A 3-month-old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism.

Coxsackievirus B1 (CVB1), an enterovirus with multiple clinical presentations, has been associated with potential long-term consequences, including hand, foot, and mouth disease (HFMD), in some patients. However, the related animal models, transmission dynamics, and long-term tissue tropism of CVB1 have not been systematically characterized. In this study, we established a model of CVB1 respiratory infection in rhesus macaques and evaluated the clinical symptoms, viral load, and immune levels during the acute phase (0-14 days) and long-term recovery phase (15-30 days). We also investigated the distribution, viral clearance, and pathology during the long-term recovery period using 35 postmortem rhesus macaque tissue samples collected at 30 days postinfection (d.p.i.). The results showed that the infected rhesus macaques were susceptible to CVB1 and exhibited HFMD symptoms, viral clearance, altered cytokine levels, and the presence of neutralizing antibodies. Autopsy revealed positive viral loads in the heart, spleen, pancreas, soft palate, and olfactory bulb tissues. HE staining demonstrated pathological damage to the liver, spleen, lung, soft palate, and tracheal epithelium. At 30 d.p.i., viral antigens were detected in visceral, immune, respiratory, and muscle tissues but not in intestinal or neural tissues. Brain tissue examination revealed viral meningitis-like changes, and CVB1 antigen expression was detected in occipital, pontine, cerebellar, and spinal cord tissues at 30 d.p.i. This study provides the first insights into CVB1 pathogenesis in a nonhuman primate model of HFMD and confirms that CVB1 exhibits tissue tropism following long-term infection.

Meta-analysis of acupuncture intervening exercise-induced fatigue / 针灸推拿医学（英文版）

Objective: To systematically evaluate the impact of acupuncture on exercise-induced fatigue (EIF). Methods: Scopus, Springer Link, Web of Science, PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Academic Journal Full-text Database (Wanfang), Chongqing VIP Database (CQVIP), and China Biology Medicine Disc (CBM) were systematically searched to identify randomized controlled trials (RCTs) studying acupuncture treatment of EIF from the inception till August 2020. The risk of bias in the included studies was assessed using the Cochrane handbook. RevMan 5.3 was used to conduct statistical analysis on the extracted data. Results: A total of 11 RCTs were included for meta-analysis, involving 531 patients. It was revealed that acupuncture produced more significant effects in alleviating subjective fatigue [standardized mean difference (SMD)=-3.08, 95％ confidence interval (CI) (-4.35, -1.81), P<0.001], increasing the hemoglobin content [weighted mean difference (WMD)=3.89, 95％CI (1.37, 6.42), P=0.003], reducing the lactate dehydrogenase content [WMD=-10.63, 95％CI (-17.67, -3.59), P=0.003], reducing the blood lactic acid content [SMD=-2.65, 95％CI (-4.47, -0.83), P=0.004], and down-regulating the levels of serum creatine kinase [SMD=-0.79, 95％CI (-1.10, -0.48), P<0.001] and blood urea nitrogen [WMD=-1.47, 95％CI (-1.84, -1.11), P<0.001] than the control groups. Conclusion: Based on the existing evidence, acupuncture can be recognized as effective in improving EIF and is worthy of promotion in clinical settings.

Effects of dance training on cognitive functioning and the emotional state of people with Parkinson′s disease: A meta-analysis / 中华物理医学与康复杂志

Objective:To assess systematically the effect of dance training on the cognitive functioning and emotional state of people with Parkinson′s disease.Methods:Randomized controlled trials (RCTs) of the effect of dance training on the cognition and emotional state of people with Parkinson′s disease were retrieved from the Pubmed, Embase, Cochrane Library, Web of Science, Science Direct, Ovid, CNKI, Wan fang and VIP databases. The period was from January 1995 to January 10, 2019. The literature was screened, collected and evaluated by two reviewers independently. The meta-analysis was conducted using version 5.3 of the Revman software.Results:Seven RCTs involving 167 patients were discovered. According to the meta-analysis, dance training significantly relieved depression [SMD=-0.75, 95%CI: -1.41 to -0.10]. It improved the average score on the Montreal Cognitive Assessment Scale [WMD=2.05, 95%CI: 0.87 to 3.23] and on the Frontal Assessment Battery [WMD=1.41, 95%CI: 0.49 to 2.33]. However, dance training could not effectively improve apathy.Conclusions:Current evidence shows that dance training can relieve depression and promote better cognitive functioning for people with Parkinson′s disease.

