Multiple ruptured cerebral aneurysms at the National Hospital of the Kyrgyz Republic between 2008 and 2014: a departmental summary.

Despite the rapid progress of vascular neurosurgery with the development of microsurgical and endovascular techniques, the optimal strategy for surgical treatment of multiple cerebral aneurysms has not yet been developed. The indications for choosing one-stage or multi-stage surgery remain unsolved. This is a summary of the departmental routine reports at the Clinic of Neurosurgery, National Hospital of the Kyrgyz Republic. Subjects were 235 patients (124 males and 111 females) with ruptured multiple cerebral aneurysms admitted to the hospital. Their ages ranged from 18 to 72 years (average and standard deviation: 44.3 ± 9.7 years) and 48.1% of patients had 3 or more aneurysms. Among aneurysms that ruptured, 20.4% were a giant aneurysm (>25 mm) and 43.0% of patients had grade IV or V according to the Hunt-Hess Scale. Among 228 patients who were operated on, 147 were treated by single-stage surgery and 81 by multi-stage surgery. Microsurgical operations with clipping of the aneurysm neck were performed in 141 (61.8%) patients (97 single-stage and 44 multi-stage), while 40 (17.5%) patients (16 single-stage and 24 multi-stage) were operated using the endovascular technique. The number of palliative surgeries (trapping, ligation of the internal carotid artery, and reinforcement of the aneurysm wall) was significantly less (p=0.011) with multi-stage surgery (9 out of 81 cases, 11.1%) than with single-stage surgery (38 out of 147 cases, 25.9%). Among 600 aneurysms, 583 (97.2%) were treated by either single-stage surgery (n=296) or multi-stage surgery (n=287). There were no differences in prognosis at discharge between single-stage and multi-stage surgery.

Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan.

Vitamin K deficiency bleeding (VKDB) is a preventable cause of infant mortality and long-term morbidity through the world. This study aimed to demonstrate the costs of VKDB treatment estimated from the hospital records in Tashkent, Uzbekistan, as well as the prophylaxis costs for mass vitamin K medication. Subjects were 50 patients with no operation and 50 patients who had received a brain operation, consecutively enrolled from 180 cases diagnosed at Republican Research Center of Emergency Medicine in 2014. In that year, an additional 22 VKDB patients were found in Tashkent; the incidence of VKDB was 478/100,000 among 42,225 newborns. The prophylaxis costs for all newborns in Tashkent were estimated under a plausible condition. The average age at admission was 43.2 days among 100 patients (67 boys and 33 girls) with birth weight from 2,600 g to 3,800 g (3,105 g on average). The great majority of patients (92.0%) were breastfed; 89.5% in boys and 97.0% in girls. Average treatment cost per VKDB patient was 365 USD for the operated and 285 USD for the non-operated. Total expenses of the 202 patients were estimated to be 64,603 USD. A single prophylaxis was estimated to cost 1.24 USD, totaling 52,359 USD for the prophylaxis of 42,225 newborns. Since the reduction of VKDB incidence through prophylaxis is considered to be higher than 78.5% (52,359/64,603), provision of prophylaxis services would reduce the total costs of VKDB treatment in Uzbekistan, where prophylaxis is not provided.