Exploratory analysis of social cognition and neurocognition in individuals at clinical high risk for psychosis.

Neurocognition and social cognition are separate but related constructs known to be impaired in schizophrenia. The aim of this study was to extend the current knowledge of the relationship between social cognition and neurocognition in individuals at clinical high risk (CHR) of developing psychosis by examining, in a large sample, the associations between a wide range of neurocognitive tasks and social cognition. Participants included 136 young people at CHR. Specific domains within neurocognition and social cognition were compared using Spearman correlations. Results showed that poor theory of mind correlated with low ratings on a wide range of neurocognitive tasks. Facial affect was more often associated with low ratings on spatial working memory and attention. These results support a link between neurocognition and social cognition even at this early stage of potential psychosis, with indication that poorer performance on social cognition may be associated with deficits in attention and working memory. Understanding these early associations may have implications for early intervention.

Treatment of herniated lumbar disk by sequestrectomy or conventional diskectomy.

BACKGROUND: The optimal surgical technique to treat disk herniation radiculopathy is uncertain. Advocates of sequestrectomy cite less perioperative pain and preserved disk architecture, whereas advocates of conventional diskectomy cite less frequent recurrent herniation. METHODS: Consecutive patients were evaluated retrospectively from 2 independent practices, one in which sequestrectomy was performed and one in which conventional diskectomy was performed. Demographic, radiographic, and outcomes data were analyzed to assess clinical results and incidence of recurrent herniation requiring further operation. Patients requiring further surgery were identified from a government-run provincial database independent of the surgeon performing the second procedure. RESULTS: Among 172 patients (98 conventional diskectomy procedures, 74 sequestrectomy procedures), there were no significant differences in age, gender, smoking status, or level of disk herniation. Conventional diskectomy was not associated with greater blood loss, longer surgery, or longer length of stay compared with sequestrectomy. At 3-month follow-up, approximately 85% of patients improved clinically regardless of the procedure performed. However, recurrent herniation over 6 years median follow-up requiring further surgery was lower among patients receiving conventional diskectomy (10% overall, 6% same-level, 4% adjacent-level) compared with sequestrectomy (19% overall, 15% same-level, 4% adjacent-level). CONCLUSIONS: No clinical advantage was found to performing a limited sequestrectomy instead of conventional microdiskectomy for the treatment of radiculopathy owing to lumbar disk herniation. Conversely, the incidence of recurrent disk herniation requiring revision surgery was lower in patients treated by more aggressive disk removal.