediated role of cognitive reappraisal in the links between the four connectivity within the DMN and sleep quality. In addition, expressive suppression was positively correlated with rsFC within DMN, including left precuneus cortex (lPrcu)-right Temporal Pole (rTP) and lPrcu- lSTG. Further mediation analysis indicated a mediated role of expressive suppression in the links between the two connectivity within the DMN and sleep quality. Overall, this finding supports the process model of emotion regulation in that the effects of reappraisal and suppression have varying neural circuits that impact that strategy's effect on sleep quality.

How Trait Gratitude Influences Adolescent Subjective Well-Being? Parallel-Serial Mediating Effects of Meaning in Life and Self-Control.

The relationship between trait gratitude and subjective well-being is well documented in the literature. Recently, growing attention has been given to examining which factors are determinants in the relationship. However, there are no studies to present a comprehensive model of how meaning in life and self-control jointly play a role in this relationship. This study investigated parallel and serial mediation of the presence of meaning, the search for meaning, and self-control in the relationship between trait gratitude and subjective well-being. A total of 764 adolescents (Mage = 14.10, SD = 1.43, 48.43% males) from three middle schools in China completed a six-item measures of gratitude questionnaire form, a meaning in life questionnaire, a middle school students' self-control ability questionnaire, and a satisfaction with life scale. The study revealed that trait gratitude affected the presence of meaning and subsequently affected subjective well-being. In addition, trait gratitude affected self-control through the presence of meaning and the search for meaning, and it subsequently affected subjective well-being. Therefore, the presence of meaning, the search for meaning, and self-control played an important role in the positive effects of trait gratitude on adolescent subjective well-being. The findings were in line with the intrinsic and extrinsic goal theory of gratitude and provided new insight to inform the improvement of adolescent subjective well-being in the future.

The Prevalence and Severity of School Bullying among Left-Behind Children: A Meta-Analysis.

The involvement of left-behind children (LBC) in school bullying has raised concern in China. However, the susceptibility of LBC to engage in bullying is controversial, and comprehensive, representative studies covering the entire country are lacking. The purpose of this study was to evaluate the prevalence and severity of school bullying among LBC. The Chinese National Knowledge Network, WanFang, VIP, PubMed, Web of Science, EMBASE, and EBSCO databases were searched for literature on being left-behind and bullying before April 2022. The effect size was measured by odds ratio (ORs), standard mean difference (SMD), and 95% confidence interval (CI). Random-effects or fixed-effects models were selected for meta-analysis, and subgroup analysis was used to explore the sources of heterogeneity. The meta-analysis included 25 studies of school bullying among LBC and non-LBC (NLBC). The prevalence of bullying perpetration and victimization among LBC were 18.58% (95% CI [3.72%, 33.44%], p < .05) and 40.62% (95% CI [25.47%, 55.78%], p < .05), respectively. Compared with NLBC, the risk of bullying perpetration and victimization among LBC increased 1.97 times (OR = 1.97, 95% CI [1.77, 2.20], p < .05) and 2.17 times (OR = 2.17, 95% CI [1.43, 3.29], p < .05), respectively. The severity of bullying experienced by LBC was higher than that of NLBC (SMD = 0.49, 95% CI [0.20, 0.79], p < .05). The prevalence and severity of school bullying were higher in LBC than in NLBC, and left-behindness was positively associated with school bullying. LBC are a crucial population to protect when developing bullying interventions.

The impact of peer victimization on Chinese left-behind adolescent suicidal ideation: The mediating role of psychological suzhi and the moderating role of family cohesion.

