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1.
Cytotoxicity of chloropeptide in isolated hepatocytes and its inactivation by microsomes.
Ueno, Y; Ito, T; Yoshizawa-Nakaki, H; Omata, Y; Ichiman, K.
J Toxicol Sci ; 7(2): 111-22, 1982 May.
Article in English | MEDLINE | ID: mdl-7131597

ABSTRACT

Chloropeptide, a hepatotoxic mycotoxin of Penicillium islandicum Sopp, induces gross changes in cell morphology including blebbing and ballooning of the cytoplasmic membrane in the isolated hepatocytes, and this hepatotoxic potential of chloropeptide is abolished by microsomal cytochrome P-450 system.


Subject(s)
Liver/drug effects , Microsomes, Liver/metabolism , Mycotoxins/toxicity , Peptides, Cyclic/toxicity , Animals , Aspartate Aminotransferases/analysis , Cell Survival/drug effects , Cytochrome P-450 Enzyme System/physiology , In Vitro Techniques , Inactivation, Metabolic , Liver/pathology , Male , Peptides, Cyclic/metabolism , Rats
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