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IET Syst Biol ; 5(5): 317-23, 2011 Sep.
Article in English | MEDLINE | ID: mdl-22010758

ABSTRACT

Based on the similarity between a reentrant wave in cardiac tissue and a vortex in fluid dynamics, the authors hypothesised that a new non-dimensional index, like the Reynolds number in fluid dynamics, may play a critical role in categorising reentrant wave dynamics. Therefore the goal of the present study is to devise a new index to characterise electric wave conduction in cardiac tissue and examined whether this index can be used as a biomarker for categorising the reentrant wave pattern in cardiac tissue. Similar to the procedure used to derive the Reynolds number in fluid dynamics, the authors used a non-dimensionalisation technique to obtain the new index. Its usefulness was verified using a two-dimensional simulation model of electrical wave propagation in cardiac tissue. The simulation results showed that electrical waves in cardiac tissue move into an unstable region when the index exceeds a threshold value.


Subject(s)
Heart Conduction System/physiology , Heart/physiology , Models, Cardiovascular , Action Potentials , Arrhythmias, Cardiac/physiopathology , Biomarkers/metabolism , Cardiology/methods , Computational Biology , Computer Simulation , Electrophysiology/methods , Humans , Models, Theoretical , Reference Standards , Rheology/methods , Systems Biology/methods
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