Effects of Rehabilitation Therapy at Different Intervention Times on Daily Living Activity and Motor Function in Patients with Traumatic Spinal Cord Injury.

Objectives: We investigated the impact of traumatic spinal cord injury (TSCI) on daily living activities and motor function of TSCI patients. Methods: A total of 88 TSCI patients were randomly divided into Group A (N=44) and Group B (N=44). Group A received rehabilitation treatment 7 days after the stabilization of vital signs, and Group B received rehabilitation treatment 30 days after hospitalization. Results: The compliance rate of Group A (93.18%) was higher than that of Group B (72.73%) (χ 2 =6.510, p<.05); The scores of American Spinal Injury Association (ASIA) and Activities of Daily Living (ADL) in Group A were higher than those in Group B. The self-rating score of anxiety and depression was lower than that of Group B (p<.05). Conclusion: For the rehabilitation treatment of TSCI patients, it is better to choose the intervention after the vital signs are stable to improve patients' ability for daily living activities and motor function.

Synthesis of Vanadium Doped Lanthanum Bismuthate Nanorods for Enhanced Photocatalytic Activity.

Vanadium doped lanthanum bismuthate nanorods with vanadium ratio of 1%, 3%, 5% and 10 wt.% were fabricated through the hydrothermal method using sodium orthovanadate as vanadium source. Vanadium doped lanthanum bismuthate nanorod products were analyzed by scanning electron microscopy, X-ray diffraction pattern and diffuse reflection spectrum. X-ray diffraction patterns show that vanadium in the vanadium doped lanthanum bismuthate nanorods exists as triclinic Bi23V4O44.5 and monoclinic LaVO4 phases. Scanning electron microscopy observations show that the size and micro-morphology of the vanadium doped products are closely relative to the vanadium mass ratio. The length of the vanadium doped nanorods decreases and the morphology changes from nanorods to irregular nanoparticles with increasing the vanadium mass ratio. Solid UV-vis diffuse reflectance measurement shows that the bandgap value of the doped lanthanum bismuthate nanorods is narrowed from 2.37 eV to 2.25 eV after the vanadium doping ratio is increased from 1% to 10%. The doped lanthanum bismuthate nanorods illustrate enhanced photocatalytic performance for methylene orange (MO) removal with the irradiation of sunlight. The catalytic performance for MO removal depends on the irradiation time, vanadium content and dosage of the nanorods. The doped lanthanum bismuthate nanorods with the vanadium mass ratio of 10% possess the best MO catalytic degradation performance.

A Review on Ternary Bismuthate Nanoscale Materials.

BACKGROUND: Bismuth-containing nanoscale materials exhibit great application potential in catalysts, optical devices, electron devices, photo-electric devices and sensors owing to their good catalytic, optical, electric, photoelectric and sensing performance. Special research interest has been devoted to ternary bismuthate nanoscale materials due to their special layered structure, large specific surface area, excellent optical, catalytic, electrical and electrochemical performance. Therefore, it is essential to synthesize novel ternary bismuthate nanoscale materials for practical application. METHODS: The article reviews the recent progress and patents on the ternary bismuthate nanoscale materials. The recent progress and patents on the synthesis and application of the ternary bismuthate nanoscale materials are discussed. The possible development direction of the ternary bismuthate nanoscale materials for the synthesis and application is also analyzed. RESULTS: The ternary bismuthate nanoscale materials including zinc bismuthate, copper bismuthate, barium bismuthate, silver bismuthate, sodium bismuthate, lanthanum bismuthate nanoscale materials can be synthesized by hydrothermal route, sol-gel route, solvothermal decomposition route and ionexchange method. The ternary bismuthate nanoscale materials exhibit great application promising in the fields of photocatalysts, sensors and batteries. CONCLUSION: Large-scale synthesis of ternary bismuthate nanoscale materials at low cost, doping and combination using different nanoscale materials are important research directions for future research.

The microRNA miR-3174 Suppresses the Expression of ADAM15 and Inhibits the Proliferation of Patient-Derived Bladder Cancer Cells.

BACKGROUND: Bladder cancer is a major urinary system cancer, and its mechanism of action regarding its progression is unclear. The goal of this study was to examine the expression of ADAM panel in the clinical specimens of bladder cancer and to investigate the role of miR-3174/ADAM15 (a disintegrin and metalloprotease 15) axis in the regulation of bladder cancer cell proliferation. METHODS: The expression of an ADAM gene panel (including ADAM8, 9, 10, 11, 12, 15, 17, 19, 22, 23, 28, and 33), including 30 pairs of bladder tumor and non-tumor specimens, was examined by Ion AmpliSeq Targeted Sequencing. A microRNA (miRNA) that could potentially target the ADAM with the highest expression level in the tumor tissue was identified using the online tool miRDB. Next, the interaction between the miRNA and ADAM15 was identified by Western blot. Finally, the proliferation of bladder cancer cells was examined using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) experiments (cell proliferation examining) and subcutaneous tumor models by using nude mice. RESULTS: The expression of ADAM15 in tumor tissue was found statistically significant when compared to its expression in non-tumor tissue. Additionally, ADAM15's expression in tumor tissue was found the highest of all other tested ADAMs. Next, by using the online tool miRDB, a microRNA termed miR-3174 was identified that targets ADAM15 and inhibits its expression by binding to its 3'-untranslated region. Finally, we found that overexpression of miR-3174 in bladder cancer cells inhibited the proliferation of cells due to the inhibition of ADAM15. CONCLUSION: In the present work, the data highlight that miR-3174 inhibits the proliferation of bladder cancer cells by targeting ADAM15.