ABSTRACT
Stewart-Treves syndrome (STS) is a rare cutaneous lymphangiosarcoma developing from chronic lymph edema as a consequence of radical mastectomy or surgical invasion of the groin for the treatment of cervical or penile cancer. Previous reports suggested possible mechanisms in the development of lymphangiosarcoma that correlate with the immunological background of STS patients. In this report, we described two cases of STS developing in patients who underwent radical dissection for cervical cancer, we employed immunohistochemical staining of IL-23 and IL-17.
ABSTRACT
Nivolumab plus ipilimumab combined therapy is one of the promising drugs that enhance the anti- immune response in patients with advanced melanoma. Therefore, to increase its response rate is of great interest to dermatologists. Recent reports suggested that, since CD8+ T cells after the administration of ICIs increase the RANKL expression to induce an immunosuppressive tumor microenvironment in melanoma, denosumab might enhance the anti-tumor effects of immune checkpoint inhibitors, such as nivolumab and ipilimumab. In this report, we present a case of multiple metastatic melanoma with nivolumab, ipilimumab plus denosumab combined therapy.
Subject(s)
Brain Neoplasms/secondary , CD8-Positive T-Lymphocytes/pathology , Dermatomyositis/diagnosis , Lymphoma, T-Cell, Cutaneous/pathology , Skin Neoplasms/pathology , Adolescent , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Biomarkers, Tumor/analysis , Biopsy , Brain Neoplasms/chemistry , Brain Neoplasms/immunology , Brain Neoplasms/therapy , CD8-Positive T-Lymphocytes/chemistry , CD8-Positive T-Lymphocytes/immunology , Cord Blood Stem Cell Transplantation , Cyclophosphamide/administration & dosage , Diagnosis, Differential , Doxorubicin/administration & dosage , Etoposide/administration & dosage , Humans , Lymphoma, T-Cell, Cutaneous/chemistry , Lymphoma, T-Cell, Cutaneous/immunology , Lymphoma, T-Cell, Cutaneous/therapy , Magnetic Resonance Imaging , Male , Predictive Value of Tests , Prednisone/administration & dosage , Skin Neoplasms/chemistry , Skin Neoplasms/immunology , Skin Neoplasms/therapy , Transplantation, Homologous , Treatment Outcome , Vincristine/administration & dosageABSTRACT
Sarcoidosis is occasionally accompanied by hematologic malignancies, including cutaneous T-cell lymphoma, called sarcoidosis-lymphoma syndrome. Although the mechanism underlying the induction of lymphomas is still unknown, understanding the immunological background of sarcoidosis could help explain the possible mechanisms of the induction of lymphomas. In this report, we describe a case of sarcoidosis-lymphoma syndrome associated with folliculotropic peripheral T cell lymphoma not otherwise specified, which caused dense infiltration of CD30+ CD163+ tumor-associated macrophages (TAMs) only in the lesional skin. Our present case might suggest the significance of TAMs in developing sarcoid-lymphoma syndrome.
