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1.
ChemSusChem ; 5(2): 247-55, 2012 Feb 13.
Article in English | MEDLINE | ID: mdl-22275318

ABSTRACT

Over the years, organic synthesis has witnessed several improvements through the development of new chemical transformations or more efficient reagents for known processes. Likewise, technological advances, aiming at speeding up reactions and facilitating their work-up, have established themselves in academic as well as in industrial laboratories. In this Minireview, we highlight very recent developments in flow chemistry, focusing on organometallic reagents and catalysts. First, we describe reactions with homogeneous catalysts immobilized on different support materials using the concept of packed bed reactors. In the last chapter, we will discuss applications that utilize organometallic reagents.


Subject(s)
Metals/chemistry , Microtechnology/instrumentation , Catalysis , Dendrimers/chemistry , Indicators and Reagents/chemistry , Ionic Liquids/chemistry
2.
J Org Chem ; 75(2): 334-41, 2010 Jan 15.
Article in English | MEDLINE | ID: mdl-20000351

ABSTRACT

We have succeeded in the development of three approaches to the synthesis of aromatic compounds from 1,3-dicarbonyl compounds and alkynes. The first approach is a manganese-catalyzed [2+2+2] cycloaddition between 1,3-dicarbonyl compounds, which have no substituents at the active methylene moiety, and terminal alkynes. This reaction proceeds with high regioselectivity when aryl acetylenes are employed as the alkyne component. The second approach is a rhenium- or manganese-catalyzed formal [2+1+2+1] cycloaddition between beta-keto esters and two kinds of alkynes. In this reaction, the aromatic compounds are obtained by the following reaction sequence: (1) insertion of the first alkyne into a carbon-carbon single bond of a beta-keto ester, (2) formation of 2-pyranones via intramolecular cyclization with the elimination of ethanol, and (3) Diels-Alder reaction between the formed 2-pyranone and the second alkyne. This reaction provides multisubstituted aromatic compounds in a regioselective manner. The third approach is a rhenium-catalyzed formal [2+2+1+1] cycloaddition reaction from two 1,3-diketones and one alkyne. In this reaction, the aromatic skeleton is constructed from three carbons of the first 1,3-diketone, two carbons of the alkyne, and one carbon of the second 1,3-diketone.


Subject(s)
Alkynes/chemistry , Hydrocarbons, Aromatic/chemical synthesis , Ketones/chemistry , Manganese/chemistry , Rhenium/chemistry , Catalysis , Cyclization , Hydrocarbons, Aromatic/chemistry , Models, Molecular , Stereoisomerism
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