BACKGROUND: The detrimental impact of peer victimization on suicidal thoughts has been tested in numerous previous studies, but the underlying mechanisms tying the two together remain unclear, particularly for left-behind adolescents in China, who are defined as the adolescent staying behind in rural areas for a duration exceeding six months while having one or both parents relocate to urban areas for employment purposes. OBJECTIVE: This study intends to investigate the relationship between peer victimization and suicidal ideation in Chinese left-behind adolescents and the mediating effect of psychological suzhi (a comprehensive positive quality that related to developmental, adaptive, and creative behaviors) and the moderating role of family cohesion. PARTICIPANTS AND SETTINGS: A total of 417 Chinese left-behind adolescents (Mage at Time 1 = 14.84 ± 1.08 years; 57.55 % male) were recruited for the study. Participants came from rural counties of central China in Hunan province which has suffered a large labor migration. METHODS: We conducted a two-wave longitudinal study with six-month intervals. Participants completed the measures of the Chinese peer victimization scale for children and adolescents, the adolescent's psychological suzhi questionnaire, the self-rating idea of suicide scale, and the cohesion dimension of the family adaptability cohesion scale. RESULTS: Path modeling results indicated that psychological suzhi partially mediated the link between peer victimization and suicidal ideation. Family cohesion moderated the association between peer victimization and suicidal ideation. The link between peer victimization and suicidal ideation was weaker for left-behind adolescents with higher family cohesion. CONCLUSION: Peer victimization was found to diminish psychological suzhi, which in turn increases the risk of suicidal ideation. However, family cohesion buffered the negative effect of peer victimization on suicidal ideation, suggesting that left-behind adolescents with greater family cohesion may be better equipped to prevent suicidal ideation, which has implications for future family and school education and provides some ideas and a foundation for future research.

Early Emotional Experiences and Prosocial Behavior among Chinese Adolescents: The Roles of Psychological Suzhi and Subjective Socioeconomic Status.

Prosocial behavior plays a vital role in adolescents' well-being and social functioning, with the recall of early emotional experiences being a major influence. Positive experiences such as early memories of warmth and safeness (EMWS) contribute to prosocial interpersonal characteristics, whereas adverse experiences such as child psychological abuse and neglect (CPAN) lead to social withdrawal or behavioral problems. The direct effects of EMWS and CPAN on prosocial behavior were investigated in this study, along with the mediation effect of psychological suzhi and the moderation effect of subjective socioeconomic status (SSS). A sample of 948 adolescents (Mage = 14.05 years, SD = 1.68 years; 43.6% females) was randomly recruited to complete self-report questionnaires. Correlation results indicated that EMWS promoted prosocial behavior, whereas CPAN was negatively associated with prosocial behavior. Path analyses confirmed the mediating role of psychological suzhi on the effects of EMWS and CPAN on prosocial behavior. SSS was shown to moderate the effects of EMWS on prosocial behavior and CPAN on psychological suzhi. Compared to lower SSS, higher SSS would reinforce the positive impact of EMWS on prosocial behavior and exacerbate the negative impact of CPAN on psychological suzhi. The current study provided new insight into understanding the underlying mechanisms of prosocial behavior from the perspective of early emotional experiences.

Toward Robust Fault Identification of Complex Industrial Processes Using Stacked Sparse-Denoising Autoencoder With Softmax Classifier.

This article proposes a robust end-to-end deep learning-induced fault recognition scheme by stacking multiple sparse-denoising autoencoders with a Softmax classifier, called stacked spare-denoising autoencoder (SSDAE)-Softmax, for the fault identification of complex industrial processes (CIPs). Specifically, sparse denoising autoencoder (SDAE) is established by integrating a sparse AE (SAE) with a denoising AE (DAE) for the low-dimensional but intrinsic feature representation of the CIP monitoring data (CIPMD) with possible noise contamination. SSDAE-Softmax is established by stacking multiple SDAEs with a layerwise pretraining procedure, and a Softmax classifier with a global fine-tuning strategy. Furthermore, SSDAE-Softmax hyperparameters are optimized by a relatively new global optimization algorithm, referred to as the state transition algorithm (STA). Benefiting from the deep learning-based feature representation scheme with the STA-based hyperparameter optimization, the underlying intrinsic characteristics of CIPMD can be learned automatically and adaptively for accurate fault identification. A numeric simulation system, the benchmark Tennessee Eastman process (TEP), and a real industrial process, that is, the continuous casting process (CCP) from a top steel plant of China, are used to validate the performance of the proposed method. Experimental results show that the proposed SSDAE-Softmax model can effectively identify various process faults, and has stronger robustness and adaptability against the noise interference in CIPMD for the process monitoring of CIPs.

