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1.
Am J Surg ; 226(1): 77-82, 2023 07.
Article in English | MEDLINE | ID: mdl-36858866

ABSTRACT

BACKGROUND: There is currently no consensus on surgical management of splenic flexure adenocarcinoma (SFA). METHODS: Patients undergoing surgical resection for SFA between 1993 and 2015 were identified. Postoperative outcomes were compared between patients who underwent segmental (SR) vs. anatomical resection (AR). RESULTS: One-hundred and thirteen patients underwent SR and 89 underwent AR. More patients in the SR group had open resections, but there were otherwise no differences in demographics or surgical characteristics between the two groups. There were no differences in overall (p = 0.29) or recurrence-free(p = 0.37) survival. On multivariable analysis, increased age (HR 1.04, 1.01-1.07, p = 0.005), higher American Society of Anesthesiology classification (HR 3.1, 1.7-5.71, p < 0.001), and higher tumor stage (HR 8.84, 3.76-20.82, p < 0.001) were predictive of mortality. CONCLUSIONS: Short and long-term outcomes after SR and AR for SFA are not different, making SR a viable option for SFA surgical management.


Subject(s)
Adenocarcinoma , Colon, Transverse , Colonic Neoplasms , Laparoscopy , Humans , Colon, Transverse/surgery , Treatment Outcome , Retrospective Studies , Colectomy , Adenocarcinoma/surgery , Adenocarcinoma/pathology
2.
Surg Endosc ; 33(11): 3833-3841, 2019 11.
Article in English | MEDLINE | ID: mdl-31451916

ABSTRACT

BACKGROUND: The benefits of enhanced recovery program (ERP) implementation include patient engagement, improved patient outcomes and satisfaction, better team relationships, lower per episode costs of care, lower public consumption of narcotic prescription pills, and the promise of greater access to quality surgical care. Despite these positive attributes, vast numbers of surgical patients are not treated on ERPs, and many of those considered "on pathway" are unlikely to be exposed to a majority of recommended ERP elements. METHODS: To explain the gap between ERP knowledge and action, this manuscript reviewed formal implementation strategies, proposed a novel change adoption model and focused on common barriers (and corollary solutions) that are encountered during the journey to a fully implemented and successful ERP. Given the nature of this review, IRB approval was not required/obtained. RESULTS: The information reviewed indicates that implementation of best practice is both a science and an art. What many surgeons have learned is that the "soft" skills of emotional intelligence, leadership, team dynamics, culture, buy-in, motivation, and sustainability are central to a successful ERP implementation. CONCLUSIONS: To lead teams toward achievement of pervasive and sustained adherence to best practices, surgeons need to learn new strategies, techniques, and skills.


Subject(s)
Enhanced Recovery After Surgery , General Surgery , Surgical Procedures, Operative/rehabilitation , Evidence-Based Practice , General Surgery/standards , General Surgery/trends , Humans , Quality Improvement
3.
N Engl J Med ; 380(5): 500-501, 2019 01 31.
Article in English | MEDLINE | ID: mdl-30699324
5.
Nat Rev Dis Primers ; 3: 17095, 2017 Dec 14.
Article in English | MEDLINE | ID: mdl-29239347

ABSTRACT

Chronic constipation is a prevalent condition that severely impacts the quality of life of those affected. Several types of primary chronic constipation, which show substantial overlap, have been described, including normal-transit constipation, rectal evacuation disorders and slow-transit constipation. Diagnosis of primary chronic constipation involves a multistep process initiated by the exclusion of 'alarm' features (for example, unintentional weight loss or rectal bleeding) that might indicate organic diseases (such as polyps or tumours) and a therapeutic trial with first-line treatments such as dietary changes, lifestyle modifications and over-the-counter laxatives. If symptoms do not improve, investigations to diagnose rectal evacuation disorders and slow-transit constipation are performed, such as digital rectal examination, anorectal structure and function testing (including the balloon expulsion test, anorectal manometry or defecography) or colonic transit tests (such as the radiopaque marker test, wireless motility capsule test, scintigraphy or colonic manometry). The mainstays of treatment are diet and lifestyle interventions, pharmacological therapy and, rarely, surgery. This Primer provides an introduction to the epidemiology, pathophysiological mechanisms, diagnosis, management and quality of life associated with the commonly encountered clinical problem of chronic constipation in adults unrelated to opioid abuse.


