ABSTRACT
The new allele, A*11:251N, differs from A*11:01:01 by insertion of two nucleotides at position 204-205.
Subject(s)
Alleles , HLA-A Antigens/genetics , Base Pairing/genetics , Base Sequence , Exons/genetics , HumansABSTRACT
Three novel HLA alleles, HLA-A*26:118, DQB1*02:65 and DPB1*05:01:07, were identified and confirmed by monoallelic sequencing.
Subject(s)
Alleles , Asian People/genetics , HLA-A Antigens/genetics , HLA-DP beta-Chains/genetics , HLA-DQ beta-Chains/genetics , Base Sequence , Humans , Sequence AlignmentABSTRACT
The new allele HLA-C*03:03:35 showed one nucleotide difference with C*03:03:01:01 at position 408 (G>T).
Subject(s)
Alleles , HLA-C Antigens/genetics , Base Sequence , Exons/genetics , Genetic Loci , Histocompatibility Testing , Humans , Sequence AlignmentABSTRACT
HLA-DQB1*04:01:05 differs from DQB1*04:01:01 by a single nucleotide substitution at codon 30 (TAC>TAT).
Subject(s)
Alleles , Asian People/genetics , HLA-DQ beta-Chains/genetics , Base Sequence , Exons/genetics , Histocompatibility Testing , Humans , Sequence AlignmentABSTRACT
Four novel HLA alleles identified in Korean individuals and confirmed by monoallelic sequencing.
Subject(s)
Alleles , Asian People/genetics , HLA-B Antigens/genetics , HLA-DQ beta-Chains/genetics , HLA-DRB1 Chains/genetics , Amino Acid Sequence , Base Sequence , Exons/genetics , Histocompatibility Testing , HumansABSTRACT
The HLA-A*02:01:131 allele differs by a single nucleotide at codon 236 compared with HLA-A*02:01:01:01.
Subject(s)
Alleles , Anemia, Aplastic/genetics , Exons , HLA-A2 Antigen/genetics , Polymorphism, Single Nucleotide , Transplant Recipients , Anemia, Aplastic/immunology , Anemia, Aplastic/pathology , Anemia, Aplastic/therapy , Base Sequence , Codon/chemistry , Gene Expression , Genotype , HLA-A2 Antigen/immunology , Histocompatibility Testing , Humans , Peripheral Blood Stem Cell Transplantation , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The HLA-C*01:135 allele differs by a single nucleotide at codon 265 compared with HLA-C*01:02:01:01.
Subject(s)
Alleles , Exons , HLA-C Antigens/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Amino Acid Substitution , Base Sequence , Codon/chemistry , Gene Expression , Genotype , HLA-C Antigens/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The HLA-C*14:02:01:03 differs by a single nucleotide at intron 5 (2157 C>T) compared with C*14:02:01:01.
Subject(s)
Alleles , Exons , HLA-C Antigens/genetics , Polymorphism, Single Nucleotide , Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics , Transplant Recipients , Asian People , Base Sequence , Codon/chemistry , Gene Expression , Genotype , HLA-C Antigens/immunology , Histocompatibility Testing , Humans , Peripheral Blood Stem Cell Transplantation , Polymerase Chain Reaction , Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The HLA-C*02:02:33 allele differs by a single nucleotide at codon 215 compared with HLA-C*02:02:02:01.
Subject(s)
Alleles , Genomics/methods , HLA-C Antigens/genetics , Sequence Analysis, DNA/methods , Base Sequence , Exons/genetics , Histocompatibility Testing , Humans , Introns/geneticsABSTRACT
The new allele, A*24:313, showed one nucleotide difference with A*24:02:01 (595G>A).
Subject(s)
Alleles , HLA-A24 Antigen/genetics , HumansABSTRACT
New allele, B*15:367, differs from B*15:11:01 by a single nucleotide exchange at codon 222 (GAGâAAG).
