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Chem Pharm Bull (Tokyo)
; 69(8): 781-788, 2021.
Article
in English
| MEDLINE
| ID: mdl-34334522
ABSTRACT
A palladium-mediated intramolecular aryl-aryl coupling reaction was applied to the total synthesis of the bioactive natural products, graphislactone G (1), and palmariols A (2) and B (3), which possess an unusual chloro-subsutituent on the 6H-dibenzo[b,d]pyran-6-one skeleton. Based on the transition state model of the coupling reaction, the mechanistic aspect for the regioselectivity of the aryl-aryl coupling reaction is also discussed.