Subject(s)
Constipation/complications , Constipation/etiology , Prevalence , Age Factors , Constipation/physiopathology , Defecation , Defecography/methods , Digital Rectal Examination/methods , Humans , Laxatives/therapeutic use , Rectal Diseases/complications , Rectal Diseases/diagnosis , Rectum/abnormalities , Sex Factors
6.
JAMA Surg ; 152(5): 460, 2017 05 01.
Article in English | MEDLINE | ID: mdl-28122074
7.
Surg Endosc ; 29(5): 1071-9, 2015 May.
Article in English | MEDLINE | ID: mdl-25159636

ABSTRACT

BACKGROUND: Portomesenteric venous thrombosis (PMVT) is an uncommon complication of abdominal surgery. The objective of this study was to assess PMVT risk factor profiles and patient outcomes after colorectal surgery. METHODS: A single center retrospective review of patients undergoing colorectal surgery was performed (2007-2012). PMVT was defined as thrombus within the portal, splenic, or superior mesenteric vein on computed tomography (CT). Inferior mesenteric vein thrombosis was excluded. Independent samples t test was used to compare data variables between PMVT and non-PMVT patients. Univariate and multivariate logistic regression analyses were used to assess PMVT risk factors. RESULTS: There were 1,224 patients included (mean age 62 years, male = 566). Elective bowel resection was performed for colon carcinoma (n = 302), rectal carcinoma (n = 112), ulcerative colitis (n = 125), Crohn's disease (n = 78), polyps (n = 117), and diverticulitis (n = 215). Patients undergoing gynecological resections and emergent laparotomies were included (n = 275). Thirty-six patients (3%) were diagnosed with PMVT by CT: 17/36 on initial presentation and 19/36 by expert radiologist review. Patients with PMVT were younger (53 vs. 62 years, p = 0.001) with higher BMI (30.5 vs. 26.7, p < 0.001) and thrombocytosis (464 vs. 306, p < 0.001) compared to patients without PMVT. Univariate logistic regression identified younger age (p < 0.001), obesity (p < 0.001), ulcerative colitis (p < 0.001), thrombocytosis, (p < 0.001) and proctocolectomy as significant predictors of PMVT. Stepwise multivariate logistic regression identified that obesity (p < 0.001), thrombocytosis, (p < 0.001) and restorative proctocolectomy (p = 0.001) were still significant predictors. No patients in the PMVT group suffered bowel infarction and no related mortalities occurred. Thirty-day readmission rates were higher in the PMVT group (53% vs. 17%, p < 0.01). CONCLUSION: BMI ≥ 30 kg/m(2), thrombocytosis, and restorative proctocolectomy were significant predictors of PMVT. Initial diagnostic studies showed a PMVT rate of 1.4%; however, after expert focused radiologic review, the actual rate was 3%. Thus, the diagnosis of PMVT is difficult and readmission after colorectal surgery should prompt its consideration.


Subject(s)
Colonic Diseases/surgery , Colorectal Surgery/adverse effects , Mesenteric Veins , Portal Vein , Postoperative Complications/epidemiology , Rectal Diseases/surgery , Venous Thrombosis/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Incidence , Male , Middle Aged , Postoperative Complications/etiology , Retrospective Studies , Risk Factors , United States/epidemiology , Venous Thrombosis/etiology , Young Adult
8.
Dis Colon Rectum ; 57(8): 993-8, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25003294