SCOAT-Net: A Novel Network for Segmenting COVID-19 Lung Opacification from CT Images

The new coronavirus disease 2019 (COVID19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide at a rapid rate. There is no clinically automated tool to quantify the infection of COVID-19 patients. Automatic segmentation of lung opacification from computed tomography (CT) images provides excellent potential, which is of great significance for judging the disease development and treatment response of the patients. However, the segmentation of lung opacification from CT slices still faces some challenges, including the complexity and variability features of the opacity regions, the small difference between the infected and healthy tissues, and the noise of CT images. Besides, due to the limited medical resources, it is impractical to obtain a large amount of data in a short time, which further hinders the training of deep learning models. To answer these challenges, we proposed a novel spatial and channel-wise coarse-to-fine attention network (SCOAT-Net) inspired by the biological vision mechanism, which is for the segmentation of COVID-19 lung opacification from CT Images. SCOAT-Net has the spatial-wise attention module and the channel-wise attention module to attract the self-attention learning of the network, which serves to extract the practical features at the pixel and channel level successfully. Experiments show that our proposed SCOAT-Net achieves better results compared to state-of-the-art image segmentation networks.

Mechanical sensitivity analysis and optimization of a large-aperture KDP frequency converter for higher SHG efficiency.

The effective energy density at the target of inertial confinement fusion facility is subject to the problem of the low efficiency of second harmonic generation of large-aperture KDP frequency converters over a long time. To overcome this problem, we propose the optomechanical analysis method to correlate the mechanical factors with its critical physical performance in theory. Further, combined with experiments and simulations, the mechanical sensitivity of the frequency converter is completely explained from the microscopic and macroscopic perspectives. Finally, we introduce a moment-dominated clamping scheme that is expected to greatly improve the online service performance of the converter.

Clinical Features and Surgical Management of Cerebellopontine Angle Cholesteatoma That Presented as Trigeminal Neuralgia.

BACKGROUND: It is difficult to differentiate patients with cerebellopontine angle (CPA) cholesteatoma and patients with primary trigeminal neuralgia just according to early symptoms. We aimed to explore the clinical characteristics, early diagnosis, and microneurosurgical techniques for CPA cholesteatoma that presented as trigeminal neuralgia. METHODS: The data of 26 patients who complained trigeminal neuralgia with CPA cholesteatoma between January 2009 and December 2015 were collected and studied retrospectively, they were diagnosed by magnetic resonance imaging preoperatively and confirmed by pathology postoperatively. All the tumors were resected through a retrosigmoidal approach. In 26 cases, 14 patients who underwent cholesteatoma resection and microvascular decompression were assigned to group A and 12 patients who underwent only cholesteatoma resection were assigned to group B. The clinical features and surgical results between groups A and B were compared. The complications and surgical results were followed up, and surgical techniques were summarized. RESULTS: All patients presented as trigeminal neuralgia at the same side of the cholesteatoma. There was no statistical difference between the 2 groups in clinical features and surgical results between groups A and B. All patients with cholesteatoma showed clear and significant imaging characteristics. The tumors were totally removed in 18 patients and subtotally removed in 8 patients. Pain relief was satisfactory in all patients. Surgical complications included transient aseptic meningitis in 2 patients, facial numbness in 2 patients, mild tinnitus in 2 patients, mild and facial weakness in 1 patient. No death, hematoma, or acute hydrocephalus were reported in this series. During the follow-up of 12-80 months, no patient experienced recurrence of pain or tumor. CONCLUSIONS: Cholesteatoma of the cerebellopontine angle often presented as trigeminal neuralgia. Magnetic resonance imaging is helpful for early diagnosis according to its distinct signal. Surgical treatment is often the first choice, the neuralgia relief was satisfactory after operation. Microvascular decompression is recommended simultaneously if some offending vessels were founded during the surgical resection of the tumor.

