ABSTRACT
AIM: To investigate the clinical value of 68Ga-FAPI-04 PET/CT for initial staging of esophageal cancer. METHODS: A total of 44 newly diagnosed patients with esophageal cancer were included in the analysis on the basis of postoperative pathology or clinical and radiologic follow-up. RESULTS: All primary lesions showed increased 68Ga-FAPI-04 uptake, with an SUVmax of 14.92 ± 6.91. A total of 561 lymph nodes were verified by surgery (507) or clinical and radiologic follow-up (54), of which 92 lymph nodes were diagnosed as showing metastases. Seventy-five lymph nodes with metastases showed positive findings on 68Ga-FAPI-04, with a diameter of about 1.06 ± 0.53 cm and SUVmax of 8.10±4.71. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for lymph node metastasis detection were 81.5%, 99.3%, 96.6%, 96.2%, and 96.5%, respectively. CONCLUSION: 68Ga-FAPI-04 PET/CT showed good diagnostic performance in detecting lymph node metastases of esophageal cancer.
Subject(s)
Esophageal Neoplasms , Positron Emission Tomography Computed Tomography , Humans , Radiopharmaceuticals , Fluorodeoxyglucose F18 , Esophageal Neoplasms/diagnostic imaging , Gallium RadioisotopesABSTRACT
ABSTRACT: A 67-year-old man with esophageal cancer was included in a clinical trial of a 68Ga-FAPI PET/CT study on tumors (ChiCTR2100044131). Increased tracer uptake was noted in the esophageal cancer with esophagitis. In addition, active coronary atherosclerotic plaque also revealed increased FAPI activity.
Subject(s)
Esophageal Neoplasms , Plaque, Atherosclerotic , Quinolines , Aged , Humans , Male , Plaque, Atherosclerotic/diagnostic imaging , Positron Emission Tomography Computed Tomography , Rare DiseasesABSTRACT
ABSTRACT: A 69-year-old man presented with newly diagnosed esophageal cancer was enrolled in our clinical trial of 68Ga-FAPI PET/CT study in tumors. Increased tracer uptake was noted in esophageal cancer. In addition, the facet joint osteoarthritis of T7/8 vertebrae also revealed elevated 68Ga-FAPI uptake.
Subject(s)
Esophageal Neoplasms , Osteoarthritis , Zygapophyseal Joint , Aged , Esophageal Neoplasms/complications , Esophageal Neoplasms/diagnostic imaging , Humans , Male , Positron Emission Tomography Computed Tomography , QuinolinesSubject(s)
Lymphoma, Large B-Cell, Diffuse , Thymoma , Thymus Neoplasms , Humans , Adult , Thymoma/diagnostic imaging , Gallium Radioisotopes , Positron Emission Tomography Computed Tomography , Thymus Neoplasms/diagnostic imaging , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Fluorodeoxyglucose F18ABSTRACT
ABSTRACT: A 69-year-old man presented with dysphagia for 6 months. Endoscopic biopsy showed no sign of malignancy, but enhanced chest CT revealed thickening of the esophageal wall, which was considered likely a potential malignancy. The patient subsequently was enrolled in our clinical trial of 68Ga-FAPI study in tumors. Intense 68Ga-FAPI activity was noted in the thickened esophagus. However, repeated endoscopic biopsies and relief of symptoms after drug treatment rendered a diagnosis of Candida albicans esophagitis.
Subject(s)
Esophageal Neoplasms , Esophagitis , Quinolines , Aged , Esophageal Neoplasms/diagnostic imaging , Humans , Male , Positron Emission Tomography Computed TomographyABSTRACT
ABSTRACT: A 39-year-old man was diagnosed clinically with hemophagocytic syndrome, which was suspected to be secondary to a malignancy. Therefore, the patient underwent a 68Ga-FAPI PET/CT scan as part of an ongoing clinical trial (ChiCTR2100044131). Increased tracer uptake was noted the gluteal region. Medical history revealed recent iliac bone marrow aspiration on the same side. On further examination, the lesion was confirmed to be a hematoma. The present case highlights that puncture operations may result in intramuscular hematomas, which might potentially malignancy on a 68Ga-FAPI PET/CT.