ABSTRACT

BACKGROUND: Endoscopic surveillance of patients with ulcerative colitis aims to prevent cancer-related morbidity through the detection and treatment of dysplasia. The literature to date varies widely with regard to the importance of dysplasia as a marker for colorectal cancer at the time of colectomy. OBJECTIVE: The aim of this study was to accurately characterize the extent to which the preoperative detection of dysplasia is associated with undetected cancer in patients with ulcerative colitis. DESIGN/PATIENTS/SETTING: A retrospective chart review was conducted of patients undergoing surgery for colitis within the Mayo Clinic Health System between August 1993 and July 2012. MAIN OUTCOME MEASURES: Patient demographics and pre- and postoperative dysplasia were tabulated. The relationship between pre- and postoperative dysplasia/cancer in surgical pathology specimens was assessed. RESULTS: A total of 2130 patients underwent abdominal colectomy or proctocolectomy; 329 patients were identified (15%) as having at least 1 focus of dysplasia preoperatively. Of these 329 patients, the majority were male (69%) with a mean age of 49.7 years. Unsuspected cancer was found in 6 surgical specimens. Indeterminate dysplasia was not associated with cancer (0/50). Preoperative low-grade dysplasia was associated with a 2% (3/141) risk of undetected cancer when present in random surveillance biopsies and a 3% (2/79) risk if detected in endoscopically visible lesions. Similarly, 3% (1/33) of patients identified preoperatively with random surveillance biopsy high-grade dysplasia harbored undetected cancer. Unsuspected dysplasia was found in 62/1801 (3%) cases without preoperative dysplasia. LIMITATIONS: This study is limited by its retrospective nature and by its lack of evaluation of the natural history of dysplastic lesions that progress to cancer. CONCLUSIONS: The presence of dysplasia was associated with a low risk of unsuspected cancer at the time of colectomy. These findings will help inform the decision-making process for patients with ulcerative colitis who are considering intensive surveillance vs surgical intervention after a diagnosis of dysplasia.


Subject(s)
Colitis, Ulcerative/pathology , Colorectal Neoplasms/pathology , Precancerous Conditions/pathology , Aged , Biopsy , Cell Transformation, Neoplastic , Colitis, Ulcerative/surgery , Colonoscopy , Digestive System Surgical Procedures , Female , Humans , Male , Middle Aged , Retrospective Studies
9.
Cancer ; 120(16): 2472-81, 2014 Aug 15.
Article in English | MEDLINE | ID: mdl-24802276

ABSTRACT

BACKGROUND: Surgeon and hospital factors are associated with the survival of patients treated for rectal cancer. The relative contribution of each of these factors toward determining outcomes is poorly understood. METHODS: We used data from the Surveillance, Epidemiology, and End Results-Medicare database to analyze the outcomes of patients aged 65 years and older undergoing operative treatment for nonmetastatic rectal cancer, diagnosed in the United States between 1998 and 2007. These data were linked to a registry to identify whether the treating surgeon was a board-certified colorectal surgeon versus a noncolorectal surgeon. Hospital volume and hospital certification as a National Cancer Institute-designated Comprehensive Cancer Centers were also analyzed. The primary outcome of interest was long-term survival. RESULTS: Our data source yielded 6432 patients. Initial analysis demonstrated improved long-term survival in patients treated by higher-volume colorectal surgeons, higher-volume hospitals, teaching hospitals, and National Cancer Institute (NCI)-designated Comprehensive Cancer Centers. Based on an iterative approach to modeling the interactions between these various factors, we found a robust effect of surgeon subspecialty status, hospital volume, and NCI designation. Surgeon volume was not distinctly associated with long-term survival. CONCLUSIONS: Patients treated for rectal cancer by board-certified colorectal surgeons in centers that are higher volume and/or NCI-designated Comprehensive Cancer Centers experience better overall survival. These differences persist after adjustment for a broad range of patient and contextual risk factors, including surgeon volume. Patients and payers can use these results to identify surgeons and hospitals where outcomes are most favorable.