The therapeutic effect of percutaneous microwave ablation in treatment of focal uterine adenomyosis / 中华医学超声杂志（电子版）

Objective To observe and analyze the therapeutic effect of focal uterine adenomyosis treated with percutaneous microwave ablation by contrast-enhanced ultrasound and dynamic contrast enhanced MRI (DCE-MRI).Methods From January 2013 to July 2016,42 patients with focal uterine adenomyosis voluntarily underwent percutaneous microwave ablation in the tumor hospital of Liaocheng.Contrast-enhanced ultrasound and DCE-MRI were performed before and after percutaneous microwave ablation.The therapeutic effects of percutaneous microwave ablation in treatment of uterine adenomyosis lesions were observed.Results After percutaneous microwave ablation of the 42 cases,the ablated zone showed no enhancement with contrast-enhanced ultrasound and DCE-MRI.Contrast-enhanced ultrasound showed that the volume and ablation rate of ablated zone were (49.0±29.5) cm3 and (91.6± 7.1)％,and that of DCE-MRI were (49.4 ± 29.9)cm3 and (91.9 ± 6.7)％,respectively.The results showed that percutaneous microwave ablation could cure focal uterine adenomyosis at the rate over 90％.Contrast-enhanced ultrasoundand DCE-MRI are in accordance in observing the ablation rate.Conclusions Contrast-enhanced ultrasound can accurately show the ablation rate of focal uterine adenomyosis treated with percutaneous microwave ablation,which is quite consistent with DCE-MRI.Contrast-enhanced ultrasound has its advantages such as identifying the lesions which need immiedately supplemental ablation.

Clinical study on microwave ablation combined with concurrent chemotherapy in treatment of locally advanced pancreatic cancer / 肿瘤研究与临床

Objective To investigate the clinical efficacy and safety of microwave ablation combined with concurrent chemotherapy in treatment of locally advanced pancreatic cancer. Methods Thirty-one patients with locally advanced pancreatic cancer with between August 2013 and April 2016 were divided into two groups according to the different treatments: 15 patients in the control group were treated with gemcitabine monotherapy; 16 patients in the combination group were treated with the same regimen as control group 1-2 weeks after the microwave ablation. The efficacy and side effects of the two groups were compared by chi-square test. Results The effective rates in the combination group and control group were 25.0%(4/16) and 13.3%(2/15), the difference between the two groups was not significant (χ 2=1.034, P=0.247); the local control rates were 68.8%(11/16) and 26.7%(4/15), the difference between the two groups was statistically significant (χ2=6.579, P=0.012). The pain relief rates in the combination group and control group were 87.5%(14/16) and 26.7%(4/15) (χ2=8.146, P=0.004). The 3-, 6-, 9- and 12-month survival rates in the combination group and control group were 100.0%vs. 100.0%(P=1.000), 68.8%vs. 40.0%(P=0.097),56.3%vs.20.0%(P=0.033),50.0%vs.13.3%(P=0.021).In the combination group,9 cases (56.3%)occurred postablation syndrome,the serum amylase of 7 cases(43.8%)increased 1d after ablation,1 case (6.3%) occurred pancreatic fistula. The intraoperative and perioperative death did not occur. The main complications of the two groups were myelosuppression, gastrointestinal reactions and so on. Conclusions Microwave ablation combined with concurrent chemotherapy has a synergistic effect in treatment of locally advanced pancreatic cancer. In disease control rate, pain relief rate and survival of patients, microwave ablation combined with concurrent chemotherapy is better than chemotherapy alone, but the adverse reactions are similar.

Clinical study on microwave ablation combined with concurrent chemotherapy in treatment of locally advanced pancreatic cancer / 肿瘤研究与临床

Objective To investigate the clinical efficacy and safety of microwave ablation combined with concurrent chemotherapy in treatment of locally advanced pancreatic cancer. Methods Thirty-one patients with locally advanced pancreatic cancer with between August 2013 and April 2016 were divided into two groups according to the different treatments: 15 patients in the control group were treated with gemcitabine monotherapy; 16 patients in the combination group were treated with the same regimen as control group 1-2 weeks after the microwave ablation. The efficacy and side effects of the two groups were compared by chi-square test. Results The effective rates in the combination group and control group were 25.0%(4/16) and 13.3%(2/15), the difference between the two groups was not significant (χ 2=1.034, P=0.247); the local control rates were 68.8%(11/16) and 26.7%(4/15), the difference between the two groups was statistically significant (χ2=6.579, P=0.012). The pain relief rates in the combination group and control group were 87.5%(14/16) and 26.7%(4/15) (χ2=8.146, P=0.004). The 3-, 6-, 9- and 12-month survival rates in the combination group and control group were 100.0%vs. 100.0%(P=1.000), 68.8%vs. 40.0%(P=0.097),56.3%vs.20.0%(P=0.033),50.0%vs.13.3%(P=0.021).In the combination group,9 cases (56.3%)occurred postablation syndrome,the serum amylase of 7 cases(43.8%)increased 1d after ablation,1 case (6.3%) occurred pancreatic fistula. The intraoperative and perioperative death did not occur. The main complications of the two groups were myelosuppression, gastrointestinal reactions and so on. Conclusions Microwave ablation combined with concurrent chemotherapy has a synergistic effect in treatment of locally advanced pancreatic cancer. In disease control rate, pain relief rate and survival of patients, microwave ablation combined with concurrent chemotherapy is better than chemotherapy alone, but the adverse reactions are similar.

