Effects of Tongxinluo Capsules on Serum CyPA and MMP-9 Levels in Patients with Coronary Heart Disease after PCI / 中国药房

OBJECTIVE:To investigate the effects of Tongxinluo capsules on the levels of serum cyclophilin A (CyPA) and matrix metalloproteinase-9 (MMP-9) in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).METHODS:A total of 115 CHD patients undergoing PCI were randomly divided into control group (59 cases) and observation group (56 cases).Control group was given conventional treatment.Observation group was additionally given Tongxinluo capsules 0.78 g,3 times a day,for consecutive 6 months,on the basis of control group.The levels of CyPA and MMP-9 as well as the occurrence of ADR were observed in 2 groups before and after treatment.RESULTS:Before treatment,there was no statistical significance in serum level of CyPA and MMP-9 between 2 groups (P＞0.05).The levels of CyPA in 2 groups 1 d and 1 month after surgery as well as the level of CyPA in control group 6 months after surgery were all significantly higher than before surgery,but the observation group was significantly lower than the control group 1 and 6 months,this index was decreased gradually as time,with statistical significance (P＜0.05).There was no statistical significance in the levels of CyPA between 2 groups 1 d after surgery or in observation group between 6 months after surgery and before surgery (P＞0.05).The levels of MMP-9 in 2 groups 1 d and 1 month after surgery were significantly higher than before surgery,and the observation group was significantly lower than the control group,this index was decreased gradually as time,with statistical significance (P＜0.05).There was no statistical significance in the levels of MMP-9 of 2 groups between 6 months after surgery and before surgery(P＞0.05).There was no statistical significance in the incidence of ADR between 2 groups (P＞0.05).CONCLUSIONS:Based on routine treatment,Tongxinluo capsules can significantly reduce the levels of CyPA and MMP-9 in CHD patients after PCI.

Modified posterior lumbar interbody fusion using a single cage with unilateral pedicle screws: a retrospective clinical study.

BACKGROUND: The traditional posterior lumbar interbody fusion (PLIF) technique usually involves implantation of two cages through a bilateral approach and bilateral laminectomy, which requires bilateral transpedicle screw fixation. The procedure itself has several negative impacts. Therefore, a modified PLIF procedure that includes insertion of a unilateral cage through the symptomatic side with supplementary unilateral pedicle screws has been conducted. MATERIALS AND METHODS: Thirty-one patients with unilateral radiculopathy who were diagnosed with spinal stenosis along with degenerative disc disease and a herniated intervertebral disc with lumbar instability underwent a unilateral PLIF using a single cage and unilateral pedicle screws. The postoperative clinical evaluation was based on the visual analogue scale (VAS) and the Oswestry Disability Index (ODI) for back pain and leg pain at multiple time points following the surgery. Radiological assessments were performed with lateral plain radiographs taken preoperation, immediately postoperation, 1, 2, 3 and 6 months postoperation and at the most recent follow-up. RESULTS: The patients all underwent a single-level fusion, and the mean duration for the surgeries was 94 min. The mean haemorrhage volume was 250 ml, and no blood transfusion was required for any of the cases. Twelve months postoperatively, all patients had achieved an Excellent or Good outcome (Excellent in 28 patients and Good in 3). The mean pain score was 6.8 prior to surgery and decreased to 2.3 at the 3-month postoperative examination. No significant complications or neurological deterioration occurred. None of the 31 patients appeared to have any fusion failure. No broken screw, screw loosening, significant cage migration or subsidence was observed in any of the cases. A mean increase in the intervertebral disc height of 3.14 mm from the preoperative measurement to the most recent follow-up examination was determined to be statistically significant (p = 0.05). CONCLUSIONS: Conducting PLIF using the diagonal insertion of a single cage with supplemental unilateral transpedicular screw instrumentation enables sufficient decompression and solid interbody fusion to be achieved with minimal invasion of the posterior spinal elements. This technique is a more clinically secure, straightforward and cost-effective way to perform PLIF.

Effect of interventional treatment on the expression of E-cadherin in bladder cancer / 实用放射学杂志

Objective To investigate the expressions of E-cadherin (E-cad)in arterial chemoembolization interventional therapied bladder carcinoma.Methods The expressions of E-cad in bladder tumor tissues of30 non-muscle-invasive bladder carcinoma treated with preoperative interventional chemotherapy and 20 invasive bladder carcinoma treated with surgical were measured by streptavi-din-peroxidase immunohisto chemical method.The changes of E-cad expression in bladder carcinoma before and after interventional treatment were analyzed.Results The averaged normal expressions rate of E-cad in non-muscle-invasive and muscle invasive bladder carcinoma was 70.0% (21/30),25.0% (5/20)respectively.The averaged normal expressions rate of E-cad after interventional treatment was improved to 90% (27/30),the differences were statistically significant (P <0.05 ).Conclusion The expressions of E-cad in bladder carcinoma had significant relations with pathological grade and clinical stage.The abnormal expressions of E-cad in the mucosal surface, may be associated with inflammation.Interventional treatment can significantly improve the expressions of E-cad of tumor tissue and delay the progress of bladder cancer.

The determination of parathyroid hormone in the chronic renal failure and its clinical significances / 医学研究生学报

The secondary hyperparathyroidism is one of the complications of chronic renal failure (CRF) and end stage renal failure (ESRD), and becomes more serious with the development of the primary disease. Parathyroid hormone (PTH) is considered as one of the biomarks of the development of renal failure. The purpose of this article will expound the physiological effects of the PTH, the causes and clinical significances of PTH rising in CRF and ESRD patients, the determination of PTH level, and the relationships between the increase of PTH and the polymorphism of CYP2D6, GSTT1,GSTM1.