Variability of the accommodation response in early onset myopia.

PURPOSE: Hyperopic retinal defocus (blur) is thought to be a cause of myopia. If the retinal image of an object is not clearly focused, the resulting blur is thought to cause the continuing lengthening of the eyeball during development causing a permanent refractive error. Both lag of accommodation, especially for near targets, and greater variability in the accommodative response, have been suggested as causes of increased hyperopic retinal blur. Previous studies of lag of accommodation show variable findings. In comparison, greater variability in the accommodative response has been demonstrated in adults with late onset myopia but has not been tested in children. This study looked at the lag and variability of accommodation in children with early onset myopia. METHODS: Twenty-one myopic and 18 emmetropic children were tested. Dynamic measures of accommodation and pupil size were made using eccentric photorefraction (PowerRefractor) while children viewed targets set at three different accommodative demands (0.25, 2, and 4 D). RESULTS: We found no difference in accommodative lag between groups. However, the accommodative response was more variable in the myopes than emmetropes when viewing both the near (4 D) and far (0.25 D) targets. Since pupil size and variability also varied, we analyzed the data to determine whether this could account for the inter-group differences in accommodation variability. Variation in these factors was not found to be sufficient to explain these differences. Changes in the accommodative response variability with target distance were similar to patterns reported previously in adult emmetropes and late onset myopes. CONCLUSIONS: Children with early onset myopia demonstrate greater accommodative variability than emmetropic children, and have similar patterns of response to adult late onset myopes. This increased variability could result in an increase in retinal blur for both near and far targets. The role of accommodative variability in the etiology of myopia is discussed.

Short-term adaptation of the human corneal endothelium to continuous wear of silicone hydrogel (lotrafilcon A) contact lenses after daily hydrogel lens wear.

PURPOSE: The purpose of this study is to assess whether improved oxygen availability to the cornea resulted in changes in the corneal endothelium. METHODS: Eighteen adult (average age 25.3 +/- 5.1 years) hydrogel lens wearers (average of 5.5 years prior daily lens wear, range 3-9 years) were refitted with silicone hydrogel lenses (Focus Night and Day) for continuous wear over 30 days and nights. They were assessed in detail immediately before the refit (baseline measures) and again after 6 months of wear with lens replacement every 30 days. Assessments included slit biomicroscopy (for grading of limbal and bulbar redness), corneal staining with fluorescein, and then by noncontact specular microscopy for central corneal thickness (CCT) and endothelial cell layer images. The endothelial images exported as JPEG files and printed at 7000x magnification. The cell-cell borders were marked and then the areas of an average of 255 cells/image measured with a digitizer pad in stream mode. The number of cell sides was also counted. RESULTS: After 6 months of silicone hydrogel lens wear, most subjects showed an improvement in mean bulbar (1.1 to 0.9) and limbal redness (1.0 to 0.6, p < 0.001) and epithelial fluorescein staining (0.5 to 0.3) grades, and the mean CCT values decreased slightly in most subjects (0.527 to 0.520 mm), although the decrease was not statistically significant (p = 0.565). The mean endothelial cell area also increased slightly (358 to 363 microm2; p nonsignificant [NS] = 0.701), whereas the mean coefficient of variation (COV) decreased slightly (30.2 to 29.1%, p NS = 0.357). The calculated mean endothelial cell density (ECD; area/1000000 microm2) also decreased slightly from 2821 to 2774 cells/mm, but this change also was not statistically significant (p = 0.620). However, the changes in ECD showed a very substantial relationship to the changes in CCT, i.e., as CCT decreased, so the apparent ECD decreased; this change was highly significant (r = 0.747, p < 0.001). This relationship was slightly stronger still when possible image magnification differences were corrected for. The percentage of six-sided ("hexagonal") cells increased slightly (58.3 to 60.1%). CONCLUSION: The results indicate that, in silicone hydrogel lens wearers exhibiting positive external eye signs thought to be associated with improved oxygen availability, subtle morphologic changes (marginally decreased polymegethism and pleomorphism) in the central region of the corneal endothelium can occur. It remains to be established, however, whether these changes can be directly attributed to oxygen effects (reduced hypoxia and hypercapnia altering the endothelial cells) or to a mechanical effect (in which changes in corneal thickness result in a reorganization of the corneal endothelium).

A 6-month follow-up of successful refits from daily disposable soft contact lenses to continuous wear of high-Dk silicone-hydrogel lenses.

PURPOSE: To compare, in routine optometric practice, the outcome of keeping successful soft contact lens (SCL) wearers in their lenses to re-fitting them with continuous wear of silicone hydrogel (SiH) lenses. METHODS: Forty-nine successful daily disposable lens wearers were recruited; 19 continued to wear daily SCLs and 30 were refitted with high-Dk SiH lenses on a 30-day/night schedule. Patients were assessed at baseline, 3 and 6 months by slit lamp examination along with the Efron grading scales, and central corneal thickness (CCT) and the corneal endothelium were assessed by non-contact specular microscopy. RESULTS: No substantial changes in subjective vision, refraction, visual acuity or overall lens comfort occurred for those completing the study, although five SiH lens wearers did discontinue due to reduced comfort, eyelid problems or seasonal allergy. Contact lens induced peripheral ulcers (CLPU) were observed in three patients in the first 3 months in the SiH lens group and these were also discontinued. Over the 6 month period, a complete set of records was obtained for 16 in each group. For those completing the study, lens dryness scores were variable, but there was a slight improvement in favour of SiH lenses. Small, but statistically significant, reductions in corneal staining, bulbar hyperaemia, and limbal neovascularisation in favour of the SiH lenses were also evident but mainly because of further increases in the daily lens wearers. Contact lens induced papillary conjunctivitis (CLPC) and corneal endothelial polymegethism were mild to moderate and showed slight increases in the daily lens wearers at 6 months. CONCLUSIONS: The present studies confirm that the continuous wear of SiH lenses for up to 30 days can be considered as an alternative to daily disposable soft lens wear, but is not suitable for everyone.