1.
Arch Virol
; 169(3): 47, 2024 Feb 16.
Article
in English
| MEDLINE
| ID: mdl-38366081
ABSTRACT
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis.
Subject(s)
Enzootic Bovine Leukosis , Leukemia Virus, Bovine , Animals , Female , Cattle , Proviruses/genetics , Leukemia Virus, Bovine/genetics
2.
J Med Virol
; 95(3): e28615, 2023 03.
Article
in English
| MEDLINE
| ID: mdl-36840401