ABSTRACT
Drug production consumes a large amount of raw materials and is recognized as a "high-pollution, high-energy-consumption" industry. In consideration of the small amount of emission inventory research in the pharmaceutical industry, firstly, based on the actual monitoring data and production information of typical antibiotic enterprises, the emission factors of various volatile organic compounds (VOCs) were determined using the field measurement method. Then, combined with the activity level information of antibiotics from A to G plant in the same park, the emission factor method was used to calculate and obtain the emissions of each plant, and an emission list was established. Uncertainty analysis of the list was carried out using the Monte Carlo method. Finally, the CALPUFF model was used to simulate the environmental impact range of the A-G plants in spring, summer, autumn, and winter. The results showed that the total VOCs emission factor in the production of antibiotic enterprises was 6655.61 g·t-1, and the crystallization process emission factor was the largest, at 3603.476 g·t-1. The A to G plants produce 6655.610, 7454.283, 998.342, 11980.098, 4492.537, 42462.792, and 18302.928 kg, respectively, of VOCs each year for the production of antibiotics, and the four substances with the largest emissions are butyl acetate, n-butanol, n-hexane, and acetone, respectively. Through the verification of the Monte Carlo model for plant A, it was found that the emissions of plant A basically presented as a lognormal distribution, and the uncertainty of 95% confidence interval was (-60.62%, 131.78%), which was within the acceptable range. Through CALPUFF simulation, the diffusion direction and range of VOCs were found to be different in each season, and an aggregation phenomenon occurs in summer.