Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
RSC Adv ; 9(55): 32210-32218, 2019 Oct 07.
Article in English | MEDLINE | ID: mdl-35530773

ABSTRACT

An archazolid natural product fragment that displays dose-dependent inhibition of the vacuolar-type ATPase (VATPase) has been synthesized by a high-yielding Suzuki coupling of two complex subunits. Similarly, a further simplified fragment was prepared and evaluated for VATPase inhibitory activity. This compound did inhibit the VATPase, as evidenced by growth inhibition of etiolated Arabidopsis seedlings, however at approximately 10× lower potency than the more complex fragment. Cyclooxygenase (COX) enzyme inhibition was not observed for either fragment.

2.
RSC Adv ; 9(60): 34963, 2019 Oct 28.
Article in English | MEDLINE | ID: mdl-35532435

ABSTRACT

[This corrects the article DOI: 10.1039/C9RA07050H.].

3.
Synlett ; 28(9): 1101-1105, 2017 Jun.
Article in English | MEDLINE | ID: mdl-31592212

ABSTRACT

A convergent synthesis of a C1-C23 fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted Z,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.

SELECTION OF CITATIONS
SEARCH DETAIL
...