Strategies for storage and sharing of postgraduate dissertations in medical colleges and universities / 中华医学图书情报杂志

Described in this paper are the strategies for rational storage and sharing of postgraduate dissertations in medical colleges and universities with the development of dissertations and its related problems in Library of Capital Medical University as an example.

Correlations between occupational stress and care ability of nurses in operating room / 现代临床护理

Objective To investigate the correlations between occupational stress and care ability of nurses in operating room.Method Occupational stress scale and caring ability evaluation scale were used for the investigation among 180 nurses in 4 general hospitals in Beijing.Results Occupational stress scale (405.61±27.44) and nurses' operating ability (189.07±16.82) in the operating rooms were negatively correlated (P ＜0.05).The occupational stress was negatively correlated with caring ability of the nurses from the operating room.Conclusions Occupational stress of the nurses from the operating room is at the middle level.The care ability is low generally.The occupational stress of the nurses in the operating room is lower and the care ability is higher.Nurse manager can create good working environment,streathing human resource magement to reduce nurse's working stress,thus increase working quality.

Impacts of ethanol on the epidermal growth factor receptor (EGFR) -calpain signaling and migration in breast cancer cells / 中国癌症杂志

Background and purpose:Ethanol has been reported to stimulate progression of breast cancer, yet the underlying mechanism is not fully understood. This study aimed to investigate effects of ethyl alcohol (EtOH) on the calcium-activated neutral protease (CANP)-cyclin E/focal adhesion kinase (FAK) signaling and cell migration in breast cancer cells, as well as the role of epidermal growth factor receptor (EGFR) in the EtOH-stimulated effects, in order to assess the signaling mechanism(s) underlying how EtOH enhances cancer progression.Methods:Human breast cancer cell line MCF-7 was employed as a model system, with MCF-10A mammary epithelial cells as control. In vitro wound healing assay was carried out to evaluate EtOH-induced cell migration. The effects of EtOH or epidermal growth factor on the proteolysis of cyclin E/FAK were detected by Western blot. EGFR inhibitor (EGFR-I) and a speciifc inhibitor for CANP, Calpeptin, were applied to pretreat cultured cells to explore their inlfuences on the cell migration and cyclin E/FAK proteolysis triggered by EtOH.Results:Treatment of model cells with EtOH (0.3%) stimulated significant proteolysis of cyclin E/FAK in a dose-/time-dependent manner and increased migration (+47.30%,P<0.05) in MCF-7 breast cancer cells, but had no signiifcant effect on migration in MCF-10A cells. Pretreatment with Calpeptin (10 μmol/L) signiifcantly reduced EtOH (0.3%)- or EGFR (10 ng/mL)-induced cyclin E/FAK truncation. EGFR-I (3 μmol/L) pro-foundly reduced EtOH-indcued CANP dependent proteolysis of CANP1 and cyclin E/FAK as well as cell migration (-53.00%,P<0.01).Conclusion:EtOH signiifcantly stimulates activation of CANP via EGFR pathway, resulting in proteolysis of cyclin E/FAK and migration in MCF-7 breast cancer cells, suggesting EGFR-CANP signaling to be a potential target for suppression of metastasis in breast cancer.

Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1-40-induced toxicity

Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. Quercetin is a natural flavonoid molecule and has been demonstrated to have potent neuroprotective effects, but its protective effect on endothelial cells under Aβ-damaged condition is unclear. In the present study, the protective effects of quercetin on brain microvascular endothelial cells injured by fibrillar Aβ 1-40 (fAβ 1-40) were observed. The results show that fAβ 1-40-induced cytotoxicity in human brain microvascular endothelial cells (hBMECs) can be relieved by quercetin treatment. Quercetin increases cell viability, reduces the release of lactate dehydrogenase, and relieves nuclear condensation. Quercetin also alleviates intracellular reactive oxygen species generation and increases superoxide dismutase activity. Moreover, it strengthens the barrier integrity through the preservation of the transendothelial electrical resistance value, the relief of aggravated permeability, and the increase of characteristic enzyme levels after being exposed to fAβ 1-40. In conclusion, quercetin protects hBMECs from fAβ 1-40-induced toxicity.