Subject(s)
Rectal Neoplasms/mortality , Rectal Neoplasms/surgery , Surgeons/standards , Aged , Cohort Studies , Female , Hospitals/standards , Hospitals/statistics & numerical data , Humans , Male , Outcome Assessment, Health Care , Rectal Neoplasms/pathology , SEER Program , Surgeons/statistics & numerical data , Survival Analysis , United States/epidemiology
10.
J Pediatr Surg ; 48(2): e33-6, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23414899

ABSTRACT

Tailgut cysts are uncommon lesions that usually occur within the presacral space. The relative rarity and nonspecific complaints associated with these lesions often lead to misdiagnosis or unnecessary procedures before the correct diagnosis is made. We describe a case of a 16-year-old female who presented with pelvic pain. She had previously undergone several procedures at an outside institution for recurrent perianal fistula and perirectal abscess. Subsequent evaluation under anesthesia revealed a presacral cystic mass with a well-developed tract within the anorectal ring in the posterior midline. This mass was surgically removed using a combined transanal and posterior sagittal excision technique and was found to be a tailgut cyst upon pathologic evaluation. Tailgut cysts and other presacral masses should be included in the differential for patients with recurrent abscess in the presacral space or fistula within the anal canal. A variety of surgical approaches are available depending on the anatomy of the lesion.


Subject(s)
Abscess/etiology , Cysts/complications , Cysts/diagnosis , Diagnostic Errors , Hamartoma/complications , Hamartoma/diagnosis , Rectal Diseases/complications , Rectal Diseases/diagnosis , Rectal Fistula/diagnosis , Rectal Fistula/etiology , Adolescent , Female , Humans , Pelvis , Recurrence
11.
Dis Colon Rectum ; 55(11): 1111-6, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23044670

ABSTRACT

BACKGROUND: Colonoscopy has an established role in reducing the burden of colorectal cancer through early detection and removal of polyps. For endoscopically unresectable polyps, colectomy is generally indicated to prevent malignant transformation or to remove cancer already present. OBJECTIVE: This study aimed to determine the incidence of malignancy and the factors predictive of malignancy in surgically resected benign polyps. DESIGN/PATIENTS/SETTING: This study was a retrospective chart review of patients undergoing a colectomy for a colonic polyp (no preoperative diagnosis of cancer) in 4 hospitals within the Mayo Clinic Health System. MAIN OUTCOME MEASURES: Patient characteristics, endoscopic location and size, and preoperative and operative polyp pathology were tabulated. Correlations between these features and the finding of invasive carcinoma on surgical pathology were assessed. RESULTS: A total of 750 patients met our inclusion criteria. Patients were predominantly male (55.2%) with an average age of 69.4 ± 9.8 years. A majority of polyps were located in the right colon (70.9%). Invasive cancer was identified in 133 patients (17.7%). Multivariate analysis revealed polyps in the left colon (adjusted OR 2.13, 95% CI (1.22-3.72)), and those with high-grade dysplasia (adjusted OR 4.60, 95% CI (2.91-7.27)) were more likely to harbor carcinoma. Age, sex, polyp dimension, and villous features were not predictive of malignancy. Of the patients with cancer, 31 (23.3%) had nodal disease. LIMITATIONS: This study is limited by its retrospective nature, the change in terminology and technique over time, and the partially subjective nature of an endoscopically unresectable polyp. CONCLUSIONS: The finding that polyp size and villous features do not strongly predict malignancy differs from previous endoscopic studies. This study confirms that polyps located in the left colon or with high-grade dysplasia are more likely to harbor cancer. The results of this study suggest that endoscopically unresectable polyps are best treated by radical oncologic resection.


Subject(s)
Adenoma/pathology , Carcinoma/pathology , Colonic Neoplasms/pathology , Colonic Polyps/pathology , Adenoma/surgery , Aged , Carcinoma/surgery , Colectomy , Colon, Descending/pathology , Colonic Neoplasms/surgery , Colonic Polyps/surgery , Colonoscopy , Confidence Intervals , Female , Humans , Male , Middle Aged , Multivariate Analysis , Neoplasm Grading , Neoplasm Invasiveness , Odds Ratio , Retrospective Studies , Risk Factors
12.
Int J Radiat Oncol Biol Phys ; 82(5): 1981-7, 2012 Apr 01.
Article in English | MEDLINE | ID: mdl-21477938

