Modeling and assessing the impacts of climate change on groundwater recharge in endorheic basins of Northwest China.

Climate change imposing additional stressors on groundwater resources globally, thereby predicting groundwater recharge (GR) changes is crucial to sustainably managing water resources, especially in the arid endorheic basins. Groundwater in the Endorheic Basins of Northwest China (NWEB) is potentially impacting regional socio-economic output and ecosystem stability due to the imbalance between supply and extraction exacerbated by climate change. Hence, recognizing the impacts of climate change on past and future GR is imperative for groundwater supply and sustainable groundwater management in the NWEB. Here, the impact of historical (1971-2020) and projected (2021-2100) climate changes on GR across the entire NWEB and three distinctive landscape regions (i.e., mountainous, oasis, and desert) were assessed. A coupled distributed hydrologic model (CWatM-HBV model), which integrates the Community Water Model (CWatM) and the HBV model, was run with three shared socioeconomic pathways (SSP1-2.6, SSP2-4.5, and SSP3-7.0) forcing from 10 general circulation models (GCMs) to simulate and analyze the interannual and seasonal variations of GR, along with their driving factors. Over the past 50 years, both precipitation and runoff have undergone significant increases, and leading to a dramatic rise in GR (0.09 mm yr-1). The future annual growth rate of GR is projected to range from 0.01 to 0.09 mm yr-1 from SSP1-2.6 to SSP3-7.0 across the entire NWEB, with the majority of the increase expected during the spring and summer seasons, driven by enhanced precipitation. GR from the mountainous region is the primary source (accounting for approximately 56-59 %) throughout the NWEB with the greatest increase anticipated. Precipitation and runoff have significant influences on GR in mountainous areas, and the impact of precipitation on GR is expected to increase over time. Changes in GR in oasis and desert areas are mainly limited by precipitation variation and increase in the SSP2-4.5 and SSP3-7.0 scenario. Additionally, the processes of glacial retreat and permafrost degradation will complicate the GR dynamics although the process is largely interfered with by anthropogenic environmental changes, especially in oasis-desert systems. The average annual recharge in the NWEB was 8.9 mm in the historical period and 13.6 ± 4.1 mm in the future. Despite an increase in GR due to climate change, groundwater storage is likely to continue to decline due to complex water demands in the NWEB. This study highlights the significance of future precipitation changes for GR and contributes to the understanding of the influence of climate change on groundwater systems and advances the sustainable management of water resources.

Activation of SIRT1 by hyperbaric oxygenation promotes recovery of motor dysfunction in spinal cord injury rats.

BACKGROUND: Hyperbaric oxygenation (HBO) therapy can improve locomotor dysfunction following spinal cord injury (SCI). Emerging evidence has demonstrated that sirtuin1 (SIRT1) exerts protective effects on neurons. However, whether HBO alleviates locomotor dysfunction by regulating SIRT1 is unclear. METHODS: The traumatic SCI animal model was performed on the adult Sprague-Dawley rats. The Basso, Beattie Bresnahan (BBB) locomotor rating scale was used to evaluate the open-field locomotor function. Western blot, real-time quantitative reverse transcription polymerase chain reaction, SIRT1 activity assay, and enzyme-linked immunosorbent assays were performed to explore the molecular mechanisms. RESULTS: We found that series HBO therapy significantly improved locomotor dysfunction and ameliorated the decreased mRNA, protein, and activity of spinal cord SIRT1 induced by traumatic SCI injury in rats. In addition, intraperitoneal injection of SIRT1 inhibitor EX-527 abolished the beneficial effects of series HBO treatment on locomotor deficits. Importantly, series HBO treatment following the traumatic SCI injury inhibited the inflammatory cascade and apoptosis-related protein, which was retained by EX-527 and enhanced by SRT1720. Furthermore, EX-527 blocked the enhanced induction of autophagy series with the HBO application. CONCLUSION: These findings demonstrated a new mechanism for series HBO therapy involving activation of SIRT1 and subsequent modulation of the inflammatory cascade, apoptosis, and autophagy, which contributed to the recovery of motor dysfunction.

