ABSTRACT
Noninvasive and real-time optical detection of cardiac hemodynamics dysfunction during myocardial ischemia remains challenging. In this study, we developed a near-infrared spectroscopy device to monitor rats' myocardial hemodynamics. The well-designed system can accurately reflect the hemodynamics changes by the classic upper limb ischemia test. Systemic hypoxia by disconnecting to the ventilator and cardiac ischemia by coronary artery slipknot ligation was conducted to monitor myocardial hemodynamics. When systemic hypoxia occurred, ΔHbR and ΔtHb increased significantly, whereas ΔHbO decreased rapidly. When coronary blood flow was obstructed by slipknots, cardiothoracic ΔHbO immediately begins to decline, while ΔHbR also significantly increases. Simultaneously, SpO2 did not show any obvious changes during myocardial ischemia, while SpO2 decreased significantly during systemic hypoxia. These results demonstrated that cardiothoracic hemodynamics stemmed from myocardial ischemia. This pilot study demonstrated the practicality of noninvasive, low-cost optical monitoring for cardiac oxygenation dysfunction in rats.
ABSTRACT
Surface urban heat islands (SUHIs) are mostly an urban ecological issue. There is a growing demand for the quantification of the SUHI effect, and for its optimization to mitigate the increasing possible hazards caused by SUHI. Satellite-derived land surface temperature (LST) is an important indicator for quantifying SUHIs with frequent coverage. Current LST data with high spatiotemporal resolution is still lacking due to no single satellite sensor that can resolve the trade-off between spatial and temporal resolutions and this greatly limits its applications. To address this issue, we propose a multiscale geographically weighted regression (MGWR) coupling the comprehensive, flexible, spatiotemporal data fusion (CFSDAF) method to generate a high-spatiotemporal-resolution LST dataset. We then analyzed the SUHI intensity (SUHII) in Chengdu City, a typical cloudy and rainy city in China, from 2002 to 2022. Finally, we selected thirteen potential driving factors of SUHIs and analyzed the relation between these thirteen influential drivers and SUHIIs. Results show that: (1) an MGWR outperforms classic methods for downscaling LST, namely geographically weighted regression (GWR) and thermal image sharpening (TsHARP); (2) compared to classic spatiotemporal fusion methods, our method produces more accurate predicted LST images (R2, RMSE, AAD values were in the range of 0.8103 to 0.9476, 1.0601 to 1.4974, 0.8455 to 1.3380); (3) the average summer daytime SUHII increased form 2.08 °C (suburban area as 50% of the urban area) and 2.32 °C (suburban area as 100% of the urban area) in 2002 to 4.93 °C and 5.07 °C, respectively, in 2022 over Chengdu City; and (4) the anthropogenic activity drivers have a higher relative influence on SUHII than other drivers. Therefore, anthropogenic activity driving factors should be considered with CO2 emissions and land use changes for urban planning to mitigate the SUHI effect.
ABSTRACT
Glioma is the most common and aggressive primary intracranial tumor within the central nervous system. The blood-brain barrier (BBB) has been a great hurdle for an effective glioma treatment. To effectively treat glioma, various strategies have been applied to deliver drugs to the brain by crossing the BBB. Nanocarrier-mediated drug delivery is emerging as an effective and noninvasive system to treat glioma, showing great potential in glioma therapy. In this review, we will provide a comprehensive overview on nanocarrier-mediated drug delivery and related glioma therapy. Following an initial overview of the BBB and blood-brain-tumor barrier (BBTB) structure and characteristics, nanocarrier-mediated drug delivery strategies (liposomes, micelles, inorganic systems, polymeric nanoparticles, nanogel system, biomimetic nanoparticles, and exosomes) for crossing the BBB are discussed. Finally, nanotherapeutic techniques (imaging-mediated chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, immunotherapy, ferroptosis therapy, sonodynamic therapy, chemodynamic therapy, and combination therapy) in treating glioma are summarized. In addition, this review provides some perspectives on the clinical applications of nanomedicines.