ABSTRACT

PURPOSE: We have previously shown that intensity-modulated radiotherapy (IMRT) can reduce dose to small bowel, bladder, and bone marrow compared with three-field conventional radiotherapy (CRT) technique in the treatment of rectal cancer. The purpose of this study was to review our experience using IMRT to treat rectal cancer and report patient clinical outcomes. METHODS AND MATERIALS: A retrospective review was conducted of patients with rectal cancer who were treated at Mayo Clinic Arizona with pelvic radiotherapy (RT). Data regarding patient and tumor characteristics, treatment, acute toxicity according to the Common Terminology Criteria for Adverse Events v 3.0, tumor response, and perioperative morbidity were collected. RESULTS: From 2004 to August 2009, 92 consecutive patients were treated. Sixty-one (66%) patients were treated with CRT, and 31 (34%) patients were treated with IMRT. All but 2 patients received concurrent chemotherapy. There was no significant difference in median dose (50.4 Gy, CRT; 50 Gy, IMRT), preoperative vs. postoperative treatment, type of concurrent chemotherapy, or history of previous pelvic RT between the CRT and IMRT patient groups. Patients who received IMRT had significantly less gastrointestinal (GI) toxicity. Sixty-two percent of patients undergoing CRT experienced ≥Grade 2 acute GI side effects, compared with 32% among IMRT patients (p = 0.006). The reduction in overall GI toxicity was attributable to fewer symptoms from the lower GI tract. Among CRT patients, ≥Grade 2 diarrhea and enteritis was experienced among 48% and 30% of patients, respectively, compared with 23% (p = 0.02) and 10% (p = 0.015) among IMRT patients. There was no significant difference in hematologic or genitourinary acute toxicity between groups. In addition, pathologic complete response rates and postoperative morbidity between treatment groups did not differ significantly. CONCLUSIONS: In the management of rectal cancer, IMRT is associated with a clinically significant reduction in lower GI toxicity compared with CRT. Further study is needed to evaluate differences in late toxicity and long-term efficacy.


Subject(s)
Adenocarcinoma/radiotherapy , Intestines/radiation effects , Radiation Injuries/complications , Radiotherapy, Intensity-Modulated/adverse effects , Rectal Neoplasms/radiotherapy , Urinary Bladder/radiation effects , Adenocarcinoma/drug therapy , Adenocarcinoma/surgery , Adult , Aged , Aged, 80 and over , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Chemoradiotherapy/methods , Diarrhea/etiology , Enteritis/etiology , Female , Humans , Male , Middle Aged , Preoperative Period , Radiotherapy Dosage , Radiotherapy, Conformal/adverse effects , Radiotherapy, Conformal/methods , Radiotherapy, Intensity-Modulated/methods , Rectal Neoplasms/drug therapy , Rectal Neoplasms/surgery , Retrospective Studies
13.
Ann Surg ; 255(1): 66-9, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22104563

ABSTRACT

OBJECTIVE: The aim of this study was to compare single-incision laparoscopic colectomy (SILC) to multiport laparoscopic colectomy (MLC) when performed by experienced laparoscopic surgeons. BACKGROUND: Recent case reports and single institution series have demonstrated the feasibility of SILC. Few comparative studies for MLC and SILC have been reported. METHODS: Patients from 5 institutions undergoing SILC were entered into an IRB approved database from November 2008 to March 2010. SILC patients were matched with those undergoing MLC for gender, age, disease, surgery, BMI, and surgeon. The primary endpoint was length of stay and secondary endpoints included operative time, conversion, complications and postoperative pain scores. RESULTS: Three hundred thirty patients (SILC = 165, MLC = 165) were evaluated. Operative time (135 ± 45 min vs. 133 ± 56 min; P = 0.85) and length of stay (4.6 ± 1.6 vs. 4.3 ± 1.4; P = 0.35) were not significantly different. Maximum postoperative day one pain scores were significantly less for SILC (4.9 vs. 5.6; P = 0.005). Eighteen (11%) patients undergoing SILC were converted to multiport laparoscopy. There was no statistical difference between groups for conversions to laparotomy, complications, re-operations, or re-admissions. CONCLUSIONS: SILC is feasible when performed on select patients by surgeons with extensive laparoscopic experience. Outcomes were similar to MLC, except for a reduction in peak pain score on the first postoperative day. Prospective randomized trials should be performed before incorporation of this technology into routine surgical care.


