Localized Amyloidosis of the Prostate / 대한비뇨기과학회지

The increasing number of prostatic biopsies, performed for the investigation of patients at risk of prostate cancer, will result in the more frequent identification of uncommon forms of prostatic pathology. Amyloidosis is a disease characterized by the extracellular deposition of insoluble amyloid fibrils, and may be either systemic or localized. Localized amyloidosis of the prostate is very rare. Herein, we report the case of a 34-year-old man with localized amyloidosis of the prostate, which was found via a transrectal ultrasound-guided prostatic biopsy due to an increased serum prostate-specific antigen level.

A Pilot Study of HRV(Heart Rate Variability) in Patient with Urinary Incontinence

PURPOSE: To compare autonomic dysfunction in patients with urge urinary incontinence(UUI), patients with stress urinary incontinence(SUI) and normal group, we measured and analyzed heart rate variability to compare among the three groups. MATERIALS AND METHODS: We studied heart rate variability(HRV) in 30 patients with UUI(mean age, 47.7+/-10.0 years old), 40 patients with SUI(mean age, 47.6+/-8.7 years old), 120 healthy controls(mean age 45.2+/-6.9 years old). The parameters of HRV of the three groups were compared. RESULTS: There was no difference in uroflowmetry and heart rate among the three groups. In time domain, square root of the mean squared difference of successive N-N interval(RMSSD) in UUI was higher than that of the others, and standard deviation of N-N interval(SDNN) showed no difference. In frequency domain, low frequency(LF) in UUI, an indicator of cardiac sympathetic tone, was higher than thar of the others. Very low frequency(VLF), LF, low-frequency/high-frequency ratio(LF/HF ratio) didn't show difference. CONCLUSION: All parameters of HRV analysis in UUI were not same as those of SUI and controls. The increase in RMSSD and HF means that there could be imbalance in autonomic nervous system and it could be the cause of detrusor overactivity in UUI.

Analysis of Heart Rate Variability in Patients BPH

PURPOSE: To characterize autonomic dysfunction in patients with benign prostatic hyperplasia(BPH), we measured heart rate variability(HRV) and analyzed them compared with those of normal population. MATERIALS AND METHODS: ECG signals were obtained from 11 male patients(mean age, 63.1 years) and 23 healthy male controls(mean age, 57.0 years) in resting state. We analyzed their parameters of HRV and compared them between groups. RESULTS: Time domain analysis including standard deviation of NN interval(SDNN), square root of mean of sum of squares of differences between adjacent NN intervals(RMSSD) in patients with BPH were not significantly different with those of controls. There were suggested evidence of decreased total power(TP), high frequency (HF) in patients with BPH(p<0.05) while no significant difference in other frequency domain such as very low frequency(VLF), low frequency(LF) and LF/HF ratio. CONCLUSION: This preliminary study shows that patients with BPH have different results on HRV study comparing to controls. With the exception of LF and LF/HF ratio, all parameters of HRV in patients with BPH lower than normal controls. TP, HF in patients with BPH significantly lower than that of normal controls. The decreased values of HRV study means that they may have some kinds of disease or imbalance in autonomic nervous system(ANS). So we suggest that HRV study may be a tool to describe the possibility of altered ANS activity in patients with BPH.

The Change of Mast Cell and Smooth Muscle Contractility of Trachea, Intestine and Urinary Bladder in Sensitized Rats / 대한비뇨기과학회지

PURPOSE: We used the sensitized rat model to study the effect of the inflammation evoked by immune response on the smooth muscles of the urinary bladder, trachea and intestine and changes of mast cell. MATERIALS AND METHODS: The rats were divided into 3 groups (group 1: control - not-sensitized. no antigen challenge, group 2: sensitized, no antigen challenge, group 3: sensitized, antigen challenge). Each group was divided into two subgroups of male and female. Rats were sensitized by intraperitoneal injection of ovalbumin (10mg/ml/kg) given on days 1, 3 and 5, 4 weeks after last injection, sensitized rats were treated with intravesical ovalbumin for 1 hour (antigen challenge) and controls runned simultaneously with the unsensitized rats by intravesical instillation of normal saline. After intravesical instillation contractility and number of mast cells of each organ were measured. RESULTS: Only female-sensitized group showed significantly increased contractility of bladder muscle (p<0.05) while no significant difference in trachea and intestine among groups. In male rats there were no significant differences between groups and organs. In male and female groups, there was increased contractility in female rats than male but showed no significant difference between sexes. In histologic study, sensitized, ovalbumin group showed more mast cells in detrusor muscle and submucosa than non-sensitized, saline group in both male and female rats. Also there were significant differences in female rats than male rats. Detrusor to submucosa mast cell ratio was significantly higher in sensitized, ovalbumin group. CONCLUSIONS: We concluded that there might be some other factors that made differences in response to antigen challenge between sexes and among the organs. We observed increased contractility in female rat bladder and this may explain higher incidence of interstitial cystitis in female than male.