ABSTRACT
@#AIM:To observe the clinical application effect of regional refraction intraocular lens SBL-3 in patients with age-related cataract.<p>METHODS: Totally 90 patients(90 eyes)with age-related cataract diagnosed and treated in our hospital from February 2016 to December 2017 were selected as the study object, and they were randomly divided into control group and observation group, each group respectively included 45 cases(45 eyes). The control group were treated with single focus intraocular lens implantation, the observation group were treated with regional refraction intraocular lens SBL-3. Then the naked vision, VF-14 scale and corneal endothelial cells situation before and after the operation, contrast sensitivity after the operation of two groups were compared.<p>RESULTS: The naked vision, VF-14 scale and corneal endothelial cells of two groups before the operation were compared,the differences had no statistical significance(all <i>P</i>>0.05). After 12wk operation, the naked vision and VF-14 scale of observation group were better than those of control group, and contrast sensitivity of light and dark light were all lower than those of control group, the differences had statistical significance(all <i>P</i><0.05), while the corneal endothelial cells, contrast sensitivity of light glare and dark glare of two groups were compared, the differences had no statistical significance(all <i>P</i>>0.05).<p>CONCLUSION: The clinical application effect of regional refraction intraocular lens SBL-3 in the patients with age-related cataract is better which has positive improvement effect for the visual quality, and the bad influence for the cornea is small, so its clinical application value is higher.
ABSTRACT
OBJECTIVE: To establish an experimental model of acute cerebral schistosomiasis japonica and explore the MRI manifestations of acute cerebral schistosomiasis. METHODS: Rabbits were divided into 3 groups with 10 rabbits in each group. The rabbits in the experimental group were directly injected with suspension fluid of Schistosoma japonicum eggs (0.9 mg, 1 ml) by the cranial drilling method, those in the negative control group were given saline (1 ml) by the same method above-mentioned, and those in the blank control group were not given any treatment. Antibiotic was given to the first two groups after the operation. The clinical manifestations of the 3 groups were observed, and the magnetic resonance imaging (MRI) was performed in 30 days post-operation, and then the brain tissues were taken for pathological examinations. RESULTS: All the rabbits in the experimental group exhibited inappetence, various neurological symptoms including hemiplegia, and weight loss after the operation; while those in the negative control group showed inappetence in 3 days after the operation, and 1 week later, the symptom disappeared; there were no adverse reactions in the blank control group. MRI of the experimental group showed nodular or patchy enhancement on T1WI enhancement, brain edema, abnormal ventricular dilatation, and needle augmentation. SWI displayed hypointense in the abnormal enhanced nodules and flaky hypointense on the operation brain. In the negative control group, 2 rabbits showed abnormal enhancement of the needle canal, and 1 showed mild dilatation of the ventricle. The blank control group showed normal manifestations. The pathological examinations showed abnormal appearances in 10 rabbits of the experimental group, including 6 with S. japonicum egg granuloma nodules, nonspecific granuloma nodules coexisted with perivascular inflammation; no granuloma nodules were found in the negative control group, but 2 rabbits showed vascular inflammation; the blank control group showed the normal brain tissue. CONCLUSIONS: An experimental model of acute cerebral schistosomiasis is successfully established in rabbits by intracranial injection of schistosome eggs. The MRI examination combined with the clinical manifestations can improve the accuracy of early diagnosis of cerebral schistosomiasis.