A systematic review of Comfeel transparent dressing for preventing PICC-associated phlebitis / 中国实用护理杂志

Objective We aimed to systematically review the effect of Comfeel transparent dressing for preventing PICC-associated phlebitis.Methods We electronically searched in China National Knowledge Infrastructure (CNKI),Chinese Science Technology Periodical Databases (VIP),Wanfang Database,China Biology Medicine Disc (CBM),PubMed and Embase for studies about effect of Comfeel transparent dressing for preventing PICC-associated phlebitis from inception to June 2014.Literature was screened and evaluated by inclusion and exclusion criterion.The RevMan 5.1 software was used for Meta-analysis.Results This study included 7 RCTs involving 524 patients.Meta analysis showed that compared with the 3M occlusive dressing,Comfeel transparent dressing could significantly decrease the incidence of PICC-associated phlebitis,OR=0.17,95％CI (0.08,0.34),Z=4.95,P＜0.01.Conclusions Comfeel plus transparent dressing can prevent the incidence of PICC-associated phlebitis.

Implementation and demand of lectures on information resources in academic libraries / 中华医学图书情报杂志

After the links of lectures on use of information resources in Library Capital Medical University were de-scribed, the implementation steps of lectures and our experiences were summarized, and the demand of readers for such lectures was analyzed with suggestions proposed for the position and popularization, Website platform building and brand construction of lectures in order to promote such lectures, help readers to effectively use the databases in libraries and expand the influencing power of libraries.

Curative observation of ultrasound-guided microwave ablation therapy for hepatocellular carcinoma combined with arterio-venous fistula / 中华超声影像学杂志

Objective To observe the curative effect of the microwave ablation (MWA) therapy for hepatocellular carcinoma (HCC) with arterio-venous fistula (AVF) in patients with intervention and operative contraindication,and to observe the clinical effect.Methods MWA therapy was offered to 24 patients with HCC combined with AVF accompanied with intervention and operative contraindication.The complete ablation rates,volume changes of tumors before and after treatment were observed.Color Doppler ultrasonography was performed to evaluate the peak flow rate and resistance index(RI)of AVF,width and flow rate change of portal vein.The lifetime of patients were also observed.Results All patients were treated with double needle therapy.The first time complete ablation was 75.0％ (18/24).Then they were followed up after 6 months.The volume of tumors was (72.9 ± 23.8)cm3 and (57.6 ± 19.8)cm3 (P ＜0.01) before and after treatment.The AVF disappeared in 20 cases,while flow rates of fistula orifice decreases obviously in the rest of them.The widths of portal veins decreased from (1.4 ± 0.9)cm to (1.3 ± 0.1)cm,while the flow rate of that increased from (7.5 ± 3.9)cm/s to (20.1 ± 2.9)cm/s.The survival rates of patients for one,two and three years were 66.6 ％ (16/24),37.5 ％ (9/24) and 20.8 ％ (5/24),respectively.Conclusions Most AVF disappeared after MWA therapy in HCC combined with AVF.The therapy can relieve portal hypertension symptom effectively and improve survival time and life quality of patients.So it is a good treatment for patients with HCC combined with AVF while with intervention and operative contraindication.

Estrogen regulates anoikis through extracellular signal-regulated kinase (ERK)-focal adhesion kinase (FAK) signaling in MCF-7 breast cancer cells / 基础医学与临床

Objective To investigate the effects of estrogen ( E2) on the resistance to anoikis and a possible role of extracellular signal-regulated kinse ( ERK)-focal adhesion kinse ( FAK) signaling in the effect of estrogen to under-stand its underlying mechanism .Methods Poly-Hema-coated culture of human breast cancer cell line MCF-7 was used to induce anoikis .Cells were treated with E2 and/or pretreated with MEK or FAK inhibitors .Western blot was used to assess the phosphorylation of ERK and FAK , trypan blue staining and cell counting were employed to evaluate cell viability , and Hoechst staining was used to check apoptosis .Results Suspension culture greatly re-duced cell survival (P<0.01), and exposure of MCF-7 cells to E2 (10 nmol/L) led to a significantly increased resistance to anoikis and survival ( P<0.05 ) as compared to DMSO .Meanwhile , E2 induced increased phospho-rylation of both ERK and FAK .Pharmacological inhibition of MEK with U 0126 ( 10 μmol/L ) reduced E2-in-creased cell survival by 57.48%(P<0.01) and E2-decreased anoikis;Treatment with FAK inhibitor (10μmol/L) attenuated E2-enhanced cell survival by 53.59% ( P<0.01 ) and E2-reduced apoptosis .Conclusions E2 con-tributes to the enhanced cell viability and increased resistance to anoikis in MCF-7 breast cancer cells , and ERK-FAK signaling may be involved in the E 2-stimulated survival during suspension culture of MCF-7 cells.