Subject(s)
Colectomy/methods , Colonic Diseases/surgery , Colonic Neoplasms/surgery , Colonic Polyps/surgery , Laparoscopy/methods , Adolescent , Adult , Aged , Aged, 80 and over , Case-Control Studies , Colitis, Ulcerative/surgery , Crohn Disease/surgery , Diverticulitis, Colonic/surgery , Feasibility Studies , Female , Gastrointestinal Hemorrhage/surgery , Humans , Length of Stay , Male , Middle Aged , Pain, Postoperative/etiology , Postoperative Complications/etiology , Young Adult
14.
World J Surg ; 35(7): 1505-14, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21476115

ABSTRACT

Minimally invasive techniques have had a marked impact on colorectal surgery despite the limited adoption of such techniques. Patients stay in the hospital a shorter time, experience less pain, and have less chance of developing a wound infection, an incisional hernia, a bowel obstruction, or difficulty becoming pregnant. Training courses have undergone metamorphosis from ad hoc animate courses to highly defined educational opportunities, and fellowships have had to respond to the educational demands of trainees demanding to be exposed to minimally invasive techniques.


Subject(s)
Colectomy/methods , Colorectal Surgery/methods , Biomedical Research , Colectomy/education , Colectomy/trends , Colorectal Surgery/education , Colorectal Surgery/trends , Female , Forecasting , Humans , Minimally Invasive Surgical Procedures , Time Factors , Treatment Outcome
15.
World J Surg ; 33(5): 1049-52, 2009 May.
Article in English | MEDLINE | ID: mdl-19277774

ABSTRACT

BACKGROUND: The aim of the present study was to examine the early outcome in patients undergoing intestinal resection for Crohn's disease (CD) while they are receiving perioperative immunosuppressive medication. METHODS: We reviewed patients with CD undergoing intestinal surgery from 1999 to 2007. Demographics and relevant perioperative information, including medication, were extracted from patient charts. Statistical analysis was performed using Fisher's exact test. RESULTS: During the course of the study period 112 with Crohn's disease underwent intestinal resection, and 69 of them were receiving perioperative medication (47, corticosteroids; 39, immunomodulators; and 17, anti-tumor necrosis factor-alpha antibodies). There were no deaths. Median blood loss was 137 ml. Twenty-two of the patients using perioperative medication (32%) experienced complications, 10 of which were major. The major complications occurred in 3 of the 43 patients (7%) who were not receiving perioperative medications, in 5 of 38 patients (13%) who were receiving one drug, 4 of 28 patients (14%) receiving two drugs, and 1 of 3 patients (33%) receiving three drugs. Thus the occurrence of major complications was not significantly greater in patients receiving perioperative medication. Risk factors for a major complication were intraoperative blood loss >400 ml (P < 0.003) and emergency surgery (P < 0.005). CONCLUSIONS: The occurrence of complications in Crohn's disease patients undergoing intestinal resection was not associated with the use of immunosuppressive medication. However, emergency surgery and blood loss were risk factors, and reflect the difficulty of surgery in this group of patients.


Subject(s)
Crohn Disease/surgery , Digestive System Surgical Procedures/adverse effects , Immunosuppressive Agents/therapeutic use , Perioperative Care/methods , Adrenal Cortex Hormones/therapeutic use , Adult , Aged , Aged, 80 and over , Antibodies, Monoclonal/therapeutic use , Combined Modality Therapy , Crohn Disease/drug therapy , Drug Therapy, Combination , Female , Humans , Immunologic Factors/therapeutic use , Male , Middle Aged , Postoperative Complications , Retrospective Studies , Risk Factors , Treatment Outcome , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Young Adult
17.
Surg Endosc ; 23(8): 1876-81, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19184211

