ABSTRACT
To prove whether dietary intervention can prevent Helicobacter pylori-induced atrophic gastritis and gastric cancer, we developed cancer preventive kimchi (cpKimchi) through special recipe and administered to chronic H. pylori-initiated, high salt diet-promoted, gastric tumorigenesis mice model. H. pylori-infected C57BL/6 mice were administered with cpKimchi mixed in drinking water up to 36 weeks. Gross and pathological gastric lesions were evaluated after 24 and 36 weeks, respectively and explored underlying molecular changes to explain efficacies. Cancer preventive actions of anti-inflammation and anti-mutagenesis were compared between standard recipe kimchi (sKimchi) and special recipe cpKimchi in in vitro H. pylori-infected cell model. The erythematous and nodular changes, mucosal ulcerative and erosive lesions in the stomach were noted at 24th weeks, but cpKimchi administration significantly ameliorated. After 36th weeks, scattered nodular masses, some ulcers, and thin nodular gastric mucosa were noted in H. pylori-infected mice, whereas these gross lesions were significantly attenuated in cpKimchi group. On molecular analysis, significant expressions of COX-2 and IL-6, activated NF-κB and STAT3, increased apoptosis, and marked oxidative stresses were noted in H. pylori-infected group relevant to tumorigenesis, but these were all significantly attenuated in cpKimchi group. cpKimchi extracts imparted significant selective induction of apoptosis only in cancer cells, led to inhibition of H. pylori-induced proliferation, while no cytotoxicity through significant HO-1 induction in non-transformed gastric cells. In conclusion, daily dietary intake of cpKimchi can be an effective way either to rejuvenate H. pylori-atrophic gastritis or to prevent tumorigenesis supported with the concerted actions of anti-oxidative, anti-inflammatory, and anti-mutagenic mechanisms.
Subject(s)
Diet , Helicobacter Infections/drug therapy , Helicobacter pylori/drug effects , Plant Preparations/pharmacology , Stomach Neoplasms/prevention & control , Animals , Apoptosis/drug effects , Blotting, Western , Cell Line , Cell Line, Tumor , Cell Proliferation/drug effects , Cyclooxygenase 2/genetics , Cyclooxygenase 2/metabolism , Female , Gastric Mucosa/drug effects , Gastric Mucosa/metabolism , Gastric Mucosa/microbiology , Gastritis/complications , Gastritis/prevention & control , Gene Expression/drug effects , Helicobacter Infections/complications , Helicobacter Infections/microbiology , Helicobacter pylori/physiology , Heme Oxygenase-1/metabolism , Immunohistochemistry , Interleukin-6/genetics , Interleukin-6/metabolism , Medicine, Korean Traditional , Membrane Proteins/metabolism , Mice, Inbred C57BL , NF-kappa B/metabolism , Plant Preparations/administration & dosage , Plant Preparations/chemistry , Reverse Transcriptase Polymerase Chain Reaction , STAT3 Transcription Factor/metabolism , Stomach Neoplasms/complicationsABSTRACT
Vascular ectasia is a well-known cause of lower gastrointestinal bleeding in the elderly. Endoscopically, it usually appears as a flat or elevated bright red lesion. We report on an extremely rare case of a large, pedunculated, polypoid vascular ectasia in an asymptomatic patient. A large pedunculated polypoid mass in the sigmoid colon was observed on colonoscopy during a regular health check-up, and a polypectomy was performed using a detachable snare. In histology, vessels with massive dilation were found mainly in the submucosa, which was consistent with vascular ectasia.
