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Efficient Synthesis of 5-Carboxy-2'-Deoxypyrimidine Nucleoside 5'-Triphosphates.
Gong, Shan-Shan; Sun, Jian; You, Yue-Hai; Chen, Ji-Zong; Liu, Guo-Dong; Sun, Qi.
Nucleosides Nucleotides Nucleic Acids ; 35(6): 295-304, 2016 Jun 02.
Article in English | MEDLINE | ID: mdl-27104859

ABSTRACT

An efficient P(V)-N activation method for the synthesis of 5-carboxy-2'-deoxyuridine and 5-carboxy-2'-deoxycytidine triphosphates directly from the corresponding phosphoropiperidate precursors has been developed.


Subject(s)
Uracil Nucleotides/chemical synthesis , Catalysis , Chromatography, High Pressure Liquid , Hydrogenation , Kinetics , Uracil Nucleotides/isolation & purification
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