1.
Org Biomol Chem
; 8(21): 4819-22, 2010 Nov 07.
Article
in English
| MEDLINE
| ID: mdl-20859604
ABSTRACT
A rhodamine-based sensor RB-S2 was designed and synthesized by combination of the thiospirolacton chromophore and the thiophen ring block with high affinity to Hg(2+). Probe RB-S2 exhibits high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg(2+) in aqueous solution. In addition, fluorescent imaging of Hg(2+) in MCF-7 cells is also successfully demonstrated.
Subject(s)
Fluorescent Dyes/chemistry , Mercury/analysis , Rhodamines/chemistry , Thiophenes/chemistry , Cell Line, Tumor , Cell Survival , Humans , Microscopy, Fluorescence/methods , Sensitivity and Specificity , Spectrometry, Fluorescence/methods
2.
Org Lett
; 12(11): 2566-9, 2010 Jun 04.
Article
in English
| MEDLINE
| ID: mdl-20450147
ABSTRACT
A new pyrene-based derivative bearing an azadiene group was synthesized as a ratiometric chemosensor for Hg(2+) in aqueous acetonitrile solution. The "off-on" type signaling behavior of the fluoroionophore is due to the metal ion induced conformational changes from the weak pyrene monomer emissions to strong pyrene excimer emission.