Assessing progress against the size of the problem.

To summarize articles with the depth and range of the nine in this collection is difficult. What the articles demonstrate as a whole is that a great deal of activity is under way in the arena of connecting child welfare and substance abuse services, with a growing body of documentation accompanying it. The articles bode good news in that they indicate a broadening awareness of the interconnectedness of these issues, and they highlight a number of creative and effective programs that have been established to mitigate the problems. Tremendous challenges-from funding to outcomes research-however, are also made evident in this body of work.

Mental health and substance abuse treatment services for dually diagnosed clients: results of a statewide survey of county administrators.

Finding are presented from a survey of administrators of county departments of mental health and alcohol and drug programs in California regarding services for individuals with co-occurring mental and substance abuse disorders. A total of 47 counties responded (84% response rate). The survey findings indicate that collaboration across county mental health and alcohol and drug services primarily occurs through information sharing, coordination of services, and joint projects. Fewer than one-half of the counties responding provide integrated programs, and the most frequently provided services are outpatient counseling and case management. Administrators cited historical differences between the two service systems and societal stigma as the greatest barriers to service delivery. Two opposing strategies for state action were suggested, either establishing specific funding set-asides or blending funding for services. Counties varied widely in their ability to estimate unmet service needs. Implications for policy development related to the dually diagnosed are discussed.

Effects of alcohol and other drugs on children.

Children are affected by alcohol and other drug use along three primary paths: in utero through the mother's use, environmentally through both family and community influences, and through their own use. Children who are prenatally exposed are put at risk both through physiological insults and through caregiving deficits in their immediate family. The number of cases of Fetal Alcohol Syndrome (FAS) in the western world has been estimated at 0.33 cases per 1,000 live births; 200 babies are born with FAS per year in California. The National Institute on Drug Abuse (NIDA) estimates that 7.62 million babies (18.6%) were exposed to alcohol during gestation. Current prevalence estimates show about 28.6 million children of alcoholics in the United States, while in California it is estimated that about 17.6% of children lived with a parent who used illegal substances during the past year. Although all the prenatal effects of alcohol are not known, it is clear that there is no safe amount of alcohol to be consumed during pregnancy. There is little consensus, however, on long-term effects from in utero exposure alone because of the influence of adverse environmental factors; prenatal exposure is usually not the final influence, but is reinforced by years of neglect, deprivation, negative behavioral models, and other adverse conditions. And although society places most emphasis upon the negative effects of illicit substances, use of alcohol is strongly associated with crime and family violence. The consequences of use of alcohol and tobacco are more costly to society in terms of health care, accidents, days of work lost, and other social costs.

Ultrastructural and x-ray analytical studies on intranuclear bismuth inclusions.

Parenteral administration of bismuth subnitrate produced intranuclear inclusions in the rabbit kidney tubules. In glutaraldehyde fixed material these inclusions had a homogeneous appearance but in osmicated material some of these inclusions showed a granular and fibrillar substructure. In relatively thick unstained sections prepared from unosmicated tissues, it was found that the inclusions were electron-dense, but they vanished from view when the electron beam was focussed on them. This phenomenon is thought to be due to the presence of bismuth, which is a mental with a high electrical resistance and low thermal conductivity. With the aid of electron-probe analysis the presence of bismuth was demonstrated in these inclusions and it seems possible that sulphur may be present here.