The role of valence, arousal, stimulus type, and temporal paradigm in the effect of emotion on time perception: A meta-analysis.

Anecdotal experiences show that the human perception of time is subjective, and changes with one's emotional state. Over the past 25 years, increasing empirical evidence has demonstrated that emotions distort time perception and usually result in overestimation. Yet, some inconsistencies deserve clarification. Specifically, it remains controversial how valence (positive/negative), arousal (high/low), stimulus type (scenic picture/facial expression/word/sound), and temporal paradigm (reproduction/estimation/discrimination) modulate the effect of emotion on time perception. Thus, the current study aimed to conduct a meta-analysis to quantify evidence for these moderators. After searching the Web of Science, SpiScholar, and Google Scholar, 95 effect sizes from 31 empirical studies were calculated using Hedges'g. The included studies involved 3,776 participants. The results a highlighted significant moderating effect of valence, arousal, stimulus type, and temporal paradigm. Specifically, negative valence tends to result in overestimation relative to positive valence; the increasing arousal leads to increasing temporal dilating; scenic picture, facial picture, and sound are more effective in inducing distortions than word; the overestimation can be better observed by discrimination and estimation paradigms relative to reproduction paradigms, and estimation paradigm is likely to be the most effective. These results suggest that the effect of emotion on time perception is influenced by valence, arousal, stimulus type, and temporal paradigm. These mitigating factors should be considered by scientists when studying time perception.

Psychological resilience mediates the association of the middle frontal gyrus functional connectivity with sleep quality.

Psychological resilience is characterized as the ability to recover from stress, which is essential for sleep quality. However, the neurological underpinnings of psychological resilience and the neural substrates of the links between psychological resilience and sleep quality in healthy brains remain not well understood. To address these issues, we adopted the method of resting-state functional connectivity (rs-FC) analysis in 144 young college students. The functional connectivity analysis indicated that psychological resilience was associated with the middle frontal gryus (MFG) functional connectivity, which mainly involved the right middle cingulum gyrus (rMCG), the right precentral gyrus (rPreCG), the left postcentral gyrus (lPoCG), and the left thalamus. Furthermore, mediation analysis suggested that psychological resilience played a mediating role in the relationship between MFG functional connectivity and sleep quality. Overall, the current study offered further evidence for the neurological underpinnings of psychological resilience and provided new insights into the relationship between psychological resilience and sleep quality from a neural basis perspective.

Negative emotions and brain: Negative emotions mediates the association between structural and functional variations in emotional-related brain regions and sleep quality.

IMPORTANCE AND STUDY OBJECTIVE: Emotion plays an important role in sleep quality, meanwhile, poor sleep quality is usually correlated with high negative emotions (NES). However, less is known about the neural basis for NES and the underlying mechanism for how NES affect individuals' sleep quality in the health brain. The present study combined voxel-based morphometry and resting-state functional connectivity analysis to identify the relationship between brain regions and NES, and then explored how NES-related brain structures are related to sleep quality in a large sample of normal young adults. DESIGN AND PARTICIPANTS: The present study used a fMRI procedure. Participants were 339 normal young adults. The NES was represented by the principal components of four measures: the Self-rating Anxiety Scale, Self-rating Depression Scale, Negative Affect Schedule, and Psychosomatic Tension Relaxation Inventory. Sleep quality was measured using the Pittsburgh Sleep Quality Index. RESULTS: Results showed that higher NES scores were associated with larger regional gray matter volume (rGMV) in the left parahippocampal gyrus, right superior temporal gyrus, and right postcentral gyrus. Further functional connectivity analysis demonstrated that the connectivity between these three brain regions and a specific set of emotion-related regions was also significantly associated with NES scores. Moreover, NES acted as a mediator of the relationship between the rGMV of the left parahippocampal gyrus, right superior temporal gyrus, and right postcentral gyrus and sleep quality. NES also mediated the relationship between the connectivity between the right superior temporal-supplementary motor area and the right superior temporal-right precentral gyrus and sleep quality. CONCLUSION: The present study provides the further evidence for neural substrates of NES and reveals a potential mechanism that NES mediates the effect of spontaneous brain activity on sleep quality. Meanwhile, these findings indicate that negative emotions share a common brain structure and function based on sleep quality.