Spatiotemporal variability and controlling factors of groundwater depletion in endorheic basins of Northwest China.

Recent global groundwater overpumping is threatening ecosystem stability and food security, particularly in arid basins. A solid investigation regarding the drivers of groundwater depletion is vital for groundwater restoration, hitherto, yet it remains largely unquantified. Here, a framework to quantify the contribution of natural forcing (NF) and anthropogenic perturbations (AP) to groundwater storage anomalies (GWSA) variability by separating the GWSA estimated by the Gravity Recovery and Climate Experiment (GRACE) satellite into natural- and human-induced GWSA was proposed in the northwest endorheic basin (NWEB) of China. Further, a multiple linear regression model was established for GWSA change prediction. Our results showed that, during the period 2003-2020, the GWSA depleted at a rate of 0.25 cm yr-1 in the entire NWEB. In addition, GWSA was found to decrease significantly (exceeding 1 cm yr-1) in the west of NWEB where there are heavily irrigated areas, and has become one of the regions with the most serious groundwater depletion in China. Whereas a significantly increasing trend (greater than 0.5 cm yr-1) was observed in the Qaidam basin and south part of the Tarim River basin, becoming a groundwater enrichment reservoir in NWEB. The negative contribution of AP to groundwater depletion has increased from 3% to 95% in the last decade, as determined by separating the effects of NF and AP on GWSA. The rapid expansion of the cropland area and the increase in water use due to population growth are investigated to be the main reasons for GWSA depletion, particularly in the North Tianshan Rivers, Turpan-Hami, and Tarim River basins. Therefore, we conclude that AP are dominating and accelerating groundwater depletion in the NWEB. The increase of GWSA in the Qaidam basin has been attributed to the increase in solid water melt and regional precipitation. The western route project of China's south-north water diversion and water-saving irrigation are important ways to solve the problem of groundwater depletion in NWEB. Our results emphasize that a more feasible framework capable of reliably identifying the driving factors of groundwater storage change is a necessary tool for promoting the sustainable management of groundwater resources under both NF and AP in arid endorheic basins.

The role of land use change in affecting ecosystem services and the ecological security pattern of the Hexi Regions, Northwest China.

The land use and land cover change (LUCC) associated with climate change and human activities is supposed to exert a significant effect on ecosystem functions in arid inland regions. However, the role of LUCC in shaping the spatio-temporal patterns of ecosystem services and ecological security remain unclear, especially under different future LUCC scenarios. Here, we evaluated dynamic changes of ecosystem services and ecological security pattern (ESP) in the Hexi Regions based on LUCC and other environment variables by integrating morphological spatial pattern analysis (MSPA), entropy weight method and circuit theory. Our result showed that the LUCC was generally stable from 1980 to 2050. Compare to 2020, the land conversion under natural growth (NG), ecological protection (EP) and urban development (UD) scenarios in 2050 has changed by 10.30 %, 10.10 %, and 10.31 %, respectively. The forest, medium-cover grassland and water increased in the EP scenario, and construction land and cropland greatly expanded in the other two scenarios. Ecosystem services grew larger in the EP scenario by 2050 in comparison with the NG and UD scenarios. The ESP in the Hexi Regions has obvious spatial differences during 1980-2050. The larger ecological sources and less resistance corridors were mainly distributed in the central and eastern of the Hexi Regions with high ecosystem services. Conversely, fragmented ecological sources and larger resistance corridors were mostly located in the western regions blocked by sandy land, bare land or mountains. Compared to 2020, the area of ecological sources and pinch points under the EP scenario in 2050 increased by 4.10 × 103 km2 and 0.31 × 103 km2, respectively. The number of ecological corridors reduced while the length and resistance increased apart from the EP scenario. Our results highlighted the importance of ecological protection in shaping the LUCC, which further enhances the integrity of ecosystem and ecological security.

Acupoint application therapy for diarrhea-predominant irritable bowel syndrome: a protocol for systematic review and network meta-analysis.