Subject(s)
Asian People/genetics , HLA-B15 Antigen/isolation & purification , Aged , Amino Acid Substitution , Base Sequence , Exons/genetics , Female , HLA-B15 Antigen/genetics , Histocompatibility Testing , Humans , Molecular Sequence Data , Republic of Korea , Sequence Alignment , Sequence Analysis, DNA , Sequence Homology, Nucleic AcidABSTRACT
The HLA-C*15:02:01:03 allele differs from the HLA-C*15:02:01:01 allele by a single-nucleotide substitution in the 5' untranslated region (-42 C>A).
Subject(s)
Alleles , HLA-C Antigens/genetics , Leukemia/genetics , Polymorphism, Single Nucleotide , Base Sequence , Exons , Female , Genotype , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Leukemia/diagnosis , Leukemia/therapy , Male , Molecular Sequence Data , Polymerase Chain Reaction , Republic of Korea , Sequence Analysis, DNA , Tissue Donors , Transplant RecipientsABSTRACT
HLA-B*15:263 differs from HLA-B*15:18:01 by a single nucleotide exchange at position 824, C>G (codon 251 TCT>TGT).
Subject(s)
Alleles , Amino Acid Substitution , HLA-B15 Antigen/genetics , Hematopoietic Stem Cell Transplantation , Leukemia/genetics , Polymorphism, Single Nucleotide , Base Sequence , Codon , Exons , Gene Expression , HLA-B15 Antigen/immunology , Histocompatibility Testing , Humans , Leukemia/immunology , Leukemia/pathology , Leukemia/therapy , Male , Molecular Sequence Data , Republic of Korea , Sequence Alignment , Transplant RecipientsABSTRACT
The new allele, HLA-A*30:81, differs from A*30:01:01 by one nucleotide substitution at codon 272 (CTGâATG).
Subject(s)
Alleles , HLA-A Antigens/genetics , Female , Humans , Male , Sequence Analysis, DNAABSTRACT
The C*06:99 allele substitutes one nucleotide of C*06:02:01:01 at codon 50 (CCGâCTG), Pro to Leu.
Subject(s)
HLA-C Antigens/genetics , Histocompatibility Testing , Base Sequence , Exons/genetics , Gene Frequency , Genotype , Hematopoietic Stem Cell Transplantation , Humans , Korea , Molecular Sequence Data , Polymerase Chain Reaction , Sequence Alignment , Tissue DonorsABSTRACT
The new allele, HLA-C*03:04:36, differs from C*03:04:01:01 by one nucleotide substitution at codon 207 (GGCâGGT).
Subject(s)
Alleles , HLA-C Antigens/genetics , Histocompatibility Testing , Sequence Analysis, DNA , Base Sequence , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
The C*07:244 changes single nucleotide of C*07:02:01 at codon 75 (CGA â CAA), Arg to Gln.
Subject(s)
Alleles , HLA-C Antigens/genetics , Nucleotides/genetics , Amino Acid Substitution , Asian People , Base Sequence , Codon , Exons , Genetic Loci , HLA-C Antigens/immunology , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Analysis, DNA , Sequence Homology, Nucleic AcidABSTRACT
The new allele B*40:186 shows a one nucleotide substitution compared with B*40:01:02 at codon 56 (GGG â AGG) resulting in coding change, Gly to Arg.
Subject(s)
Alleles , HLA-B40 Antigen/genetics , Nucleotides/genetics , Amino Acid Substitution , Asian People , Base Sequence , Codon , Exons , Genetic Loci , HLA-B40 Antigen/immunology , Histocompatibility Testing , Humans , Introns , Molecular Sequence Data , Protein Isoforms/genetics , Protein Isoforms/immunology , Sequence Analysis, DNA , Sequence Homology, Nucleic AcidABSTRACT
The new allele A*02:07:02 shows a single nucleotide substitution compared with A*02:07:01 at codon 233 (ACC â ACT) without any amino acid change.