Resting-state functional connectivity of the sensory/somatomotor network associated with sleep quality: evidence from 202 young male samples.

Previous neuroimaging studies have demonstrated that sleep is associated with brain functional changes in some specific brain regions. However, few studies have examined the relationship between all possible functional connectivities (FCs) within the sensory/somatomotor network (SSN) and the sleep quality of young male samples. The SSN consists of two motor cortices and is known to play a critical role in sleep. Poor sleep quality may be associated with increased sensory/somatomotor functional connectivity during rest. Hence, 202 young male participants underwent a resting-state functional magnetic resonance imaging (fMRI) scan and completed the Pittsburgh Sleep Quality Index (PSQI). Results indicated that increased functional connectivity within the SSN was associated with poor sleep quality. Specifically, the total PSQI score was positively correlated with the increased functional connectivity of the left paracentral lobule (PCL), bilateral precentral gyrus (PreCG), supplementary motor area (SMA) and bilateral postcentral gyrus (PoCG). Additionally, our findings also exhibited that (a) the subjective sleep quality factor of PSQI was positively correlated with FC between the bilateral PoCG and the bilateral PCL as well as between the left PreCG and the right SMA; (b) the sleep latency factor of PSQI was positively correlated with FC between the left PoCG and the right precuneus (PCUN); (c) the sleep disturbances factor of PSQI was positively correlated with FC between the left PCL and the right PoCG, and (d) the daytime dysfunction factor of PSQI was positively correlated with FC between the bilateral PoCG and the left PCL as well as between the bilateral PreCG and the SMA. In short, our findings can be comprehensively understood as neural mechanisms of intrinsic SSN connectivity are associated with sleep quality of man. Meanwhile, it may expand our knowledge and provide new insight into a deeper understanding of the neurobiological mechanisms of sleep or sleep problems.

Bullying victimization and suicidal ideation among adolescents: The mediating role of psychological suzhi and the moderating role of perceived school climate.

This study explores the association between bullying victimization and suicidal ideation and determines the mediating role of psychological suzhi and the moderating role of perceived school climate. 855 (Nboy = 417, Ngirl = 438; Mage=13.18, SD = .78) students in this study from grade 7 to grade 9 completed questionnaires of the mentioned study variables. The results indicated that bullying victimization positively predicted adolescents' suicidal ideation. Psychological suzhi partially mediated the effect of bullying victimization on suicidal ideation. However, for adolescents with higher levels of perceived school climate, bullying victimization was correlated more strongly with suicidal ideation and weaker with psychological suzhi. Results meant that the more frequent and more severe the bullying, the higher the likelihood of suicidal ideation among adolescents. Psychological suzhi may act as a potential mechanism through which bullying victimization leads to suicidal ideation, nevertheless, perceived school climate not only buffered bullying victimization's effects on suicidal ideation, but also protected psychological suzhi from the negative influence of bullying.

Association of white matter volume with sleep quality: a voxel-based morphometry study.

Many studies have focused on the gray matter volume associated with sleep quality, little is known about the relationship between white matter volume and sleep quality. Brain white structure is a crucial component in the structural neuroanatomy. Therefore, in this study, we investigated the association between white matter volume and sleep quality. Data were collected using the Pittsburgh Sleep Quality Index and voxel-based morphometry among 352 college students. Results showed that the global PSQI score was negatively associated with the white matter volume, including in the right middle occipital gyrus, the left superior temporal gyrus, the right the precentral gyrus, the left supramarginal gyrus, the left middle frontal gyrus, the left precunes, and the right superior frontal gyrus. Results also indicated that the white matter volume in specific regions negatively associated with the factor of PSQI. These specific brain regions may be replicated in brain areas related to sleep quality. In summary, we suggested that exploring brain white structure are related to sleep could help to expound the mechanisms by which sleep quality are associated with brain function, behavior and cognition, as well as potentially the networks and systems responsible for variations in sleep themselves.

The gray matter volume of bilateral inferior temporal gyrus in mediating the association between psychological stress and sleep quality among Chinese college students.

