ABSTRACT
Leukonychia refers to a white discoloration of the nails. Although several conditions may cause white nails, a rare, isolated, congenital form of the disease is hypothesized to stem from disordered keratinization of the nail plate. Herein, we report a case of a 41-year-old woman with congenital leukonychia and review prior cases.
Subject(s)
Hypopigmentation/congenital , Nail Diseases/congenital , Adult , Female , Humans , Hypopigmentation/diagnosis , Hypopigmentation/pathology , Nail Diseases/diagnosis , Nail Diseases/pathologySubject(s)
Dermatologic Agents/therapeutic use , Nervous System Diseases/etiology , Rosacea/physiopathology , Adolescent , Adult , Dermatologic Agents/pharmacology , Erythema/etiology , Face , Female , Hospitals, Teaching , Humans , Male , Middle Aged , Nervous System Diseases/drug therapy , Nervous System Diseases/physiopathology , Rosacea/drug therapy , Young AdultABSTRACT
Syringotropic cutaneous T-cell lymphoma (CTCL) is a rare form of CTCL characterized histologically by infiltrates of atypical lymphocytes located primarily in and around hyperplastic eccrine glands and ducts. Currently, syringotropic CTCL is classified as a histopathologic variant of folliculotropic mycosis fungoides (MF); however, the relationship between these two entities remains tenuous. We report two additional cases of syringotropic CTCL and review the differences between these two subtypes of MF with regard to epidemiology, clinical features, prognosis, and treatment. Based on these data, we conclude that syringotropic CTCL should be classified as a distinct variant of MF separate from folliculotropic MF.