BACKGROUND: Irritable bowel syndrome is a chronic functional gastrointestinal disease, of which diarrhea-predominant irritable bowel syndrome (IBS-D) is a common subtype. In China, acupoint application therapy is currently widely used as an effective complementary therapy for IBS-D. In the clinical management of IBS-D, acupoint application is usually combined with other therapies, including acupuncture, moxibustion, and Chinese herbal and Western medicine. However, at present, evidence regarding the most effective options for treating IBS-D is insufficient. Therefore, this protocol proposes a systematic review and network meta-analysis for evaluating the effectiveness of acupoint application and its combination therapies in treating IBS-D, and for identifying the acupoint application-related treatments with the highest probability of being the best intervention. METHODS: Six English electronic databases (PubMed, Ovid MEDLINE, Scopus, Web of Science, the Cochrane Library, and EMBASE), four Chinese electronic databases [China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (CQVIP), WanFang, and SinoMed), and one Japanese medical database (Citation Information by National Institute of Informatics (CiNii)] will be searched for eligible randomized controlled trials from their inception to June 1, 2022. The efficacy and safety of acupoint application therapy and its combination therapies for patients with IBS-D will be evaluated. The STATA 14.0 (StataCorp, USA) software package will be used for the meta-analysis. A Bayesian network meta-analysis (NMA) will be performed using R (version 4.0.2) and Aggregate Data Drug Information System (ADDIS, version 1.16.8) software packages. Bias risk will be assessed using the Cochrane Collaboration's risk of bias tool; specifically, publication bias will be evaluated using Egger's test and funnel plots. The rank probabilities of various outcomes for each intervention will be calculated, clustered, and ranked using the cumulative ranking curve method. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method will be employed to assess the certainty of evidence for NMA outcomes. CONCLUSIONS: This study will aim to determine the clinical efficacy of acupoint application therapy and its combined therapy in the treatment of IBS-D and provide an evidence-based foundation for identifying the best acupoint application program.

An interplay of soil salinization and groundwater degradation threatening coexistence of oasis-desert ecosystems.

In salt-affected and groundwater-fed oasis-desert systems, water and salt balance is critically important for stable coexistence of oasis-desert ecosystems, especially in the context of anthropogenic-induced over-development and perturbations due to climate variability that affects the sustainability of human-natural systems. Here, an investigation of the spatio-temporal variability of soil salinity and groundwater dynamics across four different hydrological regions in oasis-desert system is performed. An evaluation of the effects of soil salinization and groundwater degradation interplays on the coexistence of oasis-desert ecosystems in northwestern China is undertaken over 1995-2020, utilizing comprehensive measurements and ecohydrological modelling framework. We note that the process of salt migration and accumulation across different landscapes in oasis-desert system is reshaping, with soil salinization accelerating especially in water-saving agricultural irrigated lands. The continuous decline in groundwater tables, dramatic shifts in groundwater flow patterns and significant degradation of groundwater quality are occurring throughout the watershed. Worse so, a clear temporal-spatial relationship between soil salinization and groundwater degradation appearing to exacerbate the regional water-salt imbalance. Also, the eco-environmental flows are reaching to their limit with watershed closures, although these progressions were largely hidden by regional precipitation and streamflow variability. The oasis-desert ecosystems tend to display bistable dynamics with two preferential configurations of bare and vegetated soils, and soil salinization and groundwater degradation interplays are causing catastrophic shift in the oasis-desert ecosystems. The results highlight the importance of regional adaptive water and salt management to maintain the coexistence of oasis-desert ecosystems in arid areas.

Impact of intestinal flora on calcium oxalate stones. / è‚ é“èŒç¾¤å¯¹è‰é ¸é’™ç»“çŸ³çš„å½±å“.

Kidney stone is one of the common diseases of the urinary system. About 80% of kidney stones are mainly composed of calcium oxalate. As a huge bacterial network, the interaction of gut microbes is complex. Intestinal microbes may play a role in the pathogenesis and prevention of kidney stones. The intestinal flora of patients with calcium oxalate stones possess unique distribution of gut microbes. Oxalobacter formigenes, Bifidobacterium, Lactobacillus, Escherichia coli, and Providencia reteri bacteria are closely related to calcium oxalate stones, which provides new ideas for the prevention and treatment of urinary stones.

Improvements in physicochemical and nutrient properties of sewage sludge biochar by the co-pyrolysis with organic additives.

Sewage sludge (SS) has been suggested as a priming feedstock for biochar production that could simultaneously benefit the solid waste reuse and agricultural production. However, effects of organic additive (OA) addition on nutrient characteristic of SS biochar (SSB) are still unclear. Herein, a series of SSBs were produced from the co-pyrolysis of SS and OA with different types [reed straw (RS), brewers' spent grain (BSG), and sawdust (SD)] and addition rates (10%, 30%, and 50%) at 350 and 700 °C, respectively, and their basic physicochemical and nutrient properties were also analyzed. The results indicated that OA addition greatly increased the carbon (C) content, while significantly decreased the yield, ash content, pH, electrical conductivity, and elemental ratios of H/C, N/C, and O/C of SSB. These changes in SSB physicochemical properties would be more beneficial to its potentials of soil improvement and C sequestration. Furthermore, OA co-pyrolytic SSBs generally demonstrated similar nutrient retention rate and higher available nutrient content (e.g., Olsen P, K, and NH4+ - N) in relative to the SSBs from SS alone, indicating their excellent nutrient recovery capacity and higher nutrient utilization efficiency. Lastly, the SSBs produced from co-pyrolysis of SS and SD, BSG, and RS, respectively, with 50% addition rate and at 700 °C were suggested as the best SSB kinds used for soil application due to their highest comprehensive quality scores. In sum, co-pyrolysis of SS and OA is recommended as a promising strategy to increase the benefits of SSB in both agricultural production and environment.

Spatio-temporal dynamics and eco-hydrological controls of water and salt migration within and among different land uses in an oasis-desert system.

Identifying the eco-hydrological processes associated with water-salt dynamics is important for the sustainable management of water resources and eco-environmental systems in groundwater-dependent ecosystems, especially across different land use types in salt-affected oasis-desert ecosystems. In this study, a typical cropland-shelterbelt-desert site at the oasis-desert system in the Sangong River watershed of northwestern China was selected to investigate the spatio-temporal variations of water-salt dynamics using the Spearman rank correlation analysis and water/mass balance analysis, and to identify the response of vegetation dynamics to water-salt variations based on a model framework for vegetation-salinity-groundwater interactions, within and among these land uses during crop growth period (CGP: April 1-June 28, 2018) and non-crop-growth period (Non-CGP: June 29-October 31, 2018). Results showed that the soil water content (SWC) and soil electrical conductivity (SEC) had clear vertical stratification, horizontal transition and seasonal fluctuation characteristics during both CGP and Non-CGP. Significant differences in groundwater depth and salinity were exhibited between both study periods. The water exchange flux (WEF) and salt exchange flux (SEF) in both the cropland and shelterbelt were closely related to irrigation events and evidently higher than that in desert. The cropland maintained a salt accumulation state (especially at the >60-80 cm soil layer) during CGP. Hydrological links and salt transport processes among adjacent land uses have been weakened owing to the application of water-saving irrigation in cropland and the significantly declined of regional groundwater tables. Groundwater pumping and lateral groundwater flow (LGWF) were the most important media for water-salt exchange in the site. The interactions of vegetation with both the soil water-salt balance and groundwater dynamics may cause a discontinuous and irreversible ecosystem response to changes in land use or environmental conditions. Anthropogenic processes, especially the development of modern water-saving irrigation agriculture with groundwater-fed, are dominating the vegetation-salinity-groundwater interactions and its ecohydrological consequences in this ecosystem. Adaptive management of water and salt migration in soil and groundwater is essential for maintaining the coexistence of oasis-desert ecosystems in arid areas.