The role of brain regions in the relationship between psychological stress and sleep quality is unclear. This study investigates the neuroanatomical basis of the association between psychological stress and sleep quality. Data were collected using the Pittsburgh Sleep Quality Index, the Psychosomatic Tension Relaxation Inventory, and voxel-based morphometry among 318 healthy students. The results showed that psychological stress was negatively correlated with sleep quality. According to the mediation analysis results, the correlation between psychological stress and sleep quality was partially mediated by the region of the bilateral inferior temporal gyrus. These findings suggest that there is a strong link between sleep quality and psychological stress, highlighting the gray matter volume of the bilateral inferior temporal gyrus related to emotional processing, which plays an essential role in improving sleep quality.

The Effects of Angry Expressions and Fearful Expressions on Duration Perception: An ERP Study.

Little is known about the electrophysiological basis of the effect of threat-related emotional stimuli with different motivational direction on duration perception. Thus, event-related potentials were employed to examine the effects of angry expressions and fearful expressions on perception of different duration (490-910 ms). Behavioral results showed there was a greater underestimation of the duration of angry expressions (approach-motivated negative stimuli) than fearful expressions (withdrawal-motivated negative stimuli), compared with neutral expressions. Event-related potentials results showed that, the area of Contingent Negative Variation (CNV) evoked by angry expression, fearful expression and neutral expression gradually increased. These results indicated that specific electrophysiological mechanisms may underlie the attention effects of angry and fearful expressions on timing. Specifically, compared with neutral expressions, fearful expressions and angry expressions both are likely to distract more attentional resources from timer, in particular, angry expressions attract more attention resources than fearful expressions from timer. The major contribution of the current study is to provide electrophysiological evidences of fear vs. anger divergence in the aspect of time perception and to demonstrate beyond the behavioral level that the categorization of threat-related emotions should be refined so to highlight the adaptability of the human defense system.

Automated cardiac segmentation of cross-modal medical images using unsupervised multi-domain adaptation and spatial neural attention structure.

Accurate cardiac segmentation of multimodal images, e.g., magnetic resonance (MR), computed tomography (CT) images, plays a pivot role in auxiliary diagnoses, treatments and postoperative assessments of cardiovascular diseases. However, training a well-behaved segmentation model for the cross-modal cardiac image analysis is challenging, due to their diverse appearances/distributions from different devices and acquisition conditions. For instance, a well-trained segmentation model based on the source domain of MR images is often failed in the segmentation of CT images. In this work, a cross-modal images-oriented cardiac segmentation scheme is proposed using a symmetric full convolutional neural network (SFCNN) with the unsupervised multi-domain adaptation (UMDA) and a spatial neural attention (SNA) structure, termed UMDA-SNA-SFCNN, having the merits of without the requirement of any annotation on the test domain. Specifically, UMDA-SNA-SFCNN incorporates SNA to the classic adversarial domain adaptation network to highlight the relevant regions, while restraining the irrelevant areas in the cross-modal images, so as to suppress the negative transfer in the process of unsupervised domain adaptation. In addition, the multi-layer feature discriminators and a predictive segmentation-mask discriminator are established to connect the multi-layer features and segmentation mask of the backbone network, SFCNN, to realize the fine-grained alignment of unsupervised cross-modal feature domains. Extensive confirmative and comparative experiments on the benchmark Multi-Modality Whole Heart Challenge dataset show that the proposed model is superior to the state-of-the-art cross-modal segmentation methods.

The gray matter volume of the right insula mediates the relationship between symptoms of depression/anxiety and sleep quality among college students.

This study investigated the neuroanatomical basis of the association between depression/anxiety and sleep quality among 370 college students. The results showed that there was a significant correlation between sleep quality and depression/anxiety. Moreover, mediation results showed that the gray matter volume of the right insula mediated the relationship between depression/anxiety and sleep quality, which suggested that depression/anxiety may affect sleep quality through the right insula volume. These findings confirmed a strong link between sleep quality and depression/anxiety, while highlighting the volumetric variation in the right insula associated with emotional processing, which may play a critical role in improving sleep quality.