ABSTRACT
Diagnostic significance of estimation of the tartratresistent acid phosphatase (bone TRAP--5b) activity was studied for prognosis of occurrence of metastases in bones (MB) in patients with a renal-cell cancer (RCC). The risk of the MB occurrence was determined in patients after surgical treatment. A skeleton affection rate in patients, to whom zolendronic acid was prescribed, was trustworthy bigger, than such while conduction of treatment. So, application of bisphosphonates is recommended, in particular--zolendronic acid in dosage 4 mg every month under control of the bone TRAP--5b activity with objective of prophylaxis of the MB occurrence in patients, suffering RCC. But, we recommend for the MB diagnosis the method of determination of this marker activity as additional one while examining patients together with standard methods, including osteoscintigraphy, computer tomography.
Subject(s)
Acid Phosphatase/genetics , Biomarkers, Tumor/genetics , Bone Density Conservation Agents/therapeutic use , Bone Neoplasms/prevention & control , Carcinoma, Renal Cell/prevention & control , Diphosphonates/therapeutic use , Imidazoles/therapeutic use , Isoenzymes/genetics , Kidney Neoplasms/surgery , Aged , Bone Neoplasms/genetics , Bone Neoplasms/secondary , Bone Neoplasms/surgery , Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/secondary , Carcinoma, Renal Cell/surgery , Drug Administration Schedule , Female , Gene Expression , Humans , Kidney Neoplasms/diagnostic imaging , Kidney Neoplasms/genetics , Kidney Neoplasms/pathology , Male , Middle Aged , Radiography , Tartrate-Resistant Acid Phosphatase , Tomography, Emission-Computed , Treatment Outcome , Zoledronic AcidABSTRACT
Disorders in the immune system manifesting in decreased weight and cellularity of lymphoid organs, decreased count of large granular lymphocytes, suppression of the immune response and metabolic activity of macrophages were observed in experimental animals 1-6 months after thyroidectomy. The intensity of these disorders depends on the period elapsed after the surgery. These disorders can result from not only changes in the levels of the pituitary-thyroid hormones, but also disturbances in the endocrine function of the thymus in thyroidectomized animals.