Preliminary study of transrectal ultrasound-guided lauromacrogol injection for treating benign prostate ;hyperplasia in elderly patients / 中华超声影像学杂志

Objective To observe the preliminary curative effect of transrectal ultrasound-guided lauromacrogol injection for treating benign prostate hyperplasia in elderly patients.Methods Forty-two patients with benign prostate hyperplasia combined with lower urinary tract symptonms received transrectal ultrasound-guided lauromacrogol injection.Then they were followed up after 3,6,12 months respectively. Prostate volume changes before and after treatment,international prostate symptom score(IPSS),postvoid residual volume (PRV ),maximum urinary flow rate (Qmax ) and features of contrast-enhanced ultrasonography before and after treatment were observed.Complications were analyzed.Results Before treatment,prostate volume,IPSS,PVR of patients were (57.3±1 7.7)ml,(28.3 ±5.2)points,(143.8±82.5) ml respectively,12 months after treatment,they reduced to (44.8 ±6.1 )ml,(8.8 ± 1 .4)points,(28.9 ±9.5 ) ml,there were statistical diffrences between before and after treatment(P <0.05 ).Qmax increased from (5.9±3.2)ml/s to (14.9 ±3.1 )ml/s (P <0.05).Contrast-enhanced ultrasonography showed filling defect sign in prostatic inner gland.No serve complications occurred.Conclusions Transrectal ultrasound-guided lauromacrogol injection for treating benign prostate hyperplasia has the characteristics of minimally invasive,safe,effective and economical.It applies to elderly patients who are unable or unwilling to have surgery.

Long-term results of selective dorsal rhizotomy for hereditary spastic paraparesis.

Pure hereditary spastic paraparesis usually presents with progressive weakness and spasticity of the legs, which is similar to spastic cerebral palsy. In this study selective dorsal rhizotomy (SDR) was performed to improve the spasticity of pure hereditary spastic paraparesis and the long-term results were followed. A series of four patients with pure hereditary spastic paraparesis diagnosed by a multidisciplinary team received SDR. The dorsal rootlets from the L2 to S1 levels were selectively resected under electrophysiological monitoring. The patients were followed up for more than 2 years to evaluate the outcome of surgery. There was a significant reduction in muscular spasm after SDR. Standing and walking stability were improved in all patients which led to improvement in walking posture and longer walking distance without assistance. No urinary retention, cerebrospinal fluid leak, surgical infection or kyphosis occurred. For severe pure hereditary spastic paraparesis, SDR can reduce muscle spasm and improve standing and walking stability. These results were stable throughout follow-up. SDR performed at the level of the conus medullaris through a laminectomy from T12 to L1 or L1 to L2 requires a shorter incision, laminectomy of fewer segments, and has a shorter operation time than the usual method (laminectomy from L2 to S1). Intraoperative electrophysiological monitoring is helpful to discriminate abnormal rootlets and protect sphincter function.

Application of laparoscopic technique in the treatment of traumatic colorectal perforation / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To explore the efficacy and the security of laparoscopic technique in patients with traumatic colorectal perforation.</p><p><b>METHODS</b>Clinical data of 42 patients with traumatic colorectal perforation in our hospital during March of 2005 to March of 2013 were retrospectively analyzed. Twenty-two patients received traditional open operation, and 20 patients received laparoscopic treatment.</p><p><b>RESULTS</b>As compared to open group, laparoscopic group had shorter operation time [(72 ± 36) min vs. (128 ± 52) min], less blood loss during operation [(21.2 ± 3.6) ml vs. (62.6 ± 8.8) ml], faster postoperative bowel function return[(1.7 ± 0.6) d vs. (3.5 ± 1.2) d], shorter hospital stay after operation [(7.3 ± 1.8) d vs. (13.6 ± 3.9) d], and lower incidence of postoperative complication [35.0% (7/20) vs. 72.7% (16/22)]. The differences between two were statistically significant (all P<0.05).</p><p><b>CONCLUSION</b>Laparoscopic operation has advantages in the treatment of traumatic colorectal perforation with short operation time, small trauma, rapid recovery and low incidence of complications.</p>