Ligand-free high loading capacity ursolic acid self-carried nanovesicles enable hepatocyte targeting via absorbing apolipoproteins.

Ursolic acid (UA), a natural pentacyclic terpenoid carboxylic acid that can exert a potent hepatoprotective activity, has been developed into various types of nanoparticles to improve its pharmacological effects, however, the phagocytosis of nanoparticles by Kupffer cells greatly limits its efficacy. Herein, UA/Tween 80 nanovesicles (V-UA) were constructed and despite its simple composition, it fulfills multiple functions simultaneously: UA served as not only an active ingredient in the nanovesicle drug delivery system, but also acts as part of the carrier to stabilize UA/Tween 80 nanostructure; with a molar ratio of UA to Tween 80 up to 2:1, the formulation possesses a significant advantage of higher drug loading capacity; relative to liposomal UA (Lipo-UA), a conditional cellular uptake and higher accumulation of V-UA in hepatocytes provide insights into the hepatocytes targeting mechanisms of this nanovesicles. Favorable hepatocyte targeting ability also facilitates the treatment of liver diseases, which was well validated in three liver disease models.

Will the Policy Instruments Mix Promote the Facility Input of Care Institutions for Older People in China?

Promoting the facility input of care institutions for older people is the key to the development of the care for older people. With a steady increase in the proportion of older people in China, institutional care services are considered as an important tool for older people. Policies such as government bed subsidies and tax incentives are accelerating the development of institutional care services. However, when the care for older people related policy instrument mixes lacks overall comprehensiveness, consistency and balance, the policy instrument mixes may become a "policy mess", in turn, affecting the development of care institutions for older people. Studies focusing on the combined effects of different characteristics of a policy instrument mix are scarce. To understand how to better use the policy mix to facilitate the care for older people, it is necessary to analyze the characteristics of care policies for older people and its role in the construction of care institutions for older people. Therefore, this study analyzes the impacts of comprehensiveness, consistency, and balance of policy instruments on the facility input of care institutions for older people. An empirical analysis of related policies from 2011 to 2019 in China shows that a synergetic effect exists between the policy instrument mix and the facility input of care institutions for older people. This study points that the comprehensiveness and consistency of the policy instrument mix positively affect the facility input of care institutions for older people, while the impact of balance is not significant. It not only provides feasible policy suggestions for China's policy-making departments to optimize the care for older people related policies, but also helps care institutions for older people further understand the characteristics of policy portfolios and realize sustainable development.