1.
Bioorg Med Chem Lett
; 14(11): 2829-33, 2004 Jun 07.
Article
in English
| MEDLINE
| ID: mdl-15125941
ABSTRACT
In our investigations to synthesize inhibitors of smooth muscle cell (SMC) proliferation, compound 6a displayed submicromolar activity in in vitro antiproliferative assays and reduced intimal thickening using a rat balloon angioplasty model via i.v. administration. In order to identify analogs that could be administered orally, the chemical instability of the C-4',6' acetal of compound 6a was addressed. Several novel variants with increased acid stability and comparable in vitro activity were prepared.