ABSTRACT
<b>Objective: </b>Doping is strongly prohibited in sports. Sports pharmacist was born in 2010 in Japan, and the anti-doping activity is expected. On the other hand, doping by arising from a lack of knowledge about prohibited substances in athletes, so-called “unwilling doping” is developing into a social issue. In this study, we investigated the percentage of prohibited substances in all drugs and prescriptions in a general hospital, to collect information to prevent an unwilling doping.<br><b>Methods: </b>We constructed system to extract the drugs corresponding to prohibited substances in the prescription order entry system in Otaru Municipal Hospital, and we analyzed 3,306 prescriptions of 10 to 59 years old patients, from July to September 2010.<br><b>Results: </b>Thirteen point five percent of our hospital drugs met definition of the prohibited substance. The number of prescriptions including prohibited substance(s) was 350 (10.6%), and its category was different from each age-group and clinical department.<br><b>Consideration: </b>Because prohibited substances are included in approximately 10% of prescriptions, athletes are exposed to danger of becoming an unwilling doping. Pharmacist should be well informed about prohibited substances to prevent athletes from unwilling doping. And they should provide information promptly and adequately for athletes.
ABSTRACT
The authors used polymer as a stable medium to protect Ag sol to get a stable signal for the unstable Ag sol. Poly-acrylic acid sodium was selected as the stable medium, which had a little effect on the SERS of thymine and made the SERS signal stable for thirty days. After aborative consideration and some trials, pyridine was picked as an internal standard for the quantitative detection of thymine. A linear correlation between the concentration of thymine and the ratio of thymine signal to pyridine signal intensity was obtained over a range of 2 x 10(-4)1 x 10(-3) mol x L(-1) with a correlation coefficient R2 of 0.975 4. The regression equation is: y = 3.143x + 0.348 7. The proposed method has the potential for quantitative analysis of the trace compounds having SERS effects.
