ABSTRACT
Men's sexual health can have significant effects on a man's self-esteem, sexual relationship and male reproductive functions. Although commercially available drugs (e.g., VIAGRA and CIALIS) show effective treatment of erectile dysfunction (ED), patients with severe ED fail to respond to these medicines. Topical nitric-oxide (NO) delivery to penis can be a painless, alternative solution with severe ED because NO triggers erection and diffuses to the trabecular arteries and smooth muscles in the penis. We here develop water-in-oil (W/O) nanoemulsions (NEs) that contain NO and can directly spread on the penis. We optimize NE formation conditions including hydrophilic-lipophilic balance (HLB) and ratio of oil, water and surfactants. Then, by spreading NEs on penis skin of intact middle aged dogs, we verify medication effects and safety of the NEs in vivo. The water-in-oil NEs can be a promising non-invasive medication for ED patients with low response to a phosphodiesterase type 5 (PDE5) inhibitor, thus increasing quality of life in the aging society.
ABSTRACT
A 12-year-old, spayed female Schnauzer presented with constipation. A mass was observed in the pelvic cavity, and metastasis was not identified. Mass resection was performed through celiotomy with pubic osteotomy, and hemangiosarcoma was diagnosed. At 10 weeks post-operatively, the patient died of multiple metastasis. Primary intrapelvic hemangiosarcoma is rare in dogs.
Subject(s)
Dog Diseases/surgery , Hemangiosarcoma/veterinary , Pelvic Neoplasms/veterinary , Animals , Dog Diseases/diagnosis , Dog Diseases/pathology , Dogs , Fatal Outcome , Female , Hemangiosarcoma/diagnosis , Hemangiosarcoma/pathology , Hemangiosarcoma/surgery , Pelvic Neoplasms/diagnosis , Pelvic Neoplasms/pathology , Pelvic Neoplasms/surgeryABSTRACT
A 10-year-old, Shih Tzu dog was presented with an enlarged, curled 2nd nail in the left forelimb. Digital amputation was performed and the mass was diagnosed as a nail bed keratoacanthoma (infundibular keratinizing acanthoma) histopathologically. There was no recurrence postoperatively. This is the first case report of a canine nail bed keratoacanthoma diagnosed by histologic and immunohistochemical examination including Ki-67 and p53 expression.
Kératocanthome d'un lit d'ongle canin diagnostiqué à l'aide d'une analyse immunohistochimique. Un chien Shih Tzu âgé de 10 ans a été présenté avec un deuxième ongle recourbé et hypertrophié sur la jambe avant gauche. Une amputation du doigt a été réalisée et la masse a été diagnostiquée en histopathologie comme un kératocanthome de lit d'ongle (acanthome kératinisant infundibulaire). Il n'y a pas eu de récurrence après l'opération. Il s'agit du premier rapport de kératocanthome de lit d'ongle canin diagnostiqué à l'aide d'un examen histologique et immunohistochimique incluant l'expression Ki-67 et p53.(Traduit par Isabelle Vallières).
