ABSTRACT
OBJECTIVE: To explore the clinical efficacy of platelet-rich plasma (PRP) combined with arthroscopic meniscal plasty on meniscus injury of the knee joint in the elderly. METHODS: Fifty-six elderly patients with meniscus injuries were evaluated, including 28 patients who underwent arthroscopic meniscal repair and 28 patients who underwent arthroscopic meniscus repair combined with PRP injection. Primary outcomes included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lysholm score, Lequesne index, Range of motion (ROM), and secondary outcomes included bone gla-protein (BGP), insulin-like growth factor-1 (IGF-1), and matrix metalloproteinase-1 (MMP-1). The primary and secondary measurement outcomes were assessed for each patient before and after the 12 weeks of treatment. RESULTS: The VAS, WOMAC, Lysholm, Lequesne, and ROM were more improved in the PRP group compared to the control group (all P < 0.05). BGP, IGF-1, and MMP-1 were more reduced in the PRP group compared to the control group (all P < 0.05). CONCLUSION: The treatments of PRP combined with arthroscopic meniscal plasty can significantly improve the pain, function, and physiologicindicators in elderly patients.
ABSTRACT
Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are effective methods for the treatment of end-stage osteoarthritis. Furthermore, rehabilitation training and psychological interventions play significant roles in the recovery of hip and knee joint function after THA and TKA. A total of 46 patients who received hip replacement and knee replacement are equally divided into two groups, with the control group being prescribed routine rehabilitation intervention and the observation group prescribed an early rehabilitation pathway with Morita therapy intervention. According to the results, the observation group displayed a significantly decreased incidence of deep venous thrombosis, while simultaneously reducing the recovery time of lower limb function (P < 0.05), including straight leg raising time, walking time, and vertical knee flexion time. In addition, the treatment program demonstrates a significant ability to improve the joint function score, pain score, quality of life score, and range of motion score (P < 0.05). Moreover, serum D-dimer, fibrin degradation products (FDP), and femoral vein blood flow peak also are significantly reduced (P < 0.05). Therefore, we have determined that an early rehabilitation pathway combined with Morita therapy can effectively reduce stress pain, improve the recovery process of joint motor function, and reduce the incidence of thrombosis. However, an increased sample size would facilitate the confirmation of the safety and efficacy of the program. In addition, the overall financial expenditure and feasibility of the treatment need to be considered.