ABSTRACT

BACKGROUND: Outcomes of laparoscopic resection for ileocecal Crohn's disease have been reported previously in smaller studies, suggesting its short-term advantages over open surgery. This study assessed the safety and recovery parameters in the largest, consecutive, single-institution series to date. METHODS: Consecutive patients undergoing laparoscopically assisted primary ileocolic resection for Crohn's disease between 1994 and 2006 were identified in an institutional prospectively collected database. Operative and postoperative outcomes at 30 days were studied. RESULTS: In this study, 109 patients (35 men) with a mean age of 35 +/- 14 years and a mean body mass index (BMI) of 25 +/- 6 kg/m(2) were identified. The main indications for surgery were medically refractory disease (63%) and fibrous stenosis (27%). In 41% of the cases, previous abdominal surgery had been performed. The surgery had a mean duration of 150 +/- 45 min and a conversion rate of 6%. The overall 30-day morbidity rate was 11%, and the reoperation rate was 1%. The mortality rate was 0%. The median postoperative hospital stay was 4 days (range, 2-15 days). CONCLUSIONS: This series, the largest reported to date, concurs with recent metaanalyses findings that laparoscopically assisted primary ileocecal resection for Crohn's disease is safe and feasible, resulting in better short-terms outcomes than open resection. This operation is therefore the procedure of choice for Crohn's disease at our institutions.


Subject(s)
Colectomy/methods , Crohn Disease/surgery , Ileum/surgery , Laparoscopy/methods , Abdominal Abscess/etiology , Abdominal Abscess/surgery , Adult , Anti-Inflammatory Agents/therapeutic use , Combined Modality Therapy , Crohn Disease/complications , Crohn Disease/drug therapy , Crohn Disease/rehabilitation , Feasibility Studies , Female , Humans , Immunosuppressive Agents/therapeutic use , Intestinal Fistula/etiology , Intestinal Fistula/surgery , Intestinal Obstruction/etiology , Intestinal Obstruction/surgery , Laparoscopy/statistics & numerical data , Male , Postoperative Complications/epidemiology , Reoperation , Treatment Outcome
18.
Surg Endosc ; 23(1): 174-7, 2009 Jan.
Article in English | MEDLINE | ID: mdl-18855064

ABSTRACT

BACKGROUND: Postoperative adhesions are an expected outcome for the majority of open abdominal operations, occurring in more than 90% of cases. Adhesions are responsible for more than 75% of small bowel obstruction cases. This study aimed to evaluate adhesions to the anterior abdominal wall and adnexal organs after laparoscopic ileal-pouch anal anastomosis (IPAA). METHODS: Patients who underwent laparoscopic IPAA for ulcerative colitis had laparoscopic evaluation of adhesions at loop ileostomy closure for assessment of adhesions to the anterior abdominal wall and for adhesions to the adnexae in the case of women. Adhesions to the adnexae were quantified using the American Fertility Society adhesion score. Data were maintained prospectively. RESULTS: In this study, 34 patients (21 women) ranging in age from 19 to 78 years (median, 36 years) underwent laparoscopic IPAA. With regard to anterior abdominal wall adhesions, 23 patients (68%) had no adhesions to the anterior abdominal wall, and the remaining 11 patients had few adhesions (filmy, avascular). No patients had dense adhesions to the abdominal wall. Of the 21 women, 15 (71%) had no adnexal adhesions, 5 had filmy adhesions enclosing less than one-third one adnexa, and 1 had filmy adhesions enclosing one-third to two-thirds of one adnexa. No patient had adhesions affecting both adnexae. CONCLUSIONS: Laparoscopic IPAA results in few adhesions to the anterior abdominal wall or to gynecologic organs. These adhesions were significantly fewer than previously reported for open operations with or without the use of a glycerol hyaluronate/carboxymethylcellulose bioresorbable (GHA/CMC) adhesion barrier.


