ABSTRACT
Addressing external disturbances has been a critical issue for control design to ensure reliable operation of systems. This article investigates the tracking control problem for the uncertain nonlinear systems with the strong external disturbance and the prescribed performance. The flexible performance-based control scheme is developed by introducing an external disturbance criterion into the prescribed performance. It is capable of guaranteeing the prescribed performance if the external disturbance is less than a specified threshold and degrading that in light of the user-appointed rule otherwise. Particularly, the disturbance interval observer is synthesized to generate the boundaries of the external disturbances and realize the judgment of that criterion. With the generated boundaries, the interval-type auxiliary system is designed to provide the modified performance functions (MPFs) that characterize performance requirement and degradation rule simultaneously. Based on the positive system theory and the Lyapunov method, it is theoretically shown that the system output can always track the reference signal and satisfy the constraints of MPFs. Finally, both the numerical simulation and the application of flight control design verify that the results are effective and valid.
ABSTRACT
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, and transforming growth factor-ß1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.
