ABSTRACT
Naevus sebaceus is a cutaneous hamartoma with the potential of developing into benign or malignant neoplasms. Syringocystadenoma papilliferum (SCAP) have been reported to originate from naevus sebaceus. SCAP is a rare, benign adnexal skin tumour of apocrine or eccrine type of differentiation which typically presents as a nodule or a plaque on the scalp or face. We report a case of syringocystadenoma papilliferum arising in an undiagnosed pre-existing naevus sebaceus in a 56-year-old female.
Subject(s)
Hamartoma/pathology , Skin Diseases/pathology , Sweat Gland Neoplasms/pathology , Tubular Sweat Gland Adenomas/pathology , Comorbidity , Diabetes Mellitus, Type 2/epidemiology , Female , Gout/epidemiology , Hamartoma/epidemiology , Humans , Hypertension/epidemiology , Middle Aged , Skin Diseases/epidemiology , Sweat Gland Neoplasms/epidemiology , Tubular Sweat Gland Adenomas/epidemiologySubject(s)
Antipruritics/administration & dosage , Pruritus/therapy , Administration, Cutaneous , Adult , Aged , Complementary Therapies , Drug Eruptions/complications , Ectoparasitic Infestations/complications , Emotions , Endocrine System Diseases/complications , Forecasting , Hematologic Diseases/complications , Humans , Infections/complications , Iron Deficiencies , Iron Overload/complications , Liver Diseases/complications , Mental Disorders/complications , Neoplasms/complications , Nervous System Diseases/complications , Phototherapy/methods , Primary Health Care , Pruritus/diagnosis , Pruritus/etiology , Uremia/complicationsABSTRACT
BACKGROUND: Patients with severe psoriasis, namely those requiring phototherapy or systemic treatment, have an increased risk of death. The aim of this study was to determine the prevalence, aetiology and risk factors for mortality among adult patients aged 18 years and above with psoriasis in Malaysia. METHODS: This was a retrospective study involving adult patients notified by dermatologists to the Malaysian Psoriasis Registry between July 2007 and December 2013. Data were cross-checked against the National Death Registry. Patients certified dead were identified and the cause of death was analysed. Multivariate analysis using multiple logistic regression were conducted on potential factors associated with higher risk of mortality. RESULTS: A total of 419 deaths were identified among the 9775 patients notified. There were four significant risk factors for higher mortality: age>40 years (age 41-60 years old, Odds Ratio (OR) 2.70, 95%CI 1.75, 4.18; age>60 years OR 7.46, 95%CI 4.62, 12.02), male gender (OR 1.72, 95%CI 1.33,2.22), severe psoriasis with body surface area (BSA) >10% (OR 1.52, 95%CI 1.19, 1.96) and presence of at least one cardiovascular co-morbidity (OR 1.67, 95% CI 1.30, 2.14). Among the 301 patients with verifiable causes of death, the leading causes were infection (33.9%), cardiovascular disease (33.6%) and malignancy (15.9%). CONCLUSION: Infection was the leading cause of death among psoriasis patients in Malaysia. Although cardiovascular diseases are well-known to cause significant morbidity and mortality among psoriasis patients, the role of infections and malignancy should not be overlooked.
Subject(s)
Chilblains/pathology , Cryoglobulinemia/complications , Skin Diseases, Vascular/pathology , Vasculitis/pathology , Comorbidity , Female , Humans , Leg , Middle AgedABSTRACT
We report a case of follicular porokeratosis of Mibelli affecting the natal cleft in a 42-year-old white man. To our knowledge, this is the first report in the English-language literature of follicular porokeratosis of Mibelli limited to the genitogluteal area.