Subject(s)
Adnexal Diseases/epidemiology , Colitis, Ulcerative/surgery , Colonic Pouches , Laparoscopy , Peritoneal Diseases/epidemiology , Proctocolectomy, Restorative , Adnexal Diseases/pathology , Adult , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Peritoneal Diseases/pathology , Retrospective Studies , Tissue Adhesions/epidemiology , Tissue Adhesions/pathology , Young Adult
19.
Ann Surg ; 248(5): 746-50, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18948801

ABSTRACT

OBJECTIVE: To test the hypothesis that surgeon volume would not predict short- and long-term outcomes when evaluated in the setting of technical credentialing. SUMMARY BACKGROUND DATA: Surgical volume is a known predictor of outcomes; the importance of technical credentialing has not been evaluated. METHODS: Fifty-three credentialed surgeons operated on 871 patients in the Clinical Outcomes of Surgical Therapy Study (NCT00002575), investigating laparoscopic versus open surgery for colon cancer. Credentialing required that each surgeon document performance of at least 20 laparoscopic colon cases and demonstrate oncologic techniques on a video-recorded case. Surgeons were separated based on volume entered into the trial (low, < or =5 cases (n = 39); medium, 6-10 cases (n = 9); or high, >10 cases (n = 5)) and compared by outcomes. RESULTS: Patients treated by high volume compared with medium or low volume surgeons were older (70, 66, and 68 years; P < 0.001), more often had right-sided tumors (63%, 46%, and 53%; P < 0.001) and had more previous operations (48%, 38% and 45%; P < 0.004), respectively. Mean operative times were shorter (123, 147 and 145 minutes; P < 0.001), distal margins longer (13.4, 12.4 and 11.6 cm; P = 0.005), and lymph node harvest greater (14.8, 12.8, 12.6; P = 0.05) for high versus medium versus low volume surgeons. However, rates of conversion, complications, 5-year survival, and disease-free survival showed no significant differences. CONCLUSION: When tested in a randomized controlled trial with case-specific surgical technical credentialing and auditing, surgeon volume did not predict differences in rates of conversion, complications, or long-term cancer outcomes. Case-specific technical credentialing should be further studied specific to the role it could play in creating consistent, high quality outcomes.


Subject(s)
Clinical Competence , Colectomy/standards , Colonic Neoplasms/surgery , Credentialing , Laparoscopy/standards , Aged , Colectomy/statistics & numerical data , Colonic Neoplasms/mortality , Colorectal Surgery/standards , Colorectal Surgery/statistics & numerical data , Disease-Free Survival , Female , Forecasting , Humans , Kaplan-Meier Estimate , Laparoscopy/statistics & numerical data , Male , Middle Aged , Randomized Controlled Trials as Topic , Treatment Outcome
20.
Dis Colon Rectum ; 51(4): 392-6, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18213489

ABSTRACT

PURPOSE: This study was designed to compare self-reported sexual function, body image, and quality of life outcomes among ulcerative colitis patients undergoing laparoscopic or open ileal pouch-anal anastomosis. METHODS: Between 1978 and 2004, 100 laparoscopic and 189 open operations were performed in patients who were identified from a previously published cohort. Patients were surveyed one year after operation to evaluate sexual function, body image, and quality of life. RESULTS: A total of 125 of 289 patients (43 percent) returned completed surveys. There were no significant differences in terms of demographics, complications, or long-term functional outcomes between those who completed the surveys and those who did not. There were no clinical differences in results between laparoscopic and open patients using the three survey instruments. Orgasmic function scores were lower in men who underwent laparoscopic ileal pouch-anal anastomosis (P < 0.05) compared with open ileal pouch-anal anastomosis. Overall, sexual function scores were equal to or better than normal values for men but were lower in women. Finally, overall body image and quality of life scores were above the means published for the United States. CONCLUSIONS: After ileal pouch-anal anastomosis, men and women reported excellent body image and high cosmetic and quality of life scores regardless of operative approach. Female sexual function was more adversely affected after ileal pouch-anal anastomosis than was male sexual function.


Subject(s)
Anal Canal/surgery , Body Image , Colonic Pouches , Laparoscopy/psychology , Quality of Life , Sexuality/physiology , Adenomatous Polyposis Coli/surgery , Adult , Anastomosis, Surgical/methods , Anastomosis, Surgical/psychology , Colitis, Ulcerative/surgery , Female , Follow-Up Studies , Humans , Laparoscopy/methods , Male , Postoperative Period , Retrospective Studies , Surveys and Questionnaires , Treatment Outcome
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