ABSTRACT
Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors, especially programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have made a breakthrough in the treatment of NSCLC and changed the treatment pattern for NSCLC. Immunological checkpoint inhibitors targeting PD-1/PD-L1 are beneficial to patients, both in the first-line and second-line treatment of advanced NSCLC, in the adjuvant treatment of locally-advanced NSCLC, and in the neoadjuvant therapy of early NSCLC, which show an important role in the comprehensive treatment of NSCLC. This article reviews the clinical research progress of immunological checkpoint inhibitors targeting PD-1/PD-L1 in NSCLC. .
ABSTRACT
Objective To understand the emission rate and the attenuation rule of formaldehyde in the artificial woodiness boards for sell in China and to study the efficiency of formaldehyde-eliminator. Methods With the small Climate-Chamber and 4160 formaldehyde-analyzer, quantity of formaldehyde released from some kinds of woodiness boards was analyzed under the different condition of temperature, relative humidity and ventilation cycle. Results The emission rate of formaldehyde in most veneers was over 1.2 mg/(m2?h), in most of moderate density fibreboard, it was 0.7～1.0 mg/(m2?h) and in the veneer for medical application, it was 0.3～0.9 mg/(m2?h). Formaldehyde emission rates of all the three kinds of woodiness boards investigated in the present study showed a fall of 75% in a period of time after made, and met the National Standard of China. The formaldehyde eliminator could reduce the emission rate of formaldehyde remarkably, however the effect perhaps weakened in a short time. Conclusion The formaldehyde emission rates in all kinds of woodiness boards investigated in the present paper are different, they exceed the National Standard of China while the boards made immediately and will reduce after 10-15 days in a given condition. The formaldehyde eliminator used in the study shows a remarkable effect but lasts only a short time.
