Subject(s)
Histiocytoma, Benign Fibrous/pathology , Hyperpigmentation/pathology , Mucinoses/pathology , Nevus/pathology , Adult , Biopsy, Needle , Comorbidity , Histiocytoma, Benign Fibrous/complications , Histiocytoma, Benign Fibrous/physiopathology , Humans , Hyperpigmentation/physiopathology , Immunohistochemistry , Male , Monitoring, Physiologic , Mucinoses/physiopathology , Nevus/physiopathology , PrognosisABSTRACT
We present an extremely rare case of low-grade cylindromatous adnexal carcinoma (CAC) on the right chest wall of a 77-year-old man. Histopathologically, the neoplasm was initially diagnosed as a cylindroma that developed over the course of 13 years. A diagnosis of low-grade CAC was rendered after the documentation of a local recurrence and histopathology of the recurrent tumor. To further assess the evolution of low-grade CAC over time, we compared the morphology, mitotic account, proliferative markers and adhesion molecule immunoreactivity among paired primary and recurrent tumors. Unlike those earlier reported, our case showed the maintenance of tumor morphology after a recurrence without areas of obvious malignant transformation or metaplastic change. We showed here for the first time the expression of adhesion molecules of CAC/spiradenoma and a comparison of proliferation indices between a primary tumor and its local recurrence. This peculiar tumor differs from previously reported cases and harbors a malignant potential although the histopathological features of malignancy are subtle. Our meta-analysis of the literature provided background information regarding this rare entity. Alterations of E-cadherin and GCDFP-15 expression may provide additional helpful clues in differential diagnosis and determining the clinical behavior of this unusual neoplasm. Further studies are warranted to confirm the potential discriminative role of these markers.
Subject(s)
Antimetabolites, Antineoplastic/administration & dosage , Lymphoma, Large-Cell, Anaplastic/drug therapy , Methotrexate/administration & dosage , Skin Neoplasms/drug therapy , Aged , Biomarkers, Tumor/analysis , Biopsy , Female , Humans , Immunohistochemistry , Injections, Intralesional , Lymphoma, Large-Cell, Anaplastic/chemistry , Lymphoma, Large-Cell, Anaplastic/immunology , Lymphoma, Large-Cell, Anaplastic/pathology , Skin Neoplasms/chemistry , Skin Neoplasms/immunology , Skin Neoplasms/pathology , Treatment OutcomeSubject(s)
Skin Diseases/therapy , Warts/therapy , Adult , Aged , Aged, 80 and over , Constriction , Female , Humans , Ligation/methods , Male , Middle Aged , Skin Diseases/virology , Warts/virologySubject(s)
CREST Syndrome/complications , Cryptococcosis/complications , Dermatomycoses/complications , Aged , Antifungal Agents/administration & dosage , Cryptococcosis/pathology , Dermatomycoses/pathology , Fingers/pathology , Fluconazole/administration & dosage , Humans , Immunocompromised Host , MaleSubject(s)
Anemia, Hemolytic, Autoimmune/pathology , Nocardia Infections/pathology , Purpura, Thrombocytopenic, Idiopathic/pathology , Skin Diseases/pathology , Adult , Anemia, Hemolytic, Autoimmune/complications , Anemia, Hemolytic, Autoimmune/drug therapy , Anti-Bacterial Agents/therapeutic use , Forearm/pathology , Humans , Male , Nocardia Infections/complications , Nocardia Infections/drug therapy , Purpura, Thrombocytopenic, Idiopathic/complications , Purpura, Thrombocytopenic, Idiopathic/drug therapy , Skin Diseases/drug therapy , Skin Diseases/microbiology , Syndrome , Treatment OutcomeSubject(s)
Diabetes Complications/diagnosis , Fat Necrosis/diagnosis , Aged, 80 and over , Fat Necrosis/etiology , Humans , MaleSubject(s)
Nails, Ingrown/therapy , Adult , Equipment Design , Female , Humans , Male , Therapeutics/instrumentationSubject(s)
Anticonvulsants/adverse effects , Drug Eruptions/diagnosis , Facial Dermatoses/diagnosis , Phenobarbital/adverse effects , Adult , Anticonvulsants/administration & dosage , Diagnosis, Differential , Dietary Supplements/adverse effects , Drug Eruptions/etiology , Drug Eruptions/pathology , Facial Dermatoses/chemically induced , Facial Dermatoses/pathology , Female , Humans , Internet , Phenobarbital/administration & dosage , Thorax/pathologyABSTRACT
In acne treatment, it is important to accurately evaluate the severity of Acne. The acne should be classified into several skin lesions including comedo, reddish papule, pustule, and scar. However, in some cases, a visual detection from RGB image maybe difficult for the proper evaluation of acne skin lesions. This paper proposes an extraction method using the spectral information of the various type of acne skin lesions calculated from the multispectral images (MSI) of the lesions. In the experiment, we showed the possibility of classifying acne lesion types by applying a combination of several linear discriminant functions (